Targeting NRF2 With Isoeugenol: A Promising Small Molecule for Neurodegenerative, Metabolic, and Chronic Inflammatory Disorders

Oxidative Medicine and Cellular Longevity

2025 | journal-article

Chronopharmacokinetics of the antidepressant paroxetine: An in vitro and in vivo approach

Neuropharmacology

2025 | journal-article

Protective effects of irbesartan against neurodegeneration in APP/PS1 mice: Unraveling its triple anti-apoptotic, anti-inflammatory and anti-oxidant action

Biomedicine & Pharmacotherapy

2025 | journal-article

Novel mechanisms underlying rapid-acting antidepressants: ketamine-like compounds, neurosteroid GABAkines, and psychedelics

Drug Discovery Today

2025 | journal-article

A new population pharmacokinetic model for dosing optimization of zonisamide in patients with refractory epilepsy

European Journal of Pharmaceutical Sciences

2025 | journal-article

New low-dose curcumin derivative with therapeutic potential in Alzheimer’s disease: Results from an in vitro and in vivo study in mice

Neurobiology of Aging

2025 | journal-article

Pharmacokinetics of Non-Psychotropic Phytocannabinoids

Pharmaceutics

2025 | journal-article

Population pharmacokinetics of levetiracetam in patients diagnosed with refractory epilepsy: A real‐world study

Epilepsia

2025 | journal-article

Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

Biomedicine & Pharmacotherapy

2024 | journal-article

Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan

Biochemical Pharmacology

2024 | journal-article

Synthesis of a dehydrodieugenol B derivative as a lead compound for visceral leishmaniasis—mechanism of action and in vivo pharmacokinetic studies

Antimicrobial Agents and Chemotherapy

2024 | journal-article

Aging and cognitive resilience: Molecular mechanisms as new potential therapeutic targets

Drug Discovery Today

2024 | journal-article

Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for?

Ageing Research Reviews

2024 | journal-article

Development and validation of an HPLC-DAD method for the quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene in human plasma and mouse matrices

The Analyst

2024 | journal-article

Restoring the epigenome in Alzheimer's disease: advancing HDAC inhibitors as therapeutic agents

Drug Discovery Today

2024 | journal-article

Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences

Biochemical Pharmacology

2024 | journal-article

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Acta Pharmacologica Sinica

2024 | journal-article

Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression

European Journal of Pharmaceutics and Biopharmaceutics

2024 | journal-article

Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol

2023 | preprint

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

International Journal of Molecular Sciences

2023 | journal-article

Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics

Journal of Pharmaceutical Investigation

2023 | journal-article

Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability

International Journal of Pharmaceutics

2023 | journal-article

Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy

Pharmaceutics

2023 | journal-article

Air-liquid interface (ALI) impact on different respiratory cell cultures

European Journal of Pharmaceutics and Biopharmaceutics

2023 | journal-article

Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients

Antibiotics

2023 | journal-article

Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients

Biomedicines

2022 | journal-article

Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation

Frontiers in Pharmacology

2021 | journal-article

Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression

Pharmaceutics

2021 | journal-article

Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications.

Life sciences

2021 | journal-article

HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring.

Journal of pharmaceutical and biomedical analysis

2021 | journal-article

Is intranasal administration an opportunity for direct brain delivery of lacosamide?

European Journal of Pharmaceutical Sciences

2021 | journal-article

A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration

International Journal of Pharmaceutics

2021 | journal-article

Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients

Journal of Chromatography B

2021 | journal-article

Novel Routes to Accessing the Brain: Intranasal Administration

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

Understanding Brain Delivery

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

Cystic fibrosis: Physiopathology and the latest pharmacological treatments

Pharmacological Research

2020 | journal-article

Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders

Pharmacological Research

2020 | journal-article

Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy

Pharmaceutics

2020 | journal-article

QbD-driven development of intranasal lipid nanoparticles for depression treatment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration

Pharmaceutical Research

2020 | journal-article

Timing in drug absorption and disposition: the past, present and future of chronopharmacokinetics

British Journal of Pharmacology

2020 | journal-article

Nose-to-brain delivery of natural compounds for the treatment of central nervous system disorders

Current Pharmaceutical Design

2020 | journal-article

Anti-PD-1 immunotherapy in advanced metastatic melanoma: State of the art and future challenges

Life Sciences

2020 | journal-article

Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma

Journal of Pharmaceutical and Biomedical Analysis

2020 | journal-article

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges

Drug Discovery Today

2019 | journal-article

ABC transporters in Drug-resistant Epilepsy: Mechanisms of upregulation and therapeutic approaches

Pharmacological Research

2019 | journal-article

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review

Analytica Chimica Acta

2019 | journal-article

Nose-to-brain delivery of levetiracetam after intranasal administration to mice

International Journal of Pharmaceutics

2019 | journal-article

Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective

Current Drug Metabolism

2018 | journal-article

Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma

Bioanalysis

2018 | journal-article

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein

European Journal of Pharmaceutical Sciences

2018 | journal-article

Elucidation of the impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of catechol-O-methyltransferase inhibitors

Drug Metabolism and Disposition

2017 | journal-article

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays

European Journal of Pharmaceutical Sciences

2017 | journal-article

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates

International Journal of Pharmaceutics

2016 | journal-article

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples - A review

Analytica Chimica Acta

2013 | journal-article

A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites

Journal of Separation Science

2011 | journal-article