Algoritmi | User | Ana Cristina Bairrada Fortuna

Ana Cristina Bairrada Fortuna

Ana Cristina Bairrada Fortuna

At LASI

Member of the CIBIT R&D Unit

Academic Degree

Current Position

at

Personal Webpage

Personal Email

anacfortuna@gmail.com

Orcid

0000-0001-6981-6639

Researcher ID

FCT Public Key

Ciência ID

E510-8BF0-1756

Google Scholar

About Me



Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma

2023 | conference-paper

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

International Journal of Molecular Sciences

2023 | journal-article

Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics

Journal of Pharmaceutical Investigation

2023 | journal-article

Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?

Ageing Research Reviews

2023 | journal-article

Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability

International Journal of Pharmaceutics

2023 | journal-article

Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy

Pharmaceutics

2023 | journal-article

Air-liquid interface (ALI) impact on different respiratory cell cultures

European Journal of Pharmaceutics and Biopharmaceutics

2023 | journal-article

Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients

Antibiotics

2023 | journal-article

From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder

Biochemical Pharmacology

2022 | journal-article

Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma

Molecular Genetics and Genomics

2022 | journal-article

A Stepwise Framework for the Systematic Development of Lipid Nanoparticles

Biomolecules

2022 | journal-article

INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS

2022 | patent

Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug

PBP World Meeting 2022

2022 | conference-poster

SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES

2022 | patent

Therapeutic drug monitoring of clozapine on patients with refractory schizophrenia

ESCP 2021 Virtual Symposium- Clinical pharmacy

2021 | conference-poster

The impact of smoking habits and comedicated drugs on clozapine/norclozapine ratios

4º Encontro SPFCS

2021 | conference-poster

The essential oil from the fruits of Peucedanum oreoselinum (L.) Moench (Apiaceae) as a natural source of P-glycoprotein inhibitors

Journal of Herbal Medicine

2021 | journal-article

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review

Journal of Pharmaceutical Analysis

2021 | journal-article

Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach

Chemosensors

2021 | journal-article

Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies

RDD 2021

2021 | conference-poster

In vitro release methodologies for nasal powder testing

PBP World Meeting

2021 | conference-poster

HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring

Journal of Pharmaceutical and Biomedical Analysis

2021 | journal-article

Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications

Life Sciences

2021 | journal-article

Quantificação de fármacos antiepiléticos em saliva humana como uma nova ferramenta de monitorização da terapêutica

 33º Encontro Nacional de Epileptologia

2021 | conference-poster

Is intranasal administration an opportunity for direct brain delivery of lacosamide?

European Journal of Pharmaceutical Sciences

2021 | journal-article

A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration

International Journal of Pharmaceutics

2021 | journal-article

Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients

Journal of Chromatography B

2021 | journal-article

Benchmarking of particle engineering technologies for nasal powder manufacture

DDL 2020

2020 | conference-poster

Cystic fibrosis: Physiopathology and the latest pharmacological treatments

Pharmacological Research

2020 | journal-article

Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders

Pharmacological Research

2020 | journal-article

Salting-out assisted liquid–liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices

Journal of Separation Science

2020 | journal-article

Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy

Pharmaceutics

2020 | journal-article

Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

British Journal of Pharmacology

2020 | journal-article

Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration

Pharmaceutical Research

2020 | journal-article

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

Current Pharmaceutical Design

2020 | journal-article

Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review

British Journal of Clinical Pharmacology

2020 | journal-article

Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.

Drug Repurposing in Cancer Therapy: Approaches and Applications

2020 | book-chapter

Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy

2020 | patent

Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development

Nanotherapy for Brain Tumor Drug Delivery

2020 | book-chapter

Establishing xenograft glioblastoma models for use in preclinical development

Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series

2020 | book-chapter

Novel Routes to Accessing the Brain: Intranasal Administration

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

QbD-driven development of intranasal lipid nanoparticles for depression treatment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Understanding brain delivery

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

How does the device determine nose-to-brain drug delivery to mice?

Drug Delivery to the Lungs (DDL 2019)

2019 | conference-poster

Nasal powder delivery: a step towards a biorelevant dissolution system

Drug Delivery to the Lungs (DDL2019)

2019 | conference-poster

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

Pharmaceuticals

2019 | journal-article

Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: the complexity of dose adjustments

48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)

2019 | conference-poster

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review

Analytica Chimica Acta

2019 | journal-article

Pharmacokinetic data model on assessing adherence to levetiracetam

48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)

2019 | conference-poster

Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies

Journal of Chromatography B

2019 | journal-article

Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice

Biomedical Chromatography

2019 | journal-article

Direct oral anticoagulants (DOACs) adjustment in patients with cardiac implantable devices and non-valvular atrial fibrillation, foccusing on renal adjustment: a single-centre retrospective study

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Nose-to-brain delivery of levetiracetam: preclinical evidence

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Therapeutic drug monitoring of levetiracetam: Pharmacokinetic characterization and compliance assessment of epileptic patients

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Nose-to-brain delivery of levetiracetam after intranasal administration to mice

International Journal of Pharmaceutics

2019 | journal-article

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics and clinical outcomes: GnG-PK/PD-AD study

Experimental and Clinical Psychopharmacology

2019 | journal-article

Silymarin as a Flavonoid-Type P-Glycoprotein Inhibitor with impact on the Pharmacokinetics of Carbamazepine, Oxcarbazepine and Phenytoin in Rats

Drug and Chemical Toxicology

2019 | journal-article

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

Pharmacological Research

2019 | journal-article

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges

Drug Discovery Today

2019 | journal-article

Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia

31º Encontro Nacional de Epileptologia

2019 | conference-poster

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

Journal of Pharmaceutical Analysis

2019 | journal-article

First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study

The Analyst

2019 | journal-article

Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff

Advances in Processing Technologies for Bio-based Nanosystems in Food

2019 | book-chapter

Real-World Clinical Characterization of Subjects With Depression Treated With Antidepressant Drugs Focused on (Non-)Genetic Factors, Pharmacokinetics, and Clinical Outcomes: GnG-PK/PD-AD Study

Experimental and Clinical Psychopharmacology

2019 | journal-article

Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles

International Journal of Pharmaceutics

2019 | journal-article

Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats

Drug and Chemical Toxicology

2019 | journal-article

Application of pharmacokinetic monitoring of amikacin in its pharmacological effects

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective

Current Drug Metabolism

2018 | journal-article

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.

Epilepsy Res.

2018 | journal-article

ADME-T and pharmacokinetic parameters of antitrypanosomal/antitumoral analogues of licarin A

41ª Reunião Anual da Sociedade Brasileira de Química

2018 | conference-poster

Desenvolvimento e validação de uma nova metodologia de quantificação simultânea da lacosamida, levetiracetam e zonisamida em plasma de doentes epilépticos

30º Encontro Nacional de Epileptologia

2018 | conference-poster

Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.

Bioanalysis

2018 | journal-article

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2018 | journal-article

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.

Food research international.

2018 | journal-article

Development and validation of an HPLC-FLD technique for colistin quantification and its plasma monitoring in hospitalized patients

Analytical Methods

2018 | journal-article

Evaluation of the pharmacokinetics of amikacin in neutropenic cancer patients: influence of cancer pathology and chemotherapy

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Genetic characterization of the CYP2C9, CYP2C19, CYP2D6 isoenzymes and P-glycoprotein in Portuguese depressive patients

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy

Epilepsy Research

2018 | journal-article

Levetiracetam therapy individualization: predictive performance of three pharmacokinetic models

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Microextraction Techniques in LC-MS Bioanalysis

Sample Preparation in LC-MS Bioanalysis

2018 | book-chapter

Monitoring lacosamide, levetiracetam, zonisamide in plasma of epileptic patients: personalizing the pharmacotherapy of levetiracetam

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors.

Drug metabolism and disposition: the biological fate of chemicals

2017 | journal-article

Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study.

Pharmaceutical research

2017 | journal-article

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

Neuropharmacology

2017 | journal-article

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.

Toxicology and applied pharmacology

2017 | journal-article

Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2017 | journal-article

Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy

Bioequivalence & Bioavailability International Journal.

2017 | journal-article

Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy

Bioequivalence & Bioavailability International Journal

2017 | journal-article

Flavonoid compounds as reversing agents of the P-glycoproteinmediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.

Food Research International.

2017 | magazine-article

Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats.

Food and Chemical Toxicology.

2017 | journal-article

Pharmacokinetics of Cymbopogon citratus Infusion in Rats after Single Oral Dose Administration.

SOJ Pharm Pharm Sci.

2017 | journal-article

P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review.

Natural product communications

2016 | journal-article

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.

International journal of pharmaceutics

2016 | journal-article

Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.

Biomedical chromatography : BMC

2016 | journal-article

Pharmacokinetics of opicapone, a novel catechol-O-methyltransferase inhibitor, in the Wistar rat

Parkinsonism & Related Disorders

2016 | journal-article

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.

International Journal of Pharmaceutics.

2016 | journal-article

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

Current drug metabolism

2016 | journal-article

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

Curr Drug Metab.

2016 | journal-article

Huperzine A from Huperzia serrata: a review os its sources, chemistry, pharmacology and toxicology.

Phytochemistry Reviews.

2016 | journal-article

P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review

Natural product Communications

2016 | journal-article

Amikacin plasma monitoring in treating Portuguese patients infected with Acinetobacter baumannii

44th ESCP Symposium on Clinical Pharmacy Lisbon, Portugal

2015 | conference-poster

2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development

Biomedical Chemistry

2015 | book-chapter

A new MEPS/HPLC assay to quantify venlafaxine and its main metabolite in human plasma

2015 | other

Development of a liquid chromatography assay for the determination of opicapone and BIA 9–1079 in rat matrices

Biomedical Chromatography

2015 | journal-article

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

International Journal of Pharmaceutics

2015 | journal-article

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

International Journal of Pharmaceutics

2015 | journal-article

Pharmacokinetics and Bioanalysis to Improve Drug Development: focus on pharmacokinetic studies

BIOMEDICAL CHEMISTRY - CURRENT TRENDS AND DEVELOPMENTS

2015 | book-chapter

Pharmacokinetics and bioanalysis to improve drug development

Biomedical Chemistry: Current Trends and Developments

2015 | book

The Pharmacology of Simvastatin: from the mechanism of action to new therapeuticapplications

SIMVASTATIN DELIVERY: CHALLENGES AND OPPORTUNITIES

2015 | book-chapter

The pharmacology of simvastatin: From the mechanism of action to new therapeutic applications

Simvastatin Delivery: Challenges and Opportunities

2015 | book

Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology

Phytochemistry Reviews

2014 | journal-article

Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting

European Journal of Pharmaceutical Sciences

2014 | journal-article

Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats

Journal of Pharmacy & Pharmaceutical Sciences

2014 | journal-article

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

Phytochemistry Reviews

2014 | journal-article

Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

Current Drug Safety

2014 | journal-article

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Chiral chromatographic resolution of antiepileptic drugs and their metabolites: A challenge from the optimization to the application

Biomedical Chromatography

2014 | journal-article

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

Phytochemistry Reviews

2014 | journal-article

Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats.

Journal of Pharmacy and Pharmaceutical Sciences

2014 | journal-article

Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting.

European Journal of Pharmaceutical Sciences

2014 | journal-article

Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules.

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V

2014 | journal-article

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2014 | journal-article

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine.

Journal of Chromatography B,

2014 | journal-article

Third- and Fourth-generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

Current Drug Safety

2014 | journal-article

An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.

The Analyst

2013 | journal-article

A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis

Bioanalysis

2013 | journal-article

First HPLC-UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2013 | journal-article

First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2013 | journal-article

Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples - A review

Analytica Chimica Acta

2013 | journal-article

Nose as a Route for Drug Delivery

Nasal Physiology and Pathophysiology of Nasal Disorders

2013 | book-chapter

Nose as a route for drug delivery

NASAL PHYSIOLOGY AND PATHOPHYSIOLOGY OF NASAL DISORDERS

2013 | book-chapter

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

Epilepsy Research

2013 | journal-article

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.

Epilepsy Research.

2013 | journal-article

A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain

Biomedical Chromatography

2012 | journal-article

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review

Analytical and Bioanalytical Chemistry

2012 | journal-article

Erratum: Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review (Analytical and Bioanalytical Chemistry DOI: 10.1007/s00216-011-5706-8)

Analytical and Bioanalytical Chemistry

2012 | journal-article

Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique

Epilepsia

2012 | journal-article

Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: Application to dibenz[b,f]azepine-5-carboxamide derivatives

Journal of Pharmaceutical Sciences

2012 | journal-article

Análise farmacométrica de derivados da carbamazepina: avaliação in vitro, in vivo e in silico das suas propriedades farmacológicas

Universidade de Coimbra

2011 | dissertation-thesis

A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites

Journal of Separation Science

2011 | journal-article

Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma

Biomedical Chromatography

2011 | journal-article

In Vitro?In Vivo Correlation (IVIVC): A Strategic Tool in Drug Development

Journal of Bioequivalence & Bioavailability

2011 | journal-article

BIOMEDICAL CHROMATOGRAPHY - Bioanalysis in drug discovery and development: focus on pharmacokinetic studies.

2010 | book-chapter

Binding of licarbazepine enantiomers to mouse and human plasma proteins

Biopharmaceutics and Drug Disposition

2010 | journal-article

Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies

Biomedical Chromatography

2010 | book

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

Analytical and Bioanalytical Chemistry

2010 | journal-article

Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites

Therapeutic Drug Monitoring

2010 | journal-article

Intranasal drug delivery: How, why and what for?

Journal of Pharmacy and Pharmaceutical Sciences

2009 | journal-article

Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma

Biomedical Chromatography

2007 | journal-article

The importance of permeability screening in drug discovery process: PAMPA, Caco-2 and rat everted gut assays

Current Topics in Pharmacology

2007 | journal-article

High-Performance Liquid Chromatography and its Impact in the Development of Chiral Drugs: a Review

Trends in Chromatography

| journal-article

Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma

2023 | conference-paper

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

International Journal of Molecular Sciences

2023 | journal-article

Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics

Journal of Pharmaceutical Investigation

2023 | journal-article

Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?

Ageing Research Reviews

2023 | journal-article

Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability

International Journal of Pharmaceutics

2023 | journal-article

Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy

Pharmaceutics

2023 | journal-article

Air-liquid interface (ALI) impact on different respiratory cell cultures

European Journal of Pharmaceutics and Biopharmaceutics

2023 | journal-article

Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients

Antibiotics

2023 | journal-article

From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder

Biochemical Pharmacology

2022 | journal-article

Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma

Molecular Genetics and Genomics

2022 | journal-article

A Stepwise Framework for the Systematic Development of Lipid Nanoparticles

Biomolecules

2022 | journal-article

INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS

2022 | patent

Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug

PBP World Meeting 2022

2022 | conference-poster

SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES

2022 | patent

Therapeutic drug monitoring of clozapine on patients with refractory schizophrenia

ESCP 2021 Virtual Symposium- Clinical pharmacy

2021 | conference-poster

The impact of smoking habits and comedicated drugs on clozapine/norclozapine ratios

4º Encontro SPFCS

2021 | conference-poster

The essential oil from the fruits of Peucedanum oreoselinum (L.) Moench (Apiaceae) as a natural source of P-glycoprotein inhibitors

Journal of Herbal Medicine

2021 | journal-article

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review

Journal of Pharmaceutical Analysis

2021 | journal-article

Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach

Chemosensors

2021 | journal-article

Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies

RDD 2021

2021 | conference-poster

In vitro release methodologies for nasal powder testing

PBP World Meeting

2021 | conference-poster

HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring

Journal of Pharmaceutical and Biomedical Analysis

2021 | journal-article

Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications

Life Sciences

2021 | journal-article

Quantificação de fármacos antiepiléticos em saliva humana como uma nova ferramenta de monitorização da terapêutica

 33º Encontro Nacional de Epileptologia

2021 | conference-poster

Is intranasal administration an opportunity for direct brain delivery of lacosamide?

European Journal of Pharmaceutical Sciences

2021 | journal-article

A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration

International Journal of Pharmaceutics

2021 | journal-article

Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients

Journal of Chromatography B

2021 | journal-article

Benchmarking of particle engineering technologies for nasal powder manufacture

DDL 2020

2020 | conference-poster

Cystic fibrosis: Physiopathology and the latest pharmacological treatments

Pharmacological Research

2020 | journal-article

Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders

Pharmacological Research

2020 | journal-article

Salting-out assisted liquid–liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices

Journal of Separation Science

2020 | journal-article

Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy

Pharmaceutics

2020 | journal-article

Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

British Journal of Pharmacology

2020 | journal-article

Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration

Pharmaceutical Research

2020 | journal-article

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

Current Pharmaceutical Design

2020 | journal-article

Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review

British Journal of Clinical Pharmacology

2020 | journal-article

Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.

Drug Repurposing in Cancer Therapy: Approaches and Applications

2020 | book-chapter

Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy

2020 | patent

Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development

Nanotherapy for Brain Tumor Drug Delivery

2020 | book-chapter

Establishing xenograft glioblastoma models for use in preclinical development

Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series

2020 | book-chapter

Novel Routes to Accessing the Brain: Intranasal Administration

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

QbD-driven development of intranasal lipid nanoparticles for depression treatment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Understanding brain delivery

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

How does the device determine nose-to-brain drug delivery to mice?

Drug Delivery to the Lungs (DDL 2019)

2019 | conference-poster

Nasal powder delivery: a step towards a biorelevant dissolution system

Drug Delivery to the Lungs (DDL2019)

2019 | conference-poster

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

Pharmaceuticals

2019 | journal-article

Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: the complexity of dose adjustments

48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)

2019 | conference-poster

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review

Analytica Chimica Acta

2019 | journal-article

Pharmacokinetic data model on assessing adherence to levetiracetam

48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)

2019 | conference-poster

Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies

Journal of Chromatography B

2019 | journal-article

Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice

Biomedical Chromatography

2019 | journal-article

Direct oral anticoagulants (DOACs) adjustment in patients with cardiac implantable devices and non-valvular atrial fibrillation, foccusing on renal adjustment: a single-centre retrospective study

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Nose-to-brain delivery of levetiracetam: preclinical evidence

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Therapeutic drug monitoring of levetiracetam: Pharmacokinetic characterization and compliance assessment of epileptic patients

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Nose-to-brain delivery of levetiracetam after intranasal administration to mice

International Journal of Pharmaceutics

2019 | journal-article

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics and clinical outcomes: GnG-PK/PD-AD study

Experimental and Clinical Psychopharmacology

2019 | journal-article

Silymarin as a Flavonoid-Type P-Glycoprotein Inhibitor with impact on the Pharmacokinetics of Carbamazepine, Oxcarbazepine and Phenytoin in Rats

Drug and Chemical Toxicology

2019 | journal-article

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

Pharmacological Research

2019 | journal-article

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges

Drug Discovery Today

2019 | journal-article

Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia

31º Encontro Nacional de Epileptologia

2019 | conference-poster

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

Journal of Pharmaceutical Analysis

2019 | journal-article

First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study

The Analyst

2019 | journal-article

Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff

Advances in Processing Technologies for Bio-based Nanosystems in Food

2019 | book-chapter

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