Algoritmi | User | Ana Cristina Bairrada Fortuna


Ana Cristina Bairrada Fortuna

Ana Cristina Bairrada Fortuna
Personal Email
anacfortuna@gmail.comOrcid
0000-0001-6981-6639Researcher ID
FCT Public Key
Ciência ID
E510-8BF0-1756Google Scholar
About Me
Ana Fortuna is graduated in Pharmaceutical Sciences since 2007 and obtained her PhD degree in Pharmaceutical Sciences, specialty of Pharmacology, in 2011 at the Faculty of Pharmacy of University of Coimbra (FFUC). Ana Fortuna holds European Certified Pharmacologist (EuCP) since 2021 and she received 11 national/international awards, including the World's Top 2% Scientists of 2022. She is an Assistant Professor at FFUC since 2011 in the area of Pharmacology and Pharmaceutical Care and an integrated researcher at the Coimbra Institute for Biomedical Imaging and Translational Research of University of Coimbra (CIBIT). She is currently the supervisor of 5 PhD students (1 in collaboration with the pharmaceutical industry, 2 with University of Barcelona and 1 with CHUC), co-supervisor of 2 PhD students and supervisor of 3 Master students in Applied Pharmacology. She has already successfully supervised 2 PhD students, 20 master's students and 29 integrated master's degree students. With a SCOPUS H-INDEX of 28 and 2548 total CITATIONS (Google Scholar: H-index 32 and 3542 citations), Ana Fortuna published 97 articles in international journals; among them, she was the first/last author or the corresponding author of 40 manuscripts. She is also the author of 1 Editorial, 11 book chapters, and more than 100 oral/poster communications at scientific meetings and 3 international patents. She is the principal investigator of the project CENTRO-01-0145-FEDER-030752 (2018-2022) and SustaINsafety (financed by INOVC+), both aiming at developing Nose-to-Brain systems for the treatment of drug-resistant depression. In parallel, Ana Fortuna integrates 7 more funded projects. Her main research areas include: interaction between drugs and efflux transporters, in vitro/in vivo pharmacokinetics and pharmacodynamics of new drugs for depression, epilepsy and Alzheimer´s disease, as well as development/validation of bioanalytical techniques that are employed on drug pharmacokinetics monitoring throughout a personalized pharmacotherapy. These researches allowed Ana Fortuna to establish different collaborations, namely with pharmaceutical industries (Laboratórios BIAL, Hovione, Aptar Pharma), Centro Hospitalar e Universitário de Coimbra (CHUC, EPE, Coimbra, Portugal) and other public national (Universidade da Beira Interior, Universidade do Porto, Universidade de Aveiro and Universidade do Algarve). At the international level, she collaborates with recognized researchers from Spain (Univ. of Barcelona and Univ. of Salamanca), Italy (University of Parma), Germany (Biberach University of Applied Sciences) and Brazil (Universidade Federal de São Paulo).
Publications (156)
Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma
2023 | conference-paper
Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
International Journal of Molecular Sciences
2023 | journal-article
Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics
Journal of Pharmaceutical Investigation
2023 | journal-article
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?
Ageing Research Reviews
2023 | journal-article
Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability
International Journal of Pharmaceutics
2023 | journal-article
Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy
Pharmaceutics
2023 | journal-article
Air-liquid interface (ALI) impact on different respiratory cell cultures
European Journal of Pharmaceutics and Biopharmaceutics
2023 | journal-article
Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients
Antibiotics
2023 | journal-article
From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder
Biochemical Pharmacology
2022 | journal-article
Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma
Molecular Genetics and Genomics
2022 | journal-article
A Stepwise Framework for the Systematic Development of Lipid Nanoparticles
Biomolecules
2022 | journal-article
INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS
2022 | patent
Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug
PBP World Meeting 2022
2022 | conference-poster
SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES
2022 | patent
Therapeutic drug monitoring of clozapine on patients with refractory schizophrenia
ESCP 2021 Virtual Symposium- Clinical pharmacy
2021 | conference-poster
The impact of smoking habits and comedicated drugs on clozapine/norclozapine ratios
4º Encontro SPFCS
2021 | conference-poster
The essential oil from the fruits of Peucedanum oreoselinum (L.) Moench (Apiaceae) as a natural source of P-glycoprotein inhibitors
Journal of Herbal Medicine
2021 | journal-article
Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review
Journal of Pharmaceutical Analysis
2021 | journal-article
Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach
Chemosensors
2021 | journal-article
Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies
RDD 2021
2021 | conference-poster
In vitro release methodologies for nasal powder testing
PBP World Meeting
2021 | conference-poster
HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring
Journal of Pharmaceutical and Biomedical Analysis
2021 | journal-article
Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications
Life Sciences
2021 | journal-article
Quantificação de fármacos antiepiléticos em saliva humana como uma nova ferramenta de monitorização da terapêutica
33º Encontro Nacional de Epileptologia
2021 | conference-poster
Is intranasal administration an opportunity for direct brain delivery of lacosamide?
European Journal of Pharmaceutical Sciences
2021 | journal-article
A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration
International Journal of Pharmaceutics
2021 | journal-article
Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients
Journal of Chromatography B
2021 | journal-article
Benchmarking of particle engineering technologies for nasal powder manufacture
DDL 2020
2020 | conference-poster
Cystic fibrosis: Physiopathology and the latest pharmacological treatments
Pharmacological Research
2020 | journal-article
Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders
Pharmacological Research
2020 | journal-article
Salting-out assisted liquidliquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices
Journal of Separation Science
2020 | journal-article
Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy
Pharmaceutics
2020 | journal-article
Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment
European Journal of Pharmaceutics and Biopharmaceutics
2020 | journal-article
Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics
British Journal of Pharmacology
2020 | journal-article
Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
Pharmaceutical Research
2020 | journal-article
Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders
Current Pharmaceutical Design
2020 | journal-article
Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review
British Journal of Clinical Pharmacology
2020 | journal-article
Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.
Drug Repurposing in Cancer Therapy: Approaches and Applications
2020 | book-chapter
Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy
2020 | patent
Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development
Nanotherapy for Brain Tumor Drug Delivery
2020 | book-chapter
Establishing xenograft glioblastoma models for use in preclinical development
Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series
2020 | book-chapter
Novel Routes to Accessing the Brain: Intranasal Administration
Nanoparticles for Brain Drug Delivery
2020 | book-chapter
QbD-driven development of intranasal lipid nanoparticles for depression treatment
European Journal of Pharmaceutics and Biopharmaceutics
2020 | journal-article
Understanding brain delivery
Nanoparticles for Brain Drug Delivery
2020 | book-chapter
How does the device determine nose-to-brain drug delivery to mice?
Drug Delivery to the Lungs (DDL 2019)
2019 | conference-poster
Nasal powder delivery: a step towards a biorelevant dissolution system
Drug Delivery to the Lungs (DDL2019)
2019 | conference-poster
Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic SyndromeReview of Classical and New Compounds: Part-I
Pharmaceuticals
2019 | journal-article
Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: the complexity of dose adjustments
48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)
2019 | conference-poster
Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review
Analytica Chimica Acta
2019 | journal-article
Pharmacokinetic data model on assessing adherence to levetiracetam
48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)
2019 | conference-poster
Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies
Journal of Chromatography B
2019 | journal-article
Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice
Biomedical Chromatography
2019 | journal-article
Direct oral anticoagulants (DOACs) adjustment in patients with cardiac implantable devices and non-valvular atrial fibrillation, foccusing on renal adjustment: a single-centre retrospective study
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Nose-to-brain delivery of levetiracetam: preclinical evidence
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Therapeutic drug monitoring of levetiracetam: Pharmacokinetic characterization and compliance assessment of epileptic patients
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Nose-to-brain delivery of levetiracetam after intranasal administration to mice
International Journal of Pharmaceutics
2019 | journal-article
Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics and clinical outcomes: GnG-PK/PD-AD study
Experimental and Clinical Psychopharmacology
2019 | journal-article
Silymarin as a Flavonoid-Type P-Glycoprotein Inhibitor with impact on the Pharmacokinetics of Carbamazepine, Oxcarbazepine and Phenytoin in Rats
Drug and Chemical Toxicology
2019 | journal-article
ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches
Pharmacological Research
2019 | journal-article
Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges
Drug Discovery Today
2019 | journal-article
Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia
31º Encontro Nacional de Epileptologia
2019 | conference-poster
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices
Journal of Pharmaceutical Analysis
2019 | journal-article
First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study
The Analyst
2019 | journal-article
Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff
Advances in Processing Technologies for Bio-based Nanosystems in Food
2019 | book-chapter
Real-World Clinical Characterization of Subjects With Depression Treated With Antidepressant Drugs Focused on (Non-)Genetic Factors, Pharmacokinetics, and Clinical Outcomes: GnG-PK/PD-AD Study
Experimental and Clinical Psychopharmacology
2019 | journal-article
Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles
International Journal of Pharmaceutics
2019 | journal-article
Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats
Drug and Chemical Toxicology
2019 | journal-article
Application of pharmacokinetic monitoring of amikacin in its pharmacological effects
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective
Current Drug Metabolism
2018 | journal-article
In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.
Epilepsy Res.
2018 | journal-article
ADME-T and pharmacokinetic parameters of antitrypanosomal/antitumoral analogues of licarin A
41ª Reunião Anual da Sociedade Brasileira de Química
2018 | conference-poster
Desenvolvimento e validação de uma nova metodologia de quantificação simultânea da lacosamida, levetiracetam e zonisamida em plasma de doentes epilépticos
30º Encontro Nacional de Epileptologia
2018 | conference-poster
Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.
Bioanalysis
2018 | journal-article
In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2018 | journal-article
Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.
Food research international.
2018 | journal-article
Development and validation of an HPLC-FLD technique for colistin quantification and its plasma monitoring in hospitalized patients
Analytical Methods
2018 | journal-article
Evaluation of the pharmacokinetics of amikacin in neutropenic cancer patients: influence of cancer pathology and chemotherapy
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Genetic characterization of the CYP2C9, CYP2C19, CYP2D6 isoenzymes and P-glycoprotein in Portuguese depressive patients
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy
Epilepsy Research
2018 | journal-article
Levetiracetam therapy individualization: predictive performance of three pharmacokinetic models
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Microextraction Techniques in LC-MS Bioanalysis
Sample Preparation in LC-MS Bioanalysis
2018 | book-chapter
Monitoring lacosamide, levetiracetam, zonisamide in plasma of epileptic patients: personalizing the pharmacotherapy of levetiracetam
47th ESPC Symposium on Clinical Pharmacy
2018 | conference-poster
Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors.
Drug metabolism and disposition: the biological fate of chemicals
2017 | journal-article
Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study.
Pharmaceutical research
2017 | journal-article
Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2017 | journal-article
A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.
Neuropharmacology
2017 | journal-article
Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.
Toxicology and applied pharmacology
2017 | journal-article
Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2017 | journal-article
Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
2017 | journal-article
Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy
Bioequivalence & Bioavailability International Journal.
2017 | journal-article
Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy
Bioequivalence & Bioavailability International Journal
2017 | journal-article
Flavonoid compounds as reversing agents of the P-glycoproteinmediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.
Food Research International.
2017 | magazine-article
Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats.
Food and Chemical Toxicology.
2017 | journal-article
Pharmacokinetics of Cymbopogon citratus Infusion in Rats after Single Oral Dose Administration.
SOJ Pharm Pharm Sci.
2017 | journal-article
P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review.
Natural product communications
2016 | journal-article
A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.
International journal of pharmaceutics
2016 | journal-article
Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.
Biomedical chromatography : BMC
2016 | journal-article
Pharmacokinetics of opicapone, a novel catechol-O-methyltransferase inhibitor, in the Wistar rat
Parkinsonism & Related Disorders
2016 | journal-article
A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.
International Journal of Pharmaceutics.
2016 | journal-article
Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.
Current drug metabolism
2016 | journal-article
Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.
Curr Drug Metab.
2016 | journal-article
Huperzine A from Huperzia serrata: a review os its sources, chemistry, pharmacology and toxicology.
Phytochemistry Reviews.
2016 | journal-article
P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review
Natural product Communications
2016 | journal-article
Amikacin plasma monitoring in treating Portuguese patients infected with Acinetobacter baumannii
44th ESCP Symposium on Clinical Pharmacy Lisbon, Portugal
2015 | conference-poster
2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development
Biomedical Chemistry
2015 | book-chapter
A new MEPS/HPLC assay to quantify venlafaxine and its main metabolite in human plasma
2015 | other
Development of a liquid chromatography assay for the determination of opicapone and BIA 9–1079 in rat matrices
Biomedical Chromatography
2015 | journal-article
Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice
International Journal of Pharmaceutics
2015 | journal-article
Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice
International Journal of Pharmaceutics
2015 | journal-article
Pharmacokinetics and Bioanalysis to Improve Drug Development: focus on pharmacokinetic studies
BIOMEDICAL CHEMISTRY - CURRENT TRENDS AND DEVELOPMENTS
2015 | book-chapter
Pharmacokinetics and bioanalysis to improve drug development
Biomedical Chemistry: Current Trends and Developments
2015 | book
The Pharmacology of Simvastatin: from the mechanism of action to new therapeuticapplications
SIMVASTATIN DELIVERY: CHALLENGES AND OPPORTUNITIES
2015 | book-chapter
The pharmacology of simvastatin: From the mechanism of action to new therapeutic applications
Simvastatin Delivery: Challenges and Opportunities
2015 | book
Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
Phytochemistry Reviews
2014 | journal-article
Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting
European Journal of Pharmaceutical Sciences
2014 | journal-article
Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats
Journal of Pharmacy & Pharmaceutical Sciences
2014 | journal-article
Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology
Phytochemistry Reviews
2014 | journal-article
Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety
2014 | journal-article
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Chiral chromatographic resolution of antiepileptic drugs and their metabolites: A challenge from the optimization to the application
Biomedical Chromatography
2014 | journal-article
Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology
Phytochemistry Reviews
2014 | journal-article
Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats.
Journal of Pharmacy and Pharmaceutical Sciences
2014 | journal-article
Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting.
European Journal of Pharmaceutical Sciences
2014 | journal-article
Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules.
European Journal of Pharmaceutics and Biopharmaceutics
2014 | journal-article
Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
2014 | journal-article
Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2014 | journal-article
Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine.
Journal of Chromatography B,
2014 | journal-article
Third- and Fourth-generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety
2014 | journal-article
An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.
The Analyst
2013 | journal-article
A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis
Bioanalysis
2013 | journal-article
First HPLC-UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in human plasma
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2013 | journal-article
First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2013 | journal-article
Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples - A review
Analytica Chimica Acta
2013 | journal-article
Nose as a Route for Drug Delivery
Nasal Physiology and Pathophysiology of Nasal Disorders
2013 | book-chapter
Nose as a route for drug delivery
NASAL PHYSIOLOGY AND PATHOPHYSIOLOGY OF NASAL DISORDERS
2013 | book-chapter
Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models
Epilepsy Research
2013 | journal-article
Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.
Epilepsy Research.
2013 | journal-article
A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain
Biomedical Chromatography
2012 | journal-article
Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review
Analytical and Bioanalytical Chemistry
2012 | journal-article
Erratum: Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review (Analytical and Bioanalytical Chemistry DOI: 10.1007/s00216-011-5706-8)
Analytical and Bioanalytical Chemistry
2012 | journal-article
Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique
Epilepsia
2012 | journal-article
Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: Application to dibenz[b,f]azepine-5-carboxamide derivatives
Journal of Pharmaceutical Sciences
2012 | journal-article
Análise farmacométrica de derivados da carbamazepina: avaliação in vitro, in vivo e in silico das suas propriedades farmacológicas
Universidade de Coimbra
2011 | dissertation-thesis
A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites
Journal of Separation Science
2011 | journal-article
Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma
Biomedical Chromatography
2011 | journal-article
In Vitro?In Vivo Correlation (IVIVC): A Strategic Tool in Drug Development
Journal of Bioequivalence & Bioavailability
2011 | journal-article
BIOMEDICAL CHROMATOGRAPHY - Bioanalysis in drug discovery and development: focus on pharmacokinetic studies.
2010 | book-chapter
Binding of licarbazepine enantiomers to mouse and human plasma proteins
Biopharmaceutics and Drug Disposition
2010 | journal-article
Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies
Biomedical Chromatography
2010 | book
Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma
Analytical and Bioanalytical Chemistry
2010 | journal-article
Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites
Therapeutic Drug Monitoring
2010 | journal-article
Intranasal drug delivery: How, why and what for?
Journal of Pharmacy and Pharmaceutical Sciences
2009 | journal-article
Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma
Biomedical Chromatography
2007 | journal-article
The importance of permeability screening in drug discovery process: PAMPA, Caco-2 and rat everted gut assays
Current Topics in Pharmacology
2007 | journal-article
High-Performance Liquid Chromatography and its Impact in the Development of Chiral Drugs: a Review
Trends in Chromatography
| journal-article
Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma
2023 | conference-paper
Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
International Journal of Molecular Sciences
2023 | journal-article
Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics
Journal of Pharmaceutical Investigation
2023 | journal-article
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?
Ageing Research Reviews
2023 | journal-article
Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability
International Journal of Pharmaceutics
2023 | journal-article
Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy
Pharmaceutics
2023 | journal-article
Air-liquid interface (ALI) impact on different respiratory cell cultures
European Journal of Pharmaceutics and Biopharmaceutics
2023 | journal-article
Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients
Antibiotics
2023 | journal-article
From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder
Biochemical Pharmacology
2022 | journal-article
Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma
Molecular Genetics and Genomics
2022 | journal-article
A Stepwise Framework for the Systematic Development of Lipid Nanoparticles
Biomolecules
2022 | journal-article
INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS
2022 | patent
Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug
PBP World Meeting 2022
2022 | conference-poster
SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES
2022 | patent
Therapeutic drug monitoring of clozapine on patients with refractory schizophrenia
ESCP 2021 Virtual Symposium- Clinical pharmacy
2021 | conference-poster
The impact of smoking habits and comedicated drugs on clozapine/norclozapine ratios
4º Encontro SPFCS
2021 | conference-poster
The essential oil from the fruits of Peucedanum oreoselinum (L.) Moench (Apiaceae) as a natural source of P-glycoprotein inhibitors
Journal of Herbal Medicine
2021 | journal-article
Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review
Journal of Pharmaceutical Analysis
2021 | journal-article
Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach
Chemosensors
2021 | journal-article
Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies
RDD 2021
2021 | conference-poster
In vitro release methodologies for nasal powder testing
PBP World Meeting
2021 | conference-poster
HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring
Journal of Pharmaceutical and Biomedical Analysis
2021 | journal-article
Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications
Life Sciences
2021 | journal-article
Quantificação de fármacos antiepiléticos em saliva humana como uma nova ferramenta de monitorização da terapêutica
33º Encontro Nacional de Epileptologia
2021 | conference-poster
Is intranasal administration an opportunity for direct brain delivery of lacosamide?
European Journal of Pharmaceutical Sciences
2021 | journal-article
A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration
International Journal of Pharmaceutics
2021 | journal-article
Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients
Journal of Chromatography B
2021 | journal-article
Benchmarking of particle engineering technologies for nasal powder manufacture
DDL 2020
2020 | conference-poster
Cystic fibrosis: Physiopathology and the latest pharmacological treatments
Pharmacological Research
2020 | journal-article
Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders
Pharmacological Research
2020 | journal-article
Salting-out assisted liquidliquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices
Journal of Separation Science
2020 | journal-article
Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy
Pharmaceutics
2020 | journal-article
Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment
European Journal of Pharmaceutics and Biopharmaceutics
2020 | journal-article
Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics
British Journal of Pharmacology
2020 | journal-article
Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
Pharmaceutical Research
2020 | journal-article
Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders
Current Pharmaceutical Design
2020 | journal-article
Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review
British Journal of Clinical Pharmacology
2020 | journal-article
Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.
Drug Repurposing in Cancer Therapy: Approaches and Applications
2020 | book-chapter
Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy
2020 | patent
Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development
Nanotherapy for Brain Tumor Drug Delivery
2020 | book-chapter
Establishing xenograft glioblastoma models for use in preclinical development
Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series
2020 | book-chapter
Novel Routes to Accessing the Brain: Intranasal Administration
Nanoparticles for Brain Drug Delivery
2020 | book-chapter
QbD-driven development of intranasal lipid nanoparticles for depression treatment
European Journal of Pharmaceutics and Biopharmaceutics
2020 | journal-article
Understanding brain delivery
Nanoparticles for Brain Drug Delivery
2020 | book-chapter
How does the device determine nose-to-brain drug delivery to mice?
Drug Delivery to the Lungs (DDL 2019)
2019 | conference-poster
Nasal powder delivery: a step towards a biorelevant dissolution system
Drug Delivery to the Lungs (DDL2019)
2019 | conference-poster
Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic SyndromeReview of Classical and New Compounds: Part-I
Pharmaceuticals
2019 | journal-article
Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: the complexity of dose adjustments
48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)
2019 | conference-poster
Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review
Analytica Chimica Acta
2019 | journal-article
Pharmacokinetic data model on assessing adherence to levetiracetam
48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)
2019 | conference-poster
Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies
Journal of Chromatography B
2019 | journal-article
Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice
Biomedical Chromatography
2019 | journal-article
Direct oral anticoagulants (DOACs) adjustment in patients with cardiac implantable devices and non-valvular atrial fibrillation, foccusing on renal adjustment: a single-centre retrospective study
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Nose-to-brain delivery of levetiracetam: preclinical evidence
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Therapeutic drug monitoring of levetiracetam: Pharmacokinetic characterization and compliance assessment of epileptic patients
53rd Annual Scientific Meeting of the European Society for Clinical Investigation
2019 | conference-poster
Nose-to-brain delivery of levetiracetam after intranasal administration to mice
International Journal of Pharmaceutics
2019 | journal-article
Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics and clinical outcomes: GnG-PK/PD-AD study
Experimental and Clinical Psychopharmacology
2019 | journal-article
Silymarin as a Flavonoid-Type P-Glycoprotein Inhibitor with impact on the Pharmacokinetics of Carbamazepine, Oxcarbazepine and Phenytoin in Rats
Drug and Chemical Toxicology
2019 | journal-article
ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches
Pharmacological Research
2019 | journal-article
Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges
Drug Discovery Today
2019 | journal-article
Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia
31º Encontro Nacional de Epileptologia
2019 | conference-poster
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices
Journal of Pharmaceutical Analysis
2019 | journal-article
First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study
The Analyst
2019 | journal-article
Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff
Advances in Processing Technologies for Bio-based Nanosystems in Food
2019 | book-chapter