ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in HER2-positive breast cancer

2024 | other

Improved Chemical and Radiochemical Synthesis of Neuropeptide Y Y2 Receptor Antagonist N-Methyl-JNJ-31020028 and Preclinical Positron Emission Tomography Studies

Pharmaceuticals

2024 | journal-article

Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models

Journal of Neurochemistry

2023 | journal-article

Neurobehavioral sex-related differences in Nf1+/- mice: female show a “camouflaging”-type behavior

Biology of Sex Differences

2023 | journal-article

Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis

Small

2022 | journal-article

Mitochondrial and redox modifications in early stages of Huntington's disease

Redox Biology

2022 | journal-article

Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?

Multiple Sclerosis and Related Disorders

2022 | journal-article

Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments

Pharmaceutics

2022 | journal-article

Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease

Acta Neuropathologica Communications

2022 | journal-article

Sex-Dependent Social and Repetitive Behavior and Neurochemical Profile in Mouse Model of Autism Spectrum Disorder

Metabolites

2022 | journal-article

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.

Acta neuropathologica communications

2020 | journal-article

Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2020 | journal-article

Response of the cerebral vasculature to systemic carbon monoxide administration-Regional differences and sexual dimorphism.

The European journal of neuroscience

2020 | journal-article

A rat model of enhanced glycation mimics cardiac phenotypic components of human type 2 diabetes : A translational study using MRI.

Journal of diabetes and its complications

2020 | journal-article

Gd- and Eu-Loaded Iron Oxide@Silica Core–Shell Nanocomposites as Trimodal Contrast Agents for Magnetic Resonance Imaging and Optical Imaging

Inorganic Chemistry

2019 | journal-article

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study

Alzheimer's Research & Therapy

2019 | journal-article

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss

Human Molecular Genetics

2019 | journal-article

Dietary Glycotoxins Impair Hepatic Lipidemic Profile in Diet-Induced Obese Rats Causing Hepatic Oxidative Stress and Insulin Resistance

Oxidative Medicine and Cellular Longevity

2019 | journal-article

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Nanoscale

2019 | journal-article

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.

Molecular therapy : the journal of the American Society of Gene Therapy

2018 | journal-article

A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes.

Human molecular genetics

2018 | journal-article

High-fat diet induces a neurometabolic state characterized by changes in glutamate and N-acetylaspartate pools associated with early glucose intolerance: an in-vivo multimodal MRI study

Journal of Magnetic Resonance Imaging

2017 | journal-article

Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes.

Molecular autism

2017 | journal-article

Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance.

2017 | journal-article

Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior.

2017 | journal-article

Brain and behaviour phenotyping of a mouse model of neurofibromatosis type-1: an MRI/DTI study on social cognition.

2016 | journal-article

Cyclosporine A-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat.

2015 | journal-article

Minimização da nefrotoxicidade induzida pela Ciclosporina A através de protocolos de conversão para Sirolimus – Mecanismos e biomarcadores num modelo animal em rato

2015 | dissertation-thesis

Aging is Associated with Impaired Renal Function, INF-gamma Induced Inflammation and with Alterations in Iron Regulatory Proteins Gene Expression.

2014 | journal-article

Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment.

2014 | journal-article

Short and long term in vivo effects of Cyclosporine A and Sirolimus on genes and proteins involved in lipid metabolism in Wistar rats.

2014 | journal-article

Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model.

2014 | journal-article

Biomarkers of transition from Cyclosporine-induced renal dysfunction to nephrotoxicity

51th Congress of ERA-EDTA (European Renal Association - European Dialysis and Transplant Association)

2014 | conference-abstract

Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat: focus on serum, urine, gene, and protein renal expression biomarkers.

2014 | journal-article

Regulation of Liver and Kidney Erythropoietin Gene Expression in a Rat Model of Anemia Associated with Chronic Renal Failure

51st ERA-EDTA Congres

2014 | conference-poster

Regulation of liver and kidney erythropoietin gene expression in a rat model of anemia associated with chronic renal failure

51th Congress of ERA-EDTA(European Renal Association - European Dialysis and Transplant Association)

2014 | conference-abstract

Transcriptor factors responsible for EPO gene regulation, triggered by administration of rHuEPO high doses

51th Congress of ERA-EDTA (European Renal Association - European Dialysis and Transplant Association)

2014 | conference-poster

Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model.

2014 | journal-article

rhuEPO induced-hypertension leads to early renal damage

51th Congress of ERA-EDTA(European Renal Association - European Dialysis and Transplant Association)

2014 | conference-abstract

Different pathways and biomarkers of acute and chronic cyclosporineinduced nephrotoxicity in a rat model: focus on overexpression of mTOR and Mki67

Portuguese Journal of Nephrology & Hypertension

2013 | journal-article

Chemopreventive Efficacy of Atorvastatinn in a Rat Model of Bladder Cancer: Antioxidant, Anti-Proliferative and Anti-Inflammatory Properties

Acta urológica

2013 | journal-article

Effects of cyclosporine and sirolimus on insulin-stimulated glucose transport and glucose tolerance in a rat model.

2013 | journal-article

Serum and renal tissue markers of nephropathy in rats under immunosuppressive therapy: cyclosporine versus sirolimus.

2013 | journal-article

Aging is associated with a decreased in renal function and in iron availability, and with an increased in inflammation status

Encontro Renal 2013

2013 | conference-abstract

Cyclosporin-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat.

Encontro Renal 2013

2013 | conference-poster

Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women.

2013 | journal-article

Different pathways and biomarkers of acute and chronic cyclosporine-induced nephrotoxicity in a rat model–focus on overexpression of mTOR and Mki67 Authors Jo

Port J Nephrol Hypert

2013 | journal-article

Eficácia da atorvastatina na quimioprevenção da carcinogénese vesical num modelo experimental: Propriedades anti-oxidantes, anti-proliferativas e anti-inflamatórias

Acta Urológica

2013 | journal-article

Emergent biomarkers of residual cardiovascular risk in patients with low HDL-c and/or high triglycerides and average LDL-c concentrations: focus on HDL subpopulations, Oxidized LDL, adiponectin, and uric acid.

2013 | journal-article

Immunosupressive therapy optimization applied in transplantation: renal benefits of cyclosporine dose reduction and conversion to sirolimus in a rat model

25th Europen Congress of Pathology

2013 | conference-poster

Implication of low HDL-c levels in patients with average LDL-c levels – focus on oxidized LDL, large HDL subpopulation and adiponectin

4th PF2MUC Symposium - Personalized Medicine: Myth or Reality"; Postdoctoral Forum

2013 | conference-poster

Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

2013 | journal-article

Kidney mTOR and Mki67 overexpression as biomarkers of transition from cyclosporine-induced renal dysfunction to nephrotoxicity

5th Annual Meeting of IBILI

2013 | conference-poster

Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations.

2013 | journal-article

New markers of early cardiovascular risk in multiple sclerosis patients: oxidized-LDL correlates with clinical staging.

2013 | journal-article

Omega-3 fatty acids inhibit tumor growth in a rat model of bladder cancer.

2013 | journal-article

Software for the measurement of rodent brain structure volumes from MRI

5th Annual Meeting of IBILI

2013 | conference-poster

Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model.

2012 | journal-article

Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model.

2012 | journal-article

Cardiac antiapoptotic and proproliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat.

2012 | journal-article

Cardiac antiapoptotic and pro-proliferative effect of recombinant human erythropoietin in a moderate stage of chronic renal failure in the rat

J Pharm Bioallied Sci

2012 | journal-article

Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model

J Pharmacol Pharmacother

2012 | journal-article

Cardiorenal effects of cyclosporine and sirolimus-based immunosuppressive therapy protocols in an experimental rat model.

Conferência CEF 2012

2012 | conference-poster

Chemopreventive efficacy of Atorvastatin against nitrosamine-induced rat bladder cancer: antioxidant, anti-proliferative and anti-inflammatory properties.

2012 | journal-article

Conversion to sirolimus prevents cyclosporin-induced nephropathy in a rat model

20th Meeting of the EAU Section of Urological Research

2012 | conference-poster

Cross-talk between renal aging, inflammation, iron metabolism and erythropoiesis

IV Annual Meeting of IBILI

2012 | conference-poster

Cyclosporin-induced nephropathy can be avoided through early conversion to Sirolimus in a rat model.

IV annual Meeting of IBILI

2012 | conference-poster

Effects of rhEPO therapy in moderate versus severe renal failure induced by nephrectomy in an animal model

V Clinical Biochemistry Workshop

2012 | conference-poster

Erythropoietic response to rhEPO therapy is dependent on the stage of renal failure – an experimental study in nephrectomized rats

Encontro Renal 2012

2012 | conference-abstract

Immunosuppressive agents impair glucose and lipid metabolism in Wistar rats

V Clinical Biochemistry Workshop

2012 | conference-poster

Increased cardiovascular risk in men and postmenopause woman – evidences from non-traditional markers

IV Annual meeting of IBILI

2012 | conference-poster

Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model

Marine Drugs

2012 | journal-article

New biochemical clinical markers of dyslipidaemia and cardiometabolic risk in type 2 diabetes patients – focus on paraoxonase activity and HDL-c subpopulations

V Workshop Bioquímica Clínica

2012 | conference-poster

PON1 ACTIVITY IN HEMODIALYSIS PATIENTS: GENETIC AND NON-GENETIC FACTORS

49th Congress of the European-Renal-Association/European-Dialysis-and-Transplant-Association (ERA-EDTA)

2012 | conference-abstract

PON1 activity in hemodialysis patients: genetic and non-genetic factors

49th ERA-EDTA Congress

2012 | conference-poster

Recombinant human erythropoietin treatment promotes cardiorenal cytoprotection in a rat model of chronic renal failure.

20th Meeting of the EAU Section of Urological Research

2012 | conference-poster

Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat model – focus on renal lesions, oxidative stress, inflammation, proliferation and angiogenesis

Encontro Renal 2012

2012 | conference-poster

The relationship between serum and kidney gene expression in rats treated with calcineurin and mTOR inhibitors: inflammation, proliferation, angiogenesis and oxidative stress markers.

V Clinical Biochemistry Workshop

2012 | conference-poster

Inhibition of bladder tumour growth by sirolimus in an experimental carcinogenesis model.

2011 | journal-article

Cardiorenal and metabolic side-effects of immunosuppressive agentes in the rat: cyclosporin versus Sirolimus.

Postdoctoral Forum, Faculty of Medicine, University of Coimbra

2011 | conference-poster

Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus.

2011 | journal-article

Early versus late cyclosporin to sirolimus conversion in an animal model: focus on cardiorenal benefits

25º Congresso da Sociedade Portuguesa de Nefrologia

2011 | conference-poster

Erythropoietic response to rhEPO therapy in moderate versus severe renal failure induced by nephrectomy in the rat.

3rd Annual Meeting of IBILI

2011 | conference-poster

Oxidized-LDL as an earlier marker of cardiovascular risk in multiple sclerosis patients – correlation with clinical staging

III Annual meeting of IBILI

2011 | conference-poster

Paraoxonase activity and HDL-c subpopulations as markers of dyslipidaemia and cardiometabolic risk in type 2 diabetes patients

III Annual meeting of IBILI

2011 | conference-poster

Serum and renal tissue markers of inflammation, proliferation, angiogenesis and oxidative stress in rats under immunosuppressive therapy: cyclosporin versus Sirolimus.

3rd Annual Meeting of IBILI

2011 | conference-poster

XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia

XII Congresso Português de Endocrinologia e 62ª Reunião Anual da SPEDM

2011 | conference-poster

A actividade da paraoxonase 1 como marcador de risco cardiovascular numa população dislipidémica

Bioanálise

2010 | journal-article

Antidyslipidaemics treatment attenuates paraoxonase activity reduction in type 2 diabetes mellitus patients

Heart, Vessels & Diabetes - The European Conference

2010 | conference-poster

Cardiorenal and metabolic side-effects of immunosuppressive agents in the rat: Cyclosporin versus Sirolimus

II Annual Meeting of IBILI

2010 | conference-poster

Efeitos cardio-renais da terapêutica imunossupressora num modelo animal

Bioanálise

2010 | journal-article

Efeitos não hematológicos da eritropoietina num modelo de insuficiência renal induzida por nefrectomia

VIII Congresso de Análise Clínicas e Saúde Pública

2010 | conference-poster

Effect of Recombinant Human Erythropoietin in a Rat Model of Moderate Chronic Renal Failure – Focus on Inflammation, Oxidative Stress and Function/Renoprotection

The Open Drug Discovery Journal

2010 | journal-article

Effect of antidislipidaemics on paraoxonase activity in patients with type 2 diabetes mellitus

2nd National Meeting on Medicinal Chemistry /2enqt – SPQ

2010 | conference-poster

Effect of omega-3 fatty acids as chemopreventive therapy for bladder cancer in a rat model

XVII Congresso Nacional De Bioquímica

2010 | conference-poster

Effect of recombinant human erythropoietin in a rat model of moderate chronic renal failure – focus on inflammation, oxidative stress and function/renoprotection

The Open Drug Discovery Journal

2010 | journal-article

Effect of recombinant human erythropoietin therapy on kidney and heart gene expression profile in a model of moderate chronic renal failure

XVII Congresso Nacional de Bioquímica

2010 | conference-poster

Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat).

2010 | journal-article

Hemorrheological and cardiovascular effect of erythropoietin in a rat model of chronic sports doping

Bol SPHM

2010 | journal-article

Immunosuppressive agents alter glucose metabolism, blood pressure and heart rate in rats

XI International Symposium on Insulin Receptors and Insulin Action

2010 | conference-poster

Inhibition of bladder tumour growth by chitooligosaccharides in an experimental carcinogenesis model.

XVII Congresso Nacional De Bioquímica

2010 | conference-poster

Low adiponectin levels and paraoxonase activity as markers of oxidative stress and nflammation in atherosclerosis – study in a portuguese population

Proc Eur Assoc Clin Pharmacol Ther

2010 | journal-article

Novas terapêuticas da diabetes tipo 2: estudos em modelos animais

Bioanálise

2010 | journal-article

Omega-3 fatty acids therapy for prevention of nitrosamine-induced bladder cancer in a rat model.

2nd National Meeting on Medicinal Chemistry /2enqt

2010 | conference-poster

Paraoxonase 1 activity as a new inflammatory marker of cardiometabolic risk in type 2 diabetes mellitus patients

XVII Congresso Nacional de Bioquímica

2010 | conference-poster

Paraoxonase 1 activity as a predictive cardiovascular risk marker in Type 2 Diabetes

Journées Internationales de Biologie

2010 | conference-poster

Pleiotropic effects of rhEPO in an animal model of moderate chronic kidney disease

Scientif Workshop "Innovative therapies for red cell and iron related disorders"

2010 | conference-poster

Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model.

2010 | journal-article

Rationale for dpp-4 inhibition by sitagliptin in the management of type 2 diabetes

2nd National Meeting on Medicinal Chemistry /2enqt – SPQ

2010 | conference-poster

Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure.

2010 | journal-article

Recombinant human erythropoietin treatment protects the cardio-renal áxis in a model of moderate chronic renal failure

Renal Failure

2010 | journal-article

Utilização de parâmetros quantitativos e semi-quantitativos para avaliação dos Ilhéus de Langerhans num modelo animal de Diabetes Mellitus tipo 2

XV Encontro da Sociedade Portuguesa de Patologia Animal

2010 | conference-abstract

Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping.

2009 | journal-article

Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis.

2009 | journal-article

Hypertension induced by immunosuppressive drugs: a comparative analysis between sirolimus and cyclosporine.

2009 | journal-article

Adiponectin circulating levels as an emerging biomarker of cardiovascular risk in the portuguese population - a preliminary study

EUROMEDLAB Innsbruck 2009

2009 | conference-abstract

Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis

Cancer Biol Ther

2009 | journal-article

Antitumoral Properties of a Cyclooxigenase-2 Inhibitor and Immunosuppression Agents on Rat Urinary Bladder Carcinogenesis

Congres de la Société Internationale de Urologie

2009 | conference-abstract

Characterization of a rat model of moderate chronic renal failure--focus on hematological, biochemical, and cardio-renal profiles.

2009 | journal-article

Effects of recombinant human erythropoietin therapy on moderate stages of cardio-renal anemia syndrome - an experimental model

Third Congress of the International BioIron Society and the 8th International Symposium on Microbial Iron Transport, Storage and Metabolism

2009 | conference-poster

Erythropoietin doping as cause of sudden death in athletes – an experimental study

XXI Congresso da IALM (International Academy of Legal Medicine)

2009 | conference-poster

Evidences for earlier rh-epo therapy recommendation in chronic kidney disease – anti-apoptotic, anti-inflammatory, antioxidant, pro-proliferative and pro-angiogenic effects in an animal model

1st Anual Meeting IBILI

2009 | conference-poster

Inhibition of bladder tumor growth by a cyclooxygenase-2 inhibitor and immunosuppression agents in an experimental study

9th Congress of the European Association for Clinical Pharmacology and Therapeutics

2009 | conference-abstract

Low adiponectin levels and paraoxonase activity as markers of oxidative stress and inflammation in atherosclerosis – study in a portuguese population

9th Congresso da EACPT (European Association for Clinical Pharmacology and Therapeutics)

2009 | conference-poster

Pathophysiological mechanisms underlying the cardiovascular side-effects of sirolimus versus cyclosporine

XVI Congresso Nacional de Bioquímica

2009 | conference-poster

Recombinant human erythropoietin doping in sports – cardiovascular effects in chronic and acute aerobic exercise in an animal model

9th Congress of the European Association for Clinical Pharmacology and Therapeutics

2009 | conference-abstract

Recombinant human erythropoietin dopping in an experimental model of chronic aerobic exercice trining

Third Congress of the International BioIron Society and the 8th International Symposium on Microbial Iron Transport, Storage and Metabolism

2009 | conference-poster

Recombinant human erythropoietin therapy has beneficial cardio-renal effects on moderate stages of chronic renal failure in the rat

CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS, 9th

2009 | conference-abstract

Recombinant human erythropoietin therapy has beneficial cardio-renal effects on moderate stages of chronic renal failure in the rat

CONGRESS OF THE EUROPEAN ASSOCIATION FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS, 9th

2009 | conference-paper

Cardiovascular effects of recombinant human erythropoietin treatment on a rat experimental animal model of sports doping

XVI Congresso Nacional de Bioquímica

2008 | conference-poster

Complicações cardiovasculares do doping continuado com eritropoietina recombinante humana

7º Congresso Nacional de Medicina Legal

2008 | conference-poster

Contribution of adiponectin to low-grade inflammatory state as expressed by circulating C-reactive protein in a Portuguese population: a preliminary study

XVI Congresso Nacional de Bioquímica

2008 | conference-poster

Doping com rhEPO e risco cardiometabólico – treino crónico versus sessão extenuante

7.º Congresso nacional de medicina legal

2008 | conference-poster

Effects of immunosupression on a bladder carcinogenesis model in rats

VII Congresso Luso Brasileiro de Transplantação

2008 | conference-poster

Effects of recombinant human erythropoietin therapy on haematological, biochemical, oxidative and inflammatory profiles in an experimental model of renal failure

XVI Congresso Nacional de Bioquímica

2008 | conference-poster

Effects of rh erythropoietin treatment in an experimental model of moderate renal failure – haematological, biochemical, oxidative and inflammatory profiles

XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica e VIII Reunião de Toxicologia

2008 | conference-poster

HDL-containing paraoxonase activity as a new putative cardiovascular risk marker in dyslipidaemic obese patients

3º Workshop de Bioquímica Clínica

2008 | conference-poster

Hypertension induced by immunosuppressive drugs – comparative analysis between sirolimus and cyclosporine

VII Congresso Luso Brasileiro de Transplantação

2008 | conference-poster

Impairment of antioxidant paraoxonase activity and HDL-c protection in dyslipidaemic/obese patients.

XVI Congresso Nacional de Bioquímica

2008 | conference-poster

ANÁLISE DA PRÁTICA TRANSFUSIONAL EM CIRURGIA ORTOPÉDICA

I Simpósio de Imunohemoterapia

2000 | conference-abstract