Algoritmi | User | Ana Cristina Bairrada Fortuna


Ana Cristina Bairrada Fortuna

Ana Cristina Bairrada Fortuna
Personal Email
anacfortuna@gmail.comOrcid
0000-0001-6981-6639Researcher ID
FCT Public Key
Ciência ID
E510-8BF0-1756Google Scholar
About Me
Ana Fortuna is graduated in Pharmaceutical Sciences since 2007 and obtained the PhD degree in Pharmaceutical Sciences, specialty of Pharmacology, in 2011 at the Faculty of Pharmacy of University of Coimbra (FFUC). In 2022, Ana Fortuna acquired the European Certified Pharmacologist (EuCP) from the Federation of European Pharmacological Societies (EPHAR) e European Association for Clinical Pharmacology and Therapeutics (EACPT). She is an Assistant Professor at FFUC since 2011 in the area of Pharmacology and Pharmaceutical Care and an integrated researcher at the Coimbra Institute for Biomedical Imaging and Translational Research of University of Coimbra (CIBIT). Ana Fortuna is member of the INTERNATIONAL NASAL RESEARCH GROUP as well as of the Associated Laboratory for Intelligent Systems and the Collaborative Laboratory for Promoting Translation and Discovery of Medicines (Bioscale). Ana Fortuna is currently the supervisor of 5 PhD students (1 in collaboration with the pharmaceutical industry, 2 with University of Barcelona), co-supervisor of 2 PhD students and supervisor of 4 Master students in Applied Pharmacology. She has already successfully supervised 4 PhD students, 25 master's students and 36 integrated master's degree students. Ana Fortuna is the Coordinator of the Applied Pharmacology Master since 2018, a member of the Pedagogical Council of FFUC since 2016, of the Equivalence Committee since 2019, of the Scientific Council of Institute for Nuclear Sciences Applied to Health (ICNAS) and of the Scientific Committee for coordinating the Doctorate in Nursing study cycle. Participated in 102 evaluation juries, namely 14 PhD juries (3 as main arguer), 56 Master's juries (35 as main arguer), 1 Undergraduate, 20 Doctoral Program Seminars and 9 public competition juries for hiring PhD Researchers and Research Fellows, wherein Ana Fortuna was the President of the Jury. With a SCOPUS H-INDEX of 31 and 3014 total CITATIONS (Google Scholar: H-index 34 and 4218 citations), Ana Fortuna published 105 articles in international journals (96 in the 1st or 2nd quartile); among them, she was the first/last author or the corresponding author of 47 manuscripts. She is also the author of 3 INTERATIONAL PATENTS, 1 Editorial, 14 book chapters, and 131 oral/poster communications at scientific national/international meetings. Ana Fortuna was the principal investigator of the projects CENTRO-01-0145-FEDER-030752 (funded by FCT, 2018-2022) and SustaINsafety (funded by INOVC+, 2022-2023), both with the objective of developing and validating intranasal administration systems for delivery of drugs for the brain. She additionally integrates 1 European Project and 3 national projects. She has also integrated other 7 national projects, and coordinated/integrated 7 projects financed by the pharmaceutical industry, and 3 strategic institutional projects as an Integrated Member of CIBIT. Throughout academic and scientific career, Ana Fortuna was awarded 14 SCIENTIFIC AWARDS, integrating, in 2022 and 2023, the World's Top 2% Scientist, according to a study by Stanford University (USA) and the Elsevier publishing group. Ana Fortuna has been invited to participate in relevant activities, involving the public and private sectors, highlighting the provision of services to public and private entities in conjunction with the University of Coimbra through the COORDINATION OF THE TECHNOLOGICAL PLATFORM OF THE UNIVERSITY OF COIMBRA – Unit of Pharmacokinetics and Bioanalysis. Ana Fortuna also leads the PkXplorer project, integrated at the University of Coimbra and in the Virtual Incubator at Instituto Pedro Nunes (IPN). The main research areas of investigation include: interaction between drugs and efflux transporters, in vitro/in vivo pharmacokinetics and pharmacodynamics of new drugs for depression, epilepsy and Alzheimer´s disease, as well as development/validation of bioanalytical techniques that are employed on drug pharmacokinetics monitoring throughout a personalized pharmacotherapy. These researches allowed Ana Fortuna to establish different collaborations, namely with pharmaceutical industries (BIAL Laboratories, Hovione, Aptar Pharma), Centro Hospitalar e Universitário de Coimbra (CHUC, EPE, Coimbra, Portugal) and other public national (University of Beira Interior, University of Porto, University of Aveiro and University of Algarve). At the international level, she collaborates with recognized researchers from Spain (University of Barcelona and University of Salamanca), Italy (University of Parma), Germany (Biberach University of Applied Sciences) and Brazil (Federal University of São Paulo).
Publications (258)
Chronopharmacokinetics of the antidepressant paroxetine: An in vitro and in vivo approach
Neuropharmacology
2025 | journal-article
Population pharmacokinetics of levetiracetam in patients diagnosed with refractory epilepsy: A real‐world study
Epilepsia
2025 | journal-article
A new population pharmacokinetic model for dosing optimization of zonisamide in patients with refractory epilepsy
European Journal of Pharmaceutical Sciences
2025 | journal-article
Pharmacokinetics of Non-Psychotropic Phytocannabinoids
Pharmaceutics
2025 | journal-article
Therapeutic effect of cyclosporine A-loading TPGS micelles on a mouse model of LPS-induced neuroinflammation
European Journal of Pharmaceutical Sciences
2025 | journal-article
Sex-dependent cortical morphometric and neurophysiological alterations in a genetic mouse model of tuberous sclerosis complex 2
3rd Annual Meeting of Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT)
2024 | conference-poster
Are we better together? Addressing a combined treatment of pitavastatin and temozolomide for brain cancer
European Journal of Pharmacology
2024 | journal-article
Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease
Biomedicine & Pharmacotherapy
2024 | journal-article
Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan
Biochemical Pharmacology
2024 | journal-article
Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for?
Ageing Research Reviews
2024 | journal-article
Drug–Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain
Pharmaceuticals
2024 | journal-article
Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences
Biochemical Pharmacology
2024 | journal-article
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
Acta Pharmacologica Sinica
2024 | journal-article
Possible relationship between tryptophan metabolism, serotonergic function and E/I neurotransmitters in Tuberous Sclerosis Complex 2
EMIM 2024
2024 | conference-poster
Enhancing glioblastoma therapy through lipid nanoparticle-mediated drug and gene co-delivery
XVth SPLC-CRS Conference on Controlled Drug Delivery: "New Horizons in Drug Delivery"
2024 | conference-poster
Intranasal irbesartan reverts cognitive decline and activates the PI3K/AKT pathway in an LPS-induced neuroinflammation mice model
International Immunopharmacology
2024 | journal-article
Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression
European Journal of Pharmaceutics and Biopharmaceutics
2024 | journal-article
Cannabinoid Modulation of Monoamine Levels in Mouse Brain: Unveiling Neurochemical Dynamics through an Innovative High-performance Liquid Chromatography-Fluorescence Detection Bioanalysis
Journal of Analysis and Testing
2024 | journal-article
Development and validation of an HPLC-DAD method for the quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene in human plasma and mouse matrices
The Analyst
2024 | journal-article
Intranasal Administration of Irbesartan as a New Strategy for Addressing Neurodegeneration in a Neuroinflammation Mice Model: Pharmacokinetic and Efficacy Evaluation
Congresso do Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra
2024 | conference-poster
The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for?
Ageing Research Reviews
2024 | journal-article
A new bioanalytical tool for neurotransmitter monitoring in central nervous system diseases
2nd Annual Meeting of CIBIT
2023 | conference-poster
Development of a Pharmacokinetic Model for Bayesian Individualization of Oral Levetiracetam in Refractory Epileptic Patients
2nd Annual Meeting of CIBIT
2023 | conference-poster
Negative correlation between cortical tryptophan metabolism and E/I balance in a genetic mouse model of autism spectrum disorders
2nd CIBIT Meeting
2023 | conference-poster
Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol
2023 | preprint
HPLC DAD technique for the quantification of cannabinoids in human plasma and mouse matrices
PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences
2023 | conference-poster
Unveiling the molecular mechanisms of pitavastatin induced glioblastoma death using proteomics
PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences
2023 | conference-poster
Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma
2023 | conference-paper
Decoding the molecular mechanisms of pitavastatin induced glioblastoma death through proteomics
ESN-ISN Neurochemistry School 2023
2023 | conference-poster
Gender Differences During Unpredictable Chronic Mild Stress (UCMS) And Paroxetine Intranasal Administration To Mice
36th ECNP Congress
2023 | conference-poster
Otimização da Entrega de Fármacos com Transportadores Lipídicos Nanoestruturados no Glioblastoma
X Congresso Iberoamericano em Ciências Farmacêuticas
2023 | conference-paper
Ultra High Performance Liquid Chromatography Technique to support Pharmacokinetic Monitoring of Losartan, Irbesartan and Valsartan
X Congresso Iberoamericano de Ciências Farmacêuticas
2023 | conference-poster
Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
International Journal of Molecular Sciences
2023 | journal-article
Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics
Journal of Pharmaceutical Investigation
2023 | journal-article
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?
Ageing Research Reviews
2023 | journal-article
Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability
International Journal of Pharmaceutics
2023 | journal-article
Achieving accurate measurements without breaking the bank: A highly sensitive technique for pitavastatin quantification in human plasma
XXVIII Encontro nacional da Sociedade Portuguesa de Química
2023 | conference-poster
Angiotensin Receptor Blockers as an Alternative Strategy for Addressing Neurodegeneration in a LPS Mice Model
Alzheimer’s Association International Congress
2023 | conference-poster
Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy
Pharmaceutics
2023 | journal-article
Air-liquid interface (ALI) impact on different respiratory cell cultures
European Journal of Pharmaceutics and Biopharmaceutics
2023 | journal-article
High Performance Liquid Chromatography Technique for the Quantification of Cannabigerol, Cannabidiol, Cannabinol and Cannabichromene in human plasma and mice matrix
International Scientific Congress - Clearing the smoke¿.: the importance of the endocannabinoid system in health and disease
2023 | conference-poster
Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients
Antibiotics
2023 | journal-article
Drug and Gene Delivery in Glioblastoma: Friends or Foes?, Delivery of RNA Therapeutics
Delivery of RNA Therapeutics, Final DARTER Meeting
2023 | conference-poster
Physiologically-Based Pharmacokinetic Modeling to Support the Determination of Drug Product Bioequivalence
Time-Proof Perspectives on Bioequivalence
2023 | book-chapter
From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder
Biochemical Pharmacology
2022 | journal-article
Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients
Biomedicines
2022 | journal-article
The quest for better treatments: a novel drug delivery approach to glioblastoma
IX Iberian Meeting on Colloids and Interfaces
2022 | conference-poster
Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel
International Journal of Pharmaceutics
2022 | journal-article
Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model
Toxicology in Vitro
2022 | journal-article
Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma
Molecular Genetics and Genomics
2022 | journal-article
Nose-to-brain delivery of perampanel using a non-toxic self-microemulsion drug delivery system.
52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia
2022 | conference-abstract
A Stepwise Framework for the Systematic Development of Lipid Nanoparticles
Biomolecules
2022 | journal-article
Optimizing nanostructured lipid carriers for the intra nasal administration of paroxetine and escitalopram in the treatment of depression
1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal
2022 | conference-poster
Nasal-PAMPA: a novel in vitro tool for prediction of intranasal drug permeability
Drug Delivery to the Lungs
2022 | conference-abstract
Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug
PBP World Meeting 2022
2022 | conference-poster
New HPLC technology for monitoring neurotransmitters in the brain: a pre-clinical approach for neurological disorders
ternational Multi-Brain Barcelona Congress - Healthy, Pathological and Artificial Brain
2022 | conference-poster
PCT/IB2022/052060 - SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES
2022 | patent
PCT/IB2022/061847 - WO/2023/105415: INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS
2022 | patent
Renin-angiotensin system acting drugs: a possible role in Alzheimer’s disease
International Multi-Brain Barcelona Congress - Healthy, Pathological and Artificial Brain
2022 | conference-poster
Taking the most out of lipids: A systematic design of lipid-based nanoparticles
1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal
2022 | conference-poster
Therapeutic drug monitoring of clozapine on patients with refractory schizophrenia
ESCP 2021 Virtual Symposium- Clinical pharmacy
2021 | conference-poster
DIRECT ORAL ANTICOAGULANTS (DOACS) USE IN PATIENTS WITH CARDIAC IMPLANTABLE DEVICES AND NON-VALVULAR ATRIAL FIBRILLATION: IMPACT OF OFF-LABEL DOSE USE IN SAFETY AND EFFICACY OUTCOMES
ESCP 2021 Symposium: Clinical pharmacy, working collaboratively in mental health care
2021 | conference-poster
The impact of smoking habits and comedicated drugs on clozapine/norclozapine ratios
4º Encontro SPFCS
2021 | conference-poster
The essential oil from the fruits of Peucedanum oreoselinum (L.) Moench (Apiaceae) as a natural source of P-glycoprotein inhibitors
Journal of Herbal Medicine
2021 | journal-article
Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review
Journal of Pharmaceutical Analysis
2021 | journal-article
Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach
Chemosensors
2021 | journal-article
Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies
RDD 2021
2021 | conference-poster
In vitro release methodologies for nasal powder testing
PBP World Meeting
2021 | conference-poster
HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring
Journal of Pharmaceutical and Biomedical Analysis
2021 | journal-article
Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications
Life Sciences
2021 | journal-article
Quantification of antiepileptic drugs in human saliva as a new tool of therapeutic monitoring.
33º Nacional Meeting of Epileptology
2021 | conference-poster
Quantificação de fármacos antiepiléticos em saliva humana como uma nova ferramenta de monitorização da terapêutica
33º Encontro Nacional de Epileptologia
2021 | conference-poster
Is intranasal administration an opportunity for direct brain delivery of lacosamide?
European Journal of Pharmaceutical Sciences
2021 | journal-article
Nose-to-brain delivery of perampanel: a promising therapeutic approach for epilepsy
51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of the Clinical Pharmacology and 20th Meeting of the Toxicology
2021 | conference-abstract
A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration
International Journal of Pharmaceutics
2021 | journal-article
Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients
Journal of Chromatography B
2021 | journal-article
Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: impact of off-label dose use in safety and efficacy outcomes
2021 | other
Benchmarking of particle engineering technologies for nasal powder manufacture
DDL 2020
2020 | conference-poster
Cystic fibrosis: Physiopathology and the latest pharmacological treatments
Pharmacological Research
2020 | journal-article
Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders
Pharmacological Research
2020 | journal-article
Salting-out assisted liquid–liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices
Journal of Separation Science
2020 | journal-article
Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy
Pharmaceutics
2020 | journal-article
Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment
European Journal of Pharmaceutics and Biopharmaceutics
2020 | journal-article
Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics
British Journal of Pharmacology
2020 | journal-article
Designing Lipid Nanoparticles for Intranasal Delivery of Antidepressants.
Journal of Aerosol Medicine and Pulmonary Drug Delivery
2020 | conference-abstract
Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
Pharmaceutical Research
2020 | journal-article
Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders
Current Pharmaceutical Design
2020 | journal-article
Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma
Journal of Pharmaceutical and Biomedical Analysis
2020 | journal-article
Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review
British Journal of Clinical Pharmacology
2020 | journal-article
Avaliação da adesão terapêutica em doentes com epilepsia medicados com levetiracetam recorrendo à monitorização farmacocinética
2020 | other
Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia
2020 | other
Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.
Drug Repurposing in Cancer Therapy: Approaches and Applications
2020 | book-chapter
Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development
Nanotherapy for Brain Tumor Drug Delivery
2020 | book-chapter
Establishing xenograft glioblastoma models for use in preclinical development
Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series
2020 | book-chapter
Nanotechnological approaches in cancer
Drug Repurposing in Cancer Therapy
2020 | book-chapter
Novel Routes to Accessing the Brain: Intranasal Administration
Nanoparticles for Brain Drug Delivery
2020 | book-chapter
PCT/IB2020/061452 - WO/2021/111364A1 : Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy
2020 | patent
QbD-driven development of intranasal lipid nanoparticles for depression treatment
European Journal of Pharmaceutics and Biopharmaceutics
2020 | journal-article
Understanding brain delivery
Nanoparticles for Brain Drug Delivery
2020 | book-chapter
How does the device determine nose-to-brain drug delivery to mice?
Drug Delivery to the Lungs (DDL 2019)
2019 | conference-poster
Nasal powder delivery: a step towards a biorelevant dissolution system
Drug Delivery to the Lungs (DDL2019)
2019 | conference-poster
Application of in vitro nasal model for antidepressant drug permeation studies
1st Annual Meeting in Pharmaceutical Sciences
2019 | conference-poster
Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I
Pharmaceuticals
2019 | journal-article
Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: the complexity of dose adjustments
48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)
2019 | conference-poster
Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review
Analytica Chimica Acta
2019 | journal-article
Pharmacokinetic data model on assessing adherence to levetiracetam
48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)
2019 | conference-poster
Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies
Journal of Chromatography B
2019 | journal-article
Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice
Biomedical Chromatography
2019 | journal-article
Development and validation of the first HPLC method for quantification of perampanel and stiripentol in mouse matrices using an innovator salting-out assisted liquid-liquid extraction procedure optimized by a design of experiments approach
53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI 2019)
2019 | conference-poster
Direct Oral Anticoagulants adjustment in patients with cardiac implantable devices and non-valvular Atrial Fibrillation: A single-centre retrospective study
53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
2019 | conference-poster
Direct oral anticoagulants (DOACs) adjustment in patients with cardiac implantable devices and non-valvular atrial fibrillation, foccusing on renal adjustment: a single-centre retrospective study
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Nose-to-brain delivery of levetiracetam: preclinical evidence
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Therapeutic drug monitoring of levetiracetam: Pharmacokinetic characterization and compliance assessment of epileptic patients
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Nose-to-brain delivery of levetiracetam after intranasal administration to mice
International Journal of Pharmaceutics
2019 | journal-article
Posters
European Journal of Clinical Investigation
2019 | journal-article
Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics and clinical outcomes: GnG-PK/PD-AD study
Experimental and Clinical Psychopharmacology
2019 | journal-article
Silymarin as a Flavonoid-Type P-Glycoprotein Inhibitor with impact on the Pharmacokinetics of Carbamazepine, Oxcarbazepine and Phenytoin in Rats
Drug and Chemical Toxicology
2019 | journal-article
ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches
Pharmacological Research
2019 | journal-article
Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges
Drug Discovery Today
2019 | journal-article
Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia
31º Encontro Nacional de Epileptologia
2019 | conference-poster
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices
Journal of Pharmaceutical Analysis
2019 | journal-article
Development and validation of the first HPLC-DAD method for rufinamide quantification in mouse plasma and tissues with focus on future pharmacokinetic studies.
XLIX Reunião da Sociedade Portuguesa de Farmacologia
2019 | conference-abstract
First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study
The Analyst
2019 | journal-article
How does the device determine nose-to-brain drug delivery to mice?
Drug Delivery to the Lungs (DDL 2019)
2019 | conference-paper
Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff
Advances in Processing Technologies for Bio-based Nanosystems in Food
2019 | book-chapter
Real-World Clinical Characterization of Subjects With Depression Treated With Antidepressant Drugs Focused on (Non-)Genetic Factors, Pharmacokinetics, and Clinical Outcomes: GnG-PK/PD-AD Study
Experimental and Clinical Psychopharmacology
2019 | journal-article
Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles
International Journal of Pharmaceutics
2019 | journal-article
Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats
Drug and Chemical Toxicology
2019 | journal-article
Application of pharmacokinetic monitoring of amikacin in its pharmacological effects
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective
Current Drug Metabolism
2018 | journal-article
In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.
Epilepsy Res.
2018 | journal-article
ADME-T and pharmacokinetic parameters of antitrypanosomal/antitumoral analogues of licarin A
41ª Reunião Anual da Sociedade Brasileira de Química
2018 | conference-poster
Desenvolvimento e validação de um método para quantificação simultânea de lacosamida, levetiracetam e zonisamida no plasma de doentes epiléticos
Encontro Nacional de Epileptologia
2018 | conference-poster
Desenvolvimento e validação de uma nova metodologia de quantificação simultânea da lacosamida, levetiracetam e zonisamida em plasma de doentes epilépticos
30º Encontro Nacional de Epileptologia
2018 | conference-poster
Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.
Bioanalysis
2018 | journal-article
In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2018 | journal-article
Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.
Food research international.
2018 | journal-article
Development and validation of an HPLC-FLD technique for colistin quantification and its plasma monitoring in hospitalized patients
Analytical Methods
2018 | journal-article
Evaluation of the pharmacokinetics of amikacin in neutropenic cancer patients: influence of cancer pathology and chemotherapy
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Genetic characterization of the CYP2C9, CYP2C19, CYP2D6 isoenzymes and P-glycoprotein in Portuguese depressive patients
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy
Epilepsy Research
2018 | journal-article
Levetiracetam therapy individualization: predictive performance of three pharmacokinetic models
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Microextraction Techniques in LC-MS Bioanalysis
Sample Preparation in LC-MS Bioanalysis
2018 | book-chapter
Monitoring lacosamide, levetiracetam, zonisamide in plasma of epileptic patients: personalizing the pharmacotherapy of levetiracetam
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-DAD: a tool to perform pharmacokinetic studies.
XIII Annual CICS-UBI Symposium 2018
2018 | conference-abstract
Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors.
Drug metabolism and disposition: the biological fate of chemicals
2017 | journal-article
Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study.
Pharmaceutical research
2017 | journal-article
Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2017 | journal-article
A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.
Neuropharmacology
2017 | journal-article
Potential of baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin and their dual combinations in reversing the P-glycoprotein-mediated antiepileptic drug resistance
32nd International Epilepsy Congress
2017 | conference-poster
Effects of the silymarin, a P-glycoprotein inhibitor, on the pharmacokinetics of oxcarbazepine and its active metabolite licarbazepine
II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications
2017 | conference-poster
Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.
Toxicology and applied pharmacology
2017 | journal-article
Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2017 | journal-article
Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2017 | journal-article
Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy
Bioequivalence & Bioavailability International Journal.
2017 | journal-article
Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy
Bioequivalence & Bioavailability International Journal
2017 | journal-article
Effect of kidney function on amikacin pharmacokinetics on hospitalized patients: a knowledge to improve therapy
2017 | other
Flavonoid compounds as reversing agents of the P-glycoproteinmediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.
Food Research International.
2017 | magazine-article
High risk of drug-induced phenoconversion and antidepressantdrug interactions at pharmacokinetic level in a naturalistic clinical setting
2017 | other
Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats.
Food and Chemical Toxicology.
2017 | journal-article
Pharmacokinetics of Cymbopogon citratus Infusion in Rats after Single Oral Dose Administration.
SOJ Pharm Pharm Sci.
2017 | journal-article
Flavonoids as potential reversing agents of the pharmacoresistance to antiepileptic drugs mediated by the P-glycoprotein
12th European Congress on Epileptology
2016 | conference-poster
Early results of next-gen cytogenetics implementation in Portugal
European Human Genetics Conference 2016
2016 | conference-paper
P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review.
Natural product communications
2016 | journal-article
A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.
International journal of pharmaceutics
2016 | journal-article
Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.
Biomedical chromatography : BMC
2016 | journal-article
Pharmacokinetics of opicapone, a novel catechol-O-methyltransferase inhibitor, in the Wistar rat
Parkinsonism & Related Disorders
2016 | journal-article
A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.
International Journal of Pharmaceutics.
2016 | journal-article
Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.
Current drug metabolism
2016 | journal-article
Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.
Curr Drug Metab.
2016 | journal-article
Huperzine A from Huperzia serrata: a review os its sources, chemistry, pharmacology and toxicology.
Phytochemistry Reviews.
2016 | journal-article
P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review
Natural product Communications
2016 | journal-article
Amikacin plasma monitoring in treating Portuguese patients infected with Acinetobacter baumannii
44th ESCP Symposium on Clinical Pharmacy Lisbon, Portugal
2015 | conference-poster
Phenytoin in pediatric patients: How important is the AEDs therapeutic drug monitoring?
44th ESCP Symposium on Clinical Pharmacy
2015 | conference-poster
2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development
Biomedical Chemistry
2015 | book-chapter
Development of a liquid chromatography assay for the determination of opicapone and BIA 9–1079 in rat matrices
Biomedical Chromatography
2015 | journal-article
Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice
International Journal of Pharmaceutics
2015 | journal-article
Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice
International Journal of Pharmaceutics
2015 | journal-article
Pharmacokinetics and Bioanalysis to Improve Drug Development: focus on pharmacokinetic studies
BIOMEDICAL CHEMISTRY - CURRENT TRENDS AND DEVELOPMENTS
2015 | book-chapter
Pharmacokinetics and bioanalysis to improve drug development
Biomedical Chemistry: Current Trends and Developments
2015 | book
The Pharmacology of Simvastatin: from the mechanism of action to new therapeuticapplications
SIMVASTATIN DELIVERY: CHALLENGES AND OPPORTUNITIES
2015 | book-chapter
The pharmacology of simvastatin: From the mechanism of action to new therapeutic applications
Simvastatin Delivery: Challenges and Opportunities
2015 | book
Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
Phytochemistry Reviews
2014 | journal-article
Development of a new PAMPA method for the prediction of blood-brain barrier permeation using an in-house brain lipid extract
17th International Symposium on Signal Transduction at the Blood-Brain and Blood-Retina Barriers
2014 | conference-poster
Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting
European Journal of Pharmaceutical Sciences
2014 | journal-article
Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats
Journal of Pharmacy & Pharmaceutical Sciences
2014 | journal-article
Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology
Phytochemistry Reviews
2014 | journal-article
Avaliação do potencial da via intranasal para a administração de fármacos antiepiléticos: aplicação à carbamazepina
26º Encontro Nacional de Epileptologia
2014 | conference-poster
Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety
2014 | journal-article
A new MEPS/HPLC assay to quantify venlafaxine and its main metabolite in human plasma
43rd European Symposium on Clinical Pharmacy
2014 | conference-poster
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Chiral chromatographic resolution of antiepileptic drugs and their metabolites: A challenge from the optimization to the application
Biomedical Chromatography
2014 | journal-article
Direct nose-to-brain delivery of carbamazepine after intranasal administration to mice.
9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
2014 | conference-paper
Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology
Phytochemistry Reviews
2014 | journal-article
Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats.
Journal of Pharmacy and Pharmaceutical Sciences
2014 | journal-article
Identification of P-glycoprotein inhibitors in Caco 2 cells: An in vitro screening methodology
9th World Meeting on Pharmaceutics
2014 | conference-paper
Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting.
European Journal of Pharmaceutical Sciences
2014 | journal-article
Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules.
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
2014 | journal-article
Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2014 | journal-article
Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine.
Journal of Chromatography B,
2014 | journal-article
Medication regimen complexity evaluation in a hypertensive Portuguese population
43rd European Symposium on Clinical Pharmacy
2014 | conference-poster
Third- and Fourth-generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety
2014 | journal-article
An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.
The Analyst
2013 | journal-article
A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis
Bioanalysis
2013 | journal-article
First HPLC-UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in human plasma
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2013 | journal-article
First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2013 | journal-article
Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples - A review
Analytica Chimica Acta
2013 | journal-article
Nose as a Route for Drug Delivery
Nasal Physiology and Pathophysiology of Nasal Disorders
2013 | book-chapter
Nose as a route for drug delivery
NASAL PHYSIOLOGY AND PATHOPHYSIOLOGY OF NASAL DISORDERS
2013 | book-chapter
Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models
Epilepsy Research
2013 | journal-article
Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.
Epilepsy Research.
2013 | journal-article
In vitro screening and in vivo preclinical models fo r pharmacokinetic evaluation of carbamazepine and derivatives
Conferência Centro de Estudos Farmacêuticos (CEF)
2012 | conference-poster
A new parallel artificial membrane permeability assay for estimation of intestinal absorption and protein binding in drug discovery programs
6th European Congress of Pharmacology, EPHAR 20 12
2012 | conference-poster
Development of an in vitro bidirectional transport model for prediction of human drug absorption and assessment of P-glycoprotein involvement in intestinal drug absorption.
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Fast HPLC-UV method for the simultaneous de termination of carbamazepine, lamotrigine, oxcarbazepine and phenytoin in mouse plasma, brain and liver tissues.
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Influence of plasma protein binding and efflux transport mediated by P-glycoprotein on the enantioselective biodisposition of eslicarbazepine and R-licarbazepine.
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Plasma and brain pharmacokinetic profiles of carbamazepine and nine derivatives after oral administration to mice: implications for selection of drug candidates.
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Quantification of ciprofloxacin in plasma and nasal mucosa matrices by high-performance liquid chromatography with fluorescence detection
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Avaliação farmacométrica in silico, in vitro e in viv o da carbamazepina e análogos estruturais.
24º Encontro Nacional de Epileptologia
2012 | conference-poster
A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain
Biomedical Chromatography
2012 | journal-article
Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review
Analytical and Bioanalytical Chemistry
2012 | journal-article
Erratum: Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review (Analytical and Bioanalytical Chemistry DOI: 10.1007/s00216-011-5706-8)
Analytical and Bioanalytical Chemistry
2012 | journal-article
Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique
Epilepsia
2012 | journal-article
Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: Application to dibenz[b,f]azepine-5-carboxamide derivatives
Journal of Pharmaceutical Sciences
2012 | journal-article
Análise farmacométrica de derivados da carbamazepina: avaliação in vitro, in vivo e in silico das suas propriedades farmacológicas
Universidade de Coimbra
2011 | dissertation-thesis
A rapid and robust HPLC-UV method for simultaneous quantification of three generations of anti-epileptic drugs in human plasma: carbamazepine, oxcarbazepine and eslicarbazepine acetate.
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
Assessment of the involvement of P-glycoprotein in intestinal drug absorption during drug discovery
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
Determination of norfloxacin, ciprofloxacin and lemofloxacin in hum an plasma by a simple and rapid liquid chromatographic method.
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
Development of an enantioselective high performance liquid chromatography analysis of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain.
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
Predicting human drug absorption with Parallel Artificial Membrane Permeability Assay.
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites
Journal of Separation Science
2011 | journal-article
Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma
Biomedical Chromatography
2011 | journal-article
In Vitro?In Vivo Correlation (IVIVC): A Strategic Tool in Drug Development
Journal of Bioequivalence & Bioavailability
2011 | journal-article
Novel HPLC-UV method to monitor plasma concentrations of six antiepileptic drugs and three of their main metabolites in patients with epilepsy.
Conferência Ibero-America na de Faculdades de Farmácia
2011 | conference-poster
A rapid and sensitive high-performance liquid chromatographic method to quantify carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.
WorldPharma2010 16th IUPHAR World Congress on Basis and Clinical Pharmacology
2010 | conference-poster
BIOMEDICAL CHROMATOGRAPHY - Bioanalysis in drug discovery and development: focus on pharmacokinetic studies.
2010 | book-chapter
Binding of licarbazepine enantiomers to mouse and human plasma proteins
Biopharmaceutics and Drug Disposition
2010 | journal-article
Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies
Biomedical Chromatography
2010 | book
Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma
Analytical and Bioanalytical Chemistry
2010 | journal-article
Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites
Therapeutic Drug Monitoring
2010 | journal-article
Lack of interference of Carbamazepine and its metabolites in the enantioselective therapeutic drug monitoring of eslicarbazepine acetate
WorldPharma2010 16th I UPHAR World Congress on Basis and Clinical Pharmacology
2010 | conference-poster
Morphological evaluation of rat liver tissue after the subcutaneous injection of 1,2-dimethylhydrazine
WorldPharma2010 16th IUPHAR World Congress on Basis and Clinical Pharmacology
2010 | conference-poster
Kidney drug exposure after multiple-dose administration of S- and R-licarbazepine to mice
38th American College of Clinical Pharmacology Annual Meeting. San Antonio (Texas)/Estados Unidos da América,
2009 | conference-poster
Plasma-brain distribution of licarbazapine enantiomers in mice on steady-state conditions
38th American College of Clinical Pharmacology Annual Meeting
2009 | conference-poster
Human plasma protein binding of S- and R-licarbazepine
XVIII CONGRESO de la Asociación Latinoamericana de Farmacología; XXX Reunión Anual Socie dad de Farmacología de Chile; XXIII Sociedad Chilena de Ciencias Fisiológicas; III Congreso Iberoamericano de Farmacología.
2009 | conference-poster
Intranasal drug delivery: How, why and what for?
Journal of Pharmacy and Pharmaceutical Sciences
2009 | journal-article
Metabolism and liver pharmacokinetics of S- and R-licarbazepine in mice at the steady-state.
38th American College of Clinical Pharmacology Annual Meeting
2009 | conference-poster
Plasma-brain distribution of licarbazepine enantiomers in mice on steady-state conditions.
38th American College of Clinical Pharmacology Annual Meeting
2009 | conference-poster
Plasma protein binding of licarbazepine enantiomers in human and mouse species.
1st International Epilepsy Colloquium
2008 | conference-poster
Binding of licarbazepine enantiomers to human serum albumin and alpha-1-a cid glycoprotein.
XVIII CONGRESO de la Asociación Latinoamericana de Farmacología; XXX Reunión Anual Socie dad de Farmacología de Chile; XXIII Sociedad Chilena de Ciencias Fisiológicas; III Congreso Iberoamericano de Farmacología.
2008 | conference-poster
Warfarin binding to human plasma proteins
2008 | other
Enantioselective HPLC-UV Assay for Eslicarbazepine Acetate (BIA 2-093) and its metabolites determination in mice plasma and tissues: application to pharmacokinetic studies.
Pharmaceutical Sciences World Congress (PSWC) 3rd World Congress of the Board of Pharmaceutical Sciences of FIP.
2007 | conference-poster
Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma
Biomedical Chromatography
2007 | journal-article
Lamotrigine in patients submitted to video-electroencephalographic monitoring : effect of co-medication in temporal and extratemporal epilepsy
1st International Epilepsy Colloquium.
2007 | conference-poster
The importance of permeability screening in drug discovery process: PAMPA, Caco-2 and rat everted gut assays
Current Topics in Pharmacology
2007 | journal-article
High-Performance Liquid Chromatography and its Impact in the Development of Chiral Drugs: a Review
Trends in Chromatography
| journal-article
Chronopharmacokinetics of the antidepressant paroxetine: An in vitro and in vivo approach
Neuropharmacology
2025 | journal-article
Population pharmacokinetics of levetiracetam in patients diagnosed with refractory epilepsy: A real‐world study
Epilepsia
2025 | journal-article
A new population pharmacokinetic model for dosing optimization of zonisamide in patients with refractory epilepsy
European Journal of Pharmaceutical Sciences
2025 | journal-article
Pharmacokinetics of Non-Psychotropic Phytocannabinoids
Pharmaceutics
2025 | journal-article
Therapeutic effect of cyclosporine A-loading TPGS micelles on a mouse model of LPS-induced neuroinflammation
European Journal of Pharmaceutical Sciences
2025 | journal-article
Sex-dependent cortical morphometric and neurophysiological alterations in a genetic mouse model of tuberous sclerosis complex 2
3rd Annual Meeting of Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT)
2024 | conference-poster
Are we better together? Addressing a combined treatment of pitavastatin and temozolomide for brain cancer
European Journal of Pharmacology
2024 | journal-article
Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease
Biomedicine & Pharmacotherapy
2024 | journal-article
Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan
Biochemical Pharmacology
2024 | journal-article
Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for?
Ageing Research Reviews
2024 | journal-article
Drug–Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain
Pharmaceuticals
2024 | journal-article
Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences
Biochemical Pharmacology
2024 | journal-article
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
Acta Pharmacologica Sinica
2024 | journal-article
Possible relationship between tryptophan metabolism, serotonergic function and E/I neurotransmitters in Tuberous Sclerosis Complex 2
EMIM 2024
2024 | conference-poster
Enhancing glioblastoma therapy through lipid nanoparticle-mediated drug and gene co-delivery
XVth SPLC-CRS Conference on Controlled Drug Delivery: "New Horizons in Drug Delivery"
2024 | conference-poster
Intranasal irbesartan reverts cognitive decline and activates the PI3K/AKT pathway in an LPS-induced neuroinflammation mice model
International Immunopharmacology
2024 | journal-article
Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression
European Journal of Pharmaceutics and Biopharmaceutics
2024 | journal-article
Cannabinoid Modulation of Monoamine Levels in Mouse Brain: Unveiling Neurochemical Dynamics through an Innovative High-performance Liquid Chromatography-Fluorescence Detection Bioanalysis
Journal of Analysis and Testing
2024 | journal-article
Development and validation of an HPLC-DAD method for the quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene in human plasma and mouse matrices
The Analyst
2024 | journal-article
Intranasal Administration of Irbesartan as a New Strategy for Addressing Neurodegeneration in a Neuroinflammation Mice Model: Pharmacokinetic and Efficacy Evaluation
Congresso do Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra
2024 | conference-poster
The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for?
Ageing Research Reviews
2024 | journal-article
A new bioanalytical tool for neurotransmitter monitoring in central nervous system diseases
2nd Annual Meeting of CIBIT
2023 | conference-poster
Development of a Pharmacokinetic Model for Bayesian Individualization of Oral Levetiracetam in Refractory Epileptic Patients
2nd Annual Meeting of CIBIT
2023 | conference-poster
Negative correlation between cortical tryptophan metabolism and E/I balance in a genetic mouse model of autism spectrum disorders
2nd CIBIT Meeting
2023 | conference-poster
Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol
2023 | preprint
HPLC DAD technique for the quantification of cannabinoids in human plasma and mouse matrices
PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences
2023 | conference-poster
Unveiling the molecular mechanisms of pitavastatin induced glioblastoma death using proteomics
PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences
2023 | conference-poster
Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma
2023 | conference-paper
Decoding the molecular mechanisms of pitavastatin induced glioblastoma death through proteomics
ESN-ISN Neurochemistry School 2023
2023 | conference-poster
Gender Differences During Unpredictable Chronic Mild Stress (UCMS) And Paroxetine Intranasal Administration To Mice
36th ECNP Congress
2023 | conference-poster
Otimização da Entrega de Fármacos com Transportadores Lipídicos Nanoestruturados no Glioblastoma
X Congresso Iberoamericano em Ciências Farmacêuticas
2023 | conference-paper
Ultra High Performance Liquid Chromatography Technique to support Pharmacokinetic Monitoring of Losartan, Irbesartan and Valsartan
X Congresso Iberoamericano de Ciências Farmacêuticas
2023 | conference-poster
Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
International Journal of Molecular Sciences
2023 | journal-article
Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics
Journal of Pharmaceutical Investigation
2023 | journal-article
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?
Ageing Research Reviews
2023 | journal-article
Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability
International Journal of Pharmaceutics
2023 | journal-article
Achieving accurate measurements without breaking the bank: A highly sensitive technique for pitavastatin quantification in human plasma
XXVIII Encontro nacional da Sociedade Portuguesa de Química
2023 | conference-poster
Angiotensin Receptor Blockers as an Alternative Strategy for Addressing Neurodegeneration in a LPS Mice Model
Alzheimer’s Association International Congress
2023 | conference-poster
Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy
Pharmaceutics
2023 | journal-article
Air-liquid interface (ALI) impact on different respiratory cell cultures
European Journal of Pharmaceutics and Biopharmaceutics
2023 | journal-article
High Performance Liquid Chromatography Technique for the Quantification of Cannabigerol, Cannabidiol, Cannabinol and Cannabichromene in human plasma and mice matrix
International Scientific Congress - Clearing the smoke¿.: the importance of the endocannabinoid system in health and disease
2023 | conference-poster
Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients
Antibiotics
2023 | journal-article
Drug and Gene Delivery in Glioblastoma: Friends or Foes?, Delivery of RNA Therapeutics
Delivery of RNA Therapeutics, Final DARTER Meeting
2023 | conference-poster
Physiologically-Based Pharmacokinetic Modeling to Support the Determination of Drug Product Bioequivalence
Time-Proof Perspectives on Bioequivalence
2023 | book-chapter
From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder
Biochemical Pharmacology
2022 | journal-article
Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients
Biomedicines
2022 | journal-article
The quest for better treatments: a novel drug delivery approach to glioblastoma
IX Iberian Meeting on Colloids and Interfaces
2022 | conference-poster
Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel
International Journal of Pharmaceutics
2022 | journal-article
Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model
Toxicology in Vitro
2022 | journal-article
Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma
Molecular Genetics and Genomics
2022 | journal-article
Nose-to-brain delivery of perampanel using a non-toxic self-microemulsion drug delivery system.
52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia
2022 | conference-abstract
A Stepwise Framework for the Systematic Development of Lipid Nanoparticles
Biomolecules
2022 | journal-article
Optimizing nanostructured lipid carriers for the intra nasal administration of paroxetine and escitalopram in the treatment of depression
1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal
2022 | conference-poster
Nasal-PAMPA: a novel in vitro tool for prediction of intranasal drug permeability
Drug Delivery to the Lungs
2022 | conference-abstract
Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug
PBP World Meeting 2022
2022 | conference-poster
New HPLC technology for monitoring neurotransmitters in the brain: a pre-clinical approach for neurological disorders
ternational Multi-Brain Barcelona Congress - Healthy, Pathological and Artificial Brain
2022 | conference-poster
PCT/IB2022/052060 - SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES
2022 | patent
PCT/IB2022/061847 - WO/2023/105415: INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS
2022 | patent
Renin-angiotensin system acting drugs: a possible role in Alzheimer’s disease
International Multi-Brain Barcelona Congress - Healthy, Pathological and Artificial Brain
2022 | conference-poster
Taking the most out of lipids: A systematic design of lipid-based nanoparticles
1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal
2022 | conference-poster
Therapeutic drug monitoring of clozapine on patients with refractory schizophrenia
ESCP 2021 Virtual Symposium- Clinical pharmacy
2021 | conference-poster
DIRECT ORAL ANTICOAGULANTS (DOACS) USE IN PATIENTS WITH CARDIAC IMPLANTABLE DEVICES AND NON-VALVULAR ATRIAL FIBRILLATION: IMPACT OF OFF-LABEL DOSE USE IN SAFETY AND EFFICACY OUTCOMES
ESCP 2021 Symposium: Clinical pharmacy, working collaboratively in mental health care
2021 | conference-poster
The impact of smoking habits and comedicated drugs on clozapine/norclozapine ratios
4º Encontro SPFCS
2021 | conference-poster
The essential oil from the fruits of Peucedanum oreoselinum (L.) Moench (Apiaceae) as a natural source of P-glycoprotein inhibitors
Journal of Herbal Medicine
2021 | journal-article
Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review
Journal of Pharmaceutical Analysis
2021 | journal-article
Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach
Chemosensors
2021 | journal-article
Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies
RDD 2021
2021 | conference-poster
In vitro release methodologies for nasal powder testing
PBP World Meeting
2021 | conference-poster
HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring
Journal of Pharmaceutical and Biomedical Analysis
2021 | journal-article
Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications
Life Sciences
2021 | journal-article
Quantification of antiepileptic drugs in human saliva as a new tool of therapeutic monitoring.
33º Nacional Meeting of Epileptology
2021 | conference-poster
Quantificação de fármacos antiepiléticos em saliva humana como uma nova ferramenta de monitorização da terapêutica
33º Encontro Nacional de Epileptologia
2021 | conference-poster
Is intranasal administration an opportunity for direct brain delivery of lacosamide?
European Journal of Pharmaceutical Sciences
2021 | journal-article
Nose-to-brain delivery of perampanel: a promising therapeutic approach for epilepsy
51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of the Clinical Pharmacology and 20th Meeting of the Toxicology
2021 | conference-abstract
A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration
International Journal of Pharmaceutics
2021 | journal-article
Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients
Journal of Chromatography B
2021 | journal-article
Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: impact of off-label dose use in safety and efficacy outcomes
2021 | other
Benchmarking of particle engineering technologies for nasal powder manufacture
DDL 2020
2020 | conference-poster
Cystic fibrosis: Physiopathology and the latest pharmacological treatments
Pharmacological Research
2020 | journal-article
Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders
Pharmacological Research
2020 | journal-article
Salting-out assisted liquid–liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices
Journal of Separation Science
2020 | journal-article
Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy
Pharmaceutics
2020 | journal-article
Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment
European Journal of Pharmaceutics and Biopharmaceutics
2020 | journal-article
Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics
British Journal of Pharmacology
2020 | journal-article
Designing Lipid Nanoparticles for Intranasal Delivery of Antidepressants.
Journal of Aerosol Medicine and Pulmonary Drug Delivery
2020 | conference-abstract
Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
Pharmaceutical Research
2020 | journal-article
Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders
Current Pharmaceutical Design
2020 | journal-article
Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma
Journal of Pharmaceutical and Biomedical Analysis
2020 | journal-article
Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review
British Journal of Clinical Pharmacology
2020 | journal-article
Avaliação da adesão terapêutica em doentes com epilepsia medicados com levetiracetam recorrendo à monitorização farmacocinética
2020 | other
Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia
2020 | other
Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.
Drug Repurposing in Cancer Therapy: Approaches and Applications
2020 | book-chapter
Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development
Nanotherapy for Brain Tumor Drug Delivery
2020 | book-chapter
Establishing xenograft glioblastoma models for use in preclinical development
Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series
2020 | book-chapter
Nanotechnological approaches in cancer
Drug Repurposing in Cancer Therapy
2020 | book-chapter
Novel Routes to Accessing the Brain: Intranasal Administration
Nanoparticles for Brain Drug Delivery
2020 | book-chapter
PCT/IB2020/061452 - WO/2021/111364A1 : Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy
2020 | patent
QbD-driven development of intranasal lipid nanoparticles for depression treatment
European Journal of Pharmaceutics and Biopharmaceutics
2020 | journal-article
Understanding brain delivery
Nanoparticles for Brain Drug Delivery
2020 | book-chapter
How does the device determine nose-to-brain drug delivery to mice?
Drug Delivery to the Lungs (DDL 2019)
2019 | conference-poster
Nasal powder delivery: a step towards a biorelevant dissolution system
Drug Delivery to the Lungs (DDL2019)
2019 | conference-poster
Application of in vitro nasal model for antidepressant drug permeation studies
1st Annual Meeting in Pharmaceutical Sciences
2019 | conference-poster
Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I
Pharmaceuticals
2019 | journal-article
Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: the complexity of dose adjustments
48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)
2019 | conference-poster
Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review
Analytica Chimica Acta
2019 | journal-article
Pharmacokinetic data model on assessing adherence to levetiracetam
48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)
2019 | conference-poster
Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies
Journal of Chromatography B
2019 | journal-article
Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice
Biomedical Chromatography
2019 | journal-article
Development and validation of the first HPLC method for quantification of perampanel and stiripentol in mouse matrices using an innovator salting-out assisted liquid-liquid extraction procedure optimized by a design of experiments approach
53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI 2019)
2019 | conference-poster
Direct Oral Anticoagulants adjustment in patients with cardiac implantable devices and non-valvular Atrial Fibrillation: A single-centre retrospective study
53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
2019 | conference-poster
Direct oral anticoagulants (DOACs) adjustment in patients with cardiac implantable devices and non-valvular atrial fibrillation, foccusing on renal adjustment: a single-centre retrospective study
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Nose-to-brain delivery of levetiracetam: preclinical evidence
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Therapeutic drug monitoring of levetiracetam: Pharmacokinetic characterization and compliance assessment of epileptic patients
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Nose-to-brain delivery of levetiracetam after intranasal administration to mice
International Journal of Pharmaceutics
2019 | journal-article
Posters
European Journal of Clinical Investigation
2019 | journal-article
Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics and clinical outcomes: GnG-PK/PD-AD study
Experimental and Clinical Psychopharmacology
2019 | journal-article
Silymarin as a Flavonoid-Type P-Glycoprotein Inhibitor with impact on the Pharmacokinetics of Carbamazepine, Oxcarbazepine and Phenytoin in Rats
Drug and Chemical Toxicology
2019 | journal-article
ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches
Pharmacological Research
2019 | journal-article
Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges
Drug Discovery Today
2019 | journal-article
Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia
31º Encontro Nacional de Epileptologia
2019 | conference-poster
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices
Journal of Pharmaceutical Analysis
2019 | journal-article
Development and validation of the first HPLC-DAD method for rufinamide quantification in mouse plasma and tissues with focus on future pharmacokinetic studies.
XLIX Reunião da Sociedade Portuguesa de Farmacologia
2019 | conference-abstract
First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study
The Analyst
2019 | journal-article
How does the device determine nose-to-brain drug delivery to mice?
Drug Delivery to the Lungs (DDL 2019)
2019 | conference-paper
Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff
Advances in Processing Technologies for Bio-based Nanosystems in Food
2019 | book-chapter
Real-World Clinical Characterization of Subjects With Depression Treated With Antidepressant Drugs Focused on (Non-)Genetic Factors, Pharmacokinetics, and Clinical Outcomes: GnG-PK/PD-AD Study
Experimental and Clinical Psychopharmacology
2019 | journal-article
Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles
International Journal of Pharmaceutics
2019 | journal-article
Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats
Drug and Chemical Toxicology
2019 | journal-article
Application of pharmacokinetic monitoring of amikacin in its pharmacological effects
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective
Current Drug Metabolism
2018 | journal-article
In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.
Epilepsy Res.
2018 | journal-article
ADME-T and pharmacokinetic parameters of antitrypanosomal/antitumoral analogues of licarin A
41ª Reunião Anual da Sociedade Brasileira de Química
2018 | conference-poster
Desenvolvimento e validação de um método para quantificação simultânea de lacosamida, levetiracetam e zonisamida no plasma de doentes epiléticos
Encontro Nacional de Epileptologia
2018 | conference-poster
Desenvolvimento e validação de uma nova metodologia de quantificação simultânea da lacosamida, levetiracetam e zonisamida em plasma de doentes epilépticos
30º Encontro Nacional de Epileptologia
2018 | conference-poster
Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.
Bioanalysis
2018 | journal-article
In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2018 | journal-article
Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.
Food research international.
2018 | journal-article
Development and validation of an HPLC-FLD technique for colistin quantification and its plasma monitoring in hospitalized patients
Analytical Methods
2018 | journal-article
Evaluation of the pharmacokinetics of amikacin in neutropenic cancer patients: influence of cancer pathology and chemotherapy
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Genetic characterization of the CYP2C9, CYP2C19, CYP2D6 isoenzymes and P-glycoprotein in Portuguese depressive patients
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy
Epilepsy Research
2018 | journal-article
Levetiracetam therapy individualization: predictive performance of three pharmacokinetic models
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Microextraction Techniques in LC-MS Bioanalysis
Sample Preparation in LC-MS Bioanalysis
2018 | book-chapter
Monitoring lacosamide, levetiracetam, zonisamide in plasma of epileptic patients: personalizing the pharmacotherapy of levetiracetam
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-DAD: a tool to perform pharmacokinetic studies.
XIII Annual CICS-UBI Symposium 2018
2018 | conference-abstract
Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors.
Drug metabolism and disposition: the biological fate of chemicals
2017 | journal-article
Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study.
Pharmaceutical research
2017 | journal-article
Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2017 | journal-article
A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.
Neuropharmacology
2017 | journal-article
Potential of baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin and their dual combinations in reversing the P-glycoprotein-mediated antiepileptic drug resistance
32nd International Epilepsy Congress
2017 | conference-poster
Effects of the silymarin, a P-glycoprotein inhibitor, on the pharmacokinetics of oxcarbazepine and its active metabolite licarbazepine
II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications
2017 | conference-poster
Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.
Toxicology and applied pharmacology
2017 | journal-article
Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2017 | journal-article
Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2017 | journal-article
Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy
Bioequivalence & Bioavailability International Journal.
2017 | journal-article
Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy
Bioequivalence & Bioavailability International Journal
2017 | journal-article
Effect of kidney function on amikacin pharmacokinetics on hospitalized patients: a knowledge to improve therapy
2017 | other
Flavonoid compounds as reversing agents of the P-glycoproteinmediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.
Food Research International.
2017 | magazine-article
High risk of drug-induced phenoconversion and antidepressantdrug interactions at pharmacokinetic level in a naturalistic clinical setting
2017 | other
Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats.
Food and Chemical Toxicology.
2017 | journal-article
Pharmacokinetics of Cymbopogon citratus Infusion in Rats after Single Oral Dose Administration.
SOJ Pharm Pharm Sci.
2017 | journal-article
Flavonoids as potential reversing agents of the pharmacoresistance to antiepileptic drugs mediated by the P-glycoprotein
12th European Congress on Epileptology
2016 | conference-poster
Early results of next-gen cytogenetics implementation in Portugal
European Human Genetics Conference 2016
2016 | conference-paper
P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review.
Natural product communications
2016 | journal-article
A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.
International journal of pharmaceutics
2016 | journal-article
Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.
Biomedical chromatography : BMC
2016 | journal-article
Pharmacokinetics of opicapone, a novel catechol-O-methyltransferase inhibitor, in the Wistar rat
Parkinsonism & Related Disorders
2016 | journal-article
A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.
International Journal of Pharmaceutics.
2016 | journal-article
Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.
Current drug metabolism
2016 | journal-article
Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.
Curr Drug Metab.
2016 | journal-article
Huperzine A from Huperzia serrata: a review os its sources, chemistry, pharmacology and toxicology.
Phytochemistry Reviews.
2016 | journal-article
P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review
Natural product Communications
2016 | journal-article
Amikacin plasma monitoring in treating Portuguese patients infected with Acinetobacter baumannii
44th ESCP Symposium on Clinical Pharmacy Lisbon, Portugal
2015 | conference-poster
Phenytoin in pediatric patients: How important is the AEDs therapeutic drug monitoring?
44th ESCP Symposium on Clinical Pharmacy
2015 | conference-poster
2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development
Biomedical Chemistry
2015 | book-chapter
Development of a liquid chromatography assay for the determination of opicapone and BIA 9–1079 in rat matrices
Biomedical Chromatography
2015 | journal-article
Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice
International Journal of Pharmaceutics
2015 | journal-article
Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice
International Journal of Pharmaceutics
2015 | journal-article
Pharmacokinetics and Bioanalysis to Improve Drug Development: focus on pharmacokinetic studies
BIOMEDICAL CHEMISTRY - CURRENT TRENDS AND DEVELOPMENTS
2015 | book-chapter
Pharmacokinetics and bioanalysis to improve drug development
Biomedical Chemistry: Current Trends and Developments
2015 | book
The Pharmacology of Simvastatin: from the mechanism of action to new therapeuticapplications
SIMVASTATIN DELIVERY: CHALLENGES AND OPPORTUNITIES
2015 | book-chapter
The pharmacology of simvastatin: From the mechanism of action to new therapeutic applications
Simvastatin Delivery: Challenges and Opportunities
2015 | book
Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
Phytochemistry Reviews
2014 | journal-article
Development of a new PAMPA method for the prediction of blood-brain barrier permeation using an in-house brain lipid extract
17th International Symposium on Signal Transduction at the Blood-Brain and Blood-Retina Barriers
2014 | conference-poster
Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting
European Journal of Pharmaceutical Sciences
2014 | journal-article
Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats
Journal of Pharmacy & Pharmaceutical Sciences
2014 | journal-article
Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology
Phytochemistry Reviews
2014 | journal-article
Avaliação do potencial da via intranasal para a administração de fármacos antiepiléticos: aplicação à carbamazepina
26º Encontro Nacional de Epileptologia
2014 | conference-poster
Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety
2014 | journal-article
A new MEPS/HPLC assay to quantify venlafaxine and its main metabolite in human plasma
43rd European Symposium on Clinical Pharmacy
2014 | conference-poster
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Chiral chromatographic resolution of antiepileptic drugs and their metabolites: A challenge from the optimization to the application
Biomedical Chromatography
2014 | journal-article
Direct nose-to-brain delivery of carbamazepine after intranasal administration to mice.
9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
2014 | conference-paper
Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology
Phytochemistry Reviews
2014 | journal-article
Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats.
Journal of Pharmacy and Pharmaceutical Sciences
2014 | journal-article
Identification of P-glycoprotein inhibitors in Caco 2 cells: An in vitro screening methodology
9th World Meeting on Pharmaceutics
2014 | conference-paper
Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting.
European Journal of Pharmaceutical Sciences
2014 | journal-article
Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules.
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
2014 | journal-article
Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2014 | journal-article
Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine.
Journal of Chromatography B,
2014 | journal-article
Medication regimen complexity evaluation in a hypertensive Portuguese population
43rd European Symposium on Clinical Pharmacy
2014 | conference-poster
Third- and Fourth-generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety
2014 | journal-article
An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.
The Analyst
2013 | journal-article
A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis
Bioanalysis
2013 | journal-article
First HPLC-UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in human plasma
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2013 | journal-article
First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2013 | journal-article
Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples - A review
Analytica Chimica Acta
2013 | journal-article
Nose as a Route for Drug Delivery
Nasal Physiology and Pathophysiology of Nasal Disorders
2013 | book-chapter
Nose as a route for drug delivery
NASAL PHYSIOLOGY AND PATHOPHYSIOLOGY OF NASAL DISORDERS
2013 | book-chapter
Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models
Epilepsy Research
2013 | journal-article
Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.
Epilepsy Research.
2013 | journal-article
In vitro screening and in vivo preclinical models fo r pharmacokinetic evaluation of carbamazepine and derivatives
Conferência Centro de Estudos Farmacêuticos (CEF)
2012 | conference-poster
A new parallel artificial membrane permeability assay for estimation of intestinal absorption and protein binding in drug discovery programs
6th European Congress of Pharmacology, EPHAR 20 12
2012 | conference-poster
Development of an in vitro bidirectional transport model for prediction of human drug absorption and assessment of P-glycoprotein involvement in intestinal drug absorption.
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Fast HPLC-UV method for the simultaneous de termination of carbamazepine, lamotrigine, oxcarbazepine and phenytoin in mouse plasma, brain and liver tissues.
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Influence of plasma protein binding and efflux transport mediated by P-glycoprotein on the enantioselective biodisposition of eslicarbazepine and R-licarbazepine.
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Plasma and brain pharmacokinetic profiles of carbamazepine and nine derivatives after oral administration to mice: implications for selection of drug candidates.
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Quantification of ciprofloxacin in plasma and nasal mucosa matrices by high-performance liquid chromatography with fluorescence detection
6th European Congress of Pharmacology, EPHAR
2012 | conference-poster
Avaliação farmacométrica in silico, in vitro e in viv o da carbamazepina e análogos estruturais.
24º Encontro Nacional de Epileptologia
2012 | conference-poster
A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain
Biomedical Chromatography
2012 | journal-article
Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review
Analytical and Bioanalytical Chemistry
2012 | journal-article
Erratum: Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review (Analytical and Bioanalytical Chemistry DOI: 10.1007/s00216-011-5706-8)
Analytical and Bioanalytical Chemistry
2012 | journal-article
Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique
Epilepsia
2012 | journal-article
Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: Application to dibenz[b,f]azepine-5-carboxamide derivatives
Journal of Pharmaceutical Sciences
2012 | journal-article
Análise farmacométrica de derivados da carbamazepina: avaliação in vitro, in vivo e in silico das suas propriedades farmacológicas
Universidade de Coimbra
2011 | dissertation-thesis
A rapid and robust HPLC-UV method for simultaneous quantification of three generations of anti-epileptic drugs in human plasma: carbamazepine, oxcarbazepine and eslicarbazepine acetate.
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
Assessment of the involvement of P-glycoprotein in intestinal drug absorption during drug discovery
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
Determination of norfloxacin, ciprofloxacin and lemofloxacin in hum an plasma by a simple and rapid liquid chromatographic method.
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
Development of an enantioselective high performance liquid chromatography analysis of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain.
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
Predicting human drug absorption with Parallel Artificial Membrane Permeability Assay.
Conferência Ibero-Americana de Faculdades de Farmácia
2011 | conference-poster
A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites
Journal of Separation Science
2011 | journal-article
Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma
Biomedical Chromatography
2011 | journal-article
In Vitro?In Vivo Correlation (IVIVC): A Strategic Tool in Drug Development
Journal of Bioequivalence & Bioavailability
2011 | journal-article
Novel HPLC-UV method to monitor plasma concentrations of six antiepileptic drugs and three of their main metabolites in patients with epilepsy.
Conferência Ibero-America na de Faculdades de Farmácia
2011 | conference-poster
A rapid and sensitive high-performance liquid chromatographic method to quantify carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.
WorldPharma2010 16th IUPHAR World Congress on Basis and Clinical Pharmacology
2010 | conference-poster
BIOMEDICAL CHROMATOGRAPHY - Bioanalysis in drug discovery and development: focus on pharmacokinetic studies.
2010 | book-chapter
Binding of licarbazepine enantiomers to mouse and human plasma proteins
Biopharmaceutics and Drug Disposition
2010 | journal-article
Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies
Biomedical Chromatography
2010 | book
Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma
Analytical and Bioanalytical Chemistry
2010 | journal-article
Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites
Therapeutic Drug Monitoring
2010 | journal-article
Lack of interference of Carbamazepine and its metabolites in the enantioselective therapeutic drug monitoring of eslicarbazepine acetate
WorldPharma2010 16th I UPHAR World Congress on Basis and Clinical Pharmacology
2010 | conference-poster
Morphological evaluation of rat liver tissue after the subcutaneous injection of 1,2-dimethylhydrazine
WorldPharma2010 16th IUPHAR World Congress on Basis and Clinical Pharmacology
2010 | conference-poster
Kidney drug exposure after multiple-dose administration of S- and R-licarbazepine to mice
38th American College of Clinical Pharmacology Annual Meeting. San Antonio (Texas)/Estados Unidos da América,
2009 | conference-poster
Plasma-brain distribution of licarbazapine enantiomers in mice on steady-state conditions
38th American College of Clinical Pharmacology Annual Meeting
2009 | conference-poster
Human plasma protein binding of S- and R-licarbazepine
XVIII CONGRESO de la Asociación Latinoamericana de Farmacología; XXX Reunión Anual Socie dad de Farmacología de Chile; XXIII Sociedad Chilena de Ciencias Fisiológicas; III Congreso Iberoamericano de Farmacología.
2009 | conference-poster
Intranasal drug delivery: How, why and what for?
Journal of Pharmacy and Pharmaceutical Sciences
2009 | journal-article
Metabolism and liver pharmacokinetics of S- and R-licarbazepine in mice at the steady-state.
38th American College of Clinical Pharmacology Annual Meeting
2009 | conference-poster
Plasma-brain distribution of licarbazepine enantiomers in mice on steady-state conditions.
38th American College of Clinical Pharmacology Annual Meeting
2009 | conference-poster
Plasma protein binding of licarbazepine enantiomers in human and mouse species.
1st International Epilepsy Colloquium
2008 | conference-poster
Binding of licarbazepine enantiomers to human serum albumin and alpha-1-a cid glycoprotein.
XVIII CONGRESO de la Asociación Latinoamericana de Farmacología; XXX Reunión Anual Socie dad de Farmacología de Chile; XXIII Sociedad Chilena de Ciencias Fisiológicas; III Congreso Iberoamericano de Farmacología.
2008 | conference-poster
Warfarin binding to human plasma proteins
2008 | other
Enantioselective HPLC-UV Assay for Eslicarbazepine Acetate (BIA 2-093) and its metabolites determination in mice plasma and tissues: application to pharmacokinetic studies.
Pharmaceutical Sciences World Congress (PSWC) 3rd World Congress of the Board of Pharmaceutical Sciences of FIP.
2007 | conference-poster
Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma
Biomedical Chromatography
2007 | journal-article
Lamotrigine in patients submitted to video-electroencephalographic monitoring : effect of co-medication in temporal and extratemporal epilepsy
1st International Epilepsy Colloquium.
2007 | conference-poster
The importance of permeability screening in drug discovery process: PAMPA, Caco-2 and rat everted gut assays
Current Topics in Pharmacology
2007 | journal-article
High-Performance Liquid Chromatography and its Impact in the Development of Chiral Drugs: a Review
Trends in Chromatography
| journal-article