Algoritmi | User | Ana Cristina Bairrada Fortuna

Ana Cristina Bairrada Fortuna

Ana Cristina Bairrada Fortuna

At LASI

Member of the CIBIT R&D Unit

Academic Degree

Current Position

at

Personal Webpage

Personal Email

anacfortuna@gmail.com

Orcid

0000-0001-6981-6639

Researcher ID

FCT Public Key

Ciência ID

E510-8BF0-1756

Google Scholar

About Me



Chronopharmacokinetics of the antidepressant paroxetine: An in vitro and in vivo approach

Neuropharmacology

2025 | journal-article

Population pharmacokinetics of levetiracetam in patients diagnosed with refractory epilepsy: A real‐world study

Epilepsia

2025 | journal-article

A new population pharmacokinetic model for dosing optimization of zonisamide in patients with refractory epilepsy

European Journal of Pharmaceutical Sciences

2025 | journal-article

Pharmacokinetics of Non-Psychotropic Phytocannabinoids

Pharmaceutics

2025 | journal-article

Therapeutic effect of cyclosporine A-loading TPGS micelles on a mouse model of LPS-induced neuroinflammation

European Journal of Pharmaceutical Sciences

2025 | journal-article

Sex-dependent cortical morphometric and neurophysiological alterations in a genetic mouse model of tuberous sclerosis complex 2

3rd Annual Meeting of Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT)

2024 | conference-poster

Are we better together? Addressing a combined treatment of pitavastatin and temozolomide for brain cancer

European Journal of Pharmacology

2024 | journal-article

Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

Biomedicine & Pharmacotherapy

2024 | journal-article

Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan

Biochemical Pharmacology

2024 | journal-article

Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for?

Ageing Research Reviews

2024 | journal-article

Drug–Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain

Pharmaceuticals

2024 | journal-article

Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences

Biochemical Pharmacology

2024 | journal-article

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Acta Pharmacologica Sinica

2024 | journal-article

Possible relationship between tryptophan metabolism, serotonergic function and E/I neurotransmitters in Tuberous Sclerosis Complex 2

EMIM 2024

2024 | conference-poster

Enhancing glioblastoma therapy through lipid nanoparticle-mediated drug and gene co-delivery

XVth SPLC-CRS Conference on Controlled Drug Delivery: "New Horizons in Drug Delivery"

2024 | conference-poster

Intranasal irbesartan reverts cognitive decline and activates the PI3K/AKT pathway in an LPS-induced neuroinflammation mice model

International Immunopharmacology

2024 | journal-article

Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression

European Journal of Pharmaceutics and Biopharmaceutics

2024 | journal-article

Cannabinoid Modulation of Monoamine Levels in Mouse Brain: Unveiling Neurochemical Dynamics through an Innovative High-performance Liquid Chromatography-Fluorescence Detection Bioanalysis

Journal of Analysis and Testing

2024 | journal-article

Development and validation of an HPLC-DAD method for the quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene in human plasma and mouse matrices

The Analyst

2024 | journal-article

Intranasal Administration of Irbesartan as a New Strategy for Addressing Neurodegeneration in a Neuroinflammation Mice Model: Pharmacokinetic and Efficacy Evaluation

Congresso do Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra

2024 | conference-poster

The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for?

Ageing Research Reviews

2024 | journal-article

A new bioanalytical tool for neurotransmitter monitoring in central nervous system diseases

2nd Annual Meeting of CIBIT

2023 | conference-poster

Development of a Pharmacokinetic Model for Bayesian Individualization of Oral Levetiracetam in Refractory Epileptic Patients

2nd Annual Meeting of CIBIT

2023 | conference-poster

Negative correlation between cortical tryptophan metabolism and E/I balance in a genetic mouse model of autism spectrum disorders

2nd CIBIT Meeting

2023 | conference-poster

Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol

2023 | preprint

HPLC DAD technique for the quantification of cannabinoids in human plasma and mouse matrices

PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences

2023 | conference-poster

Unveiling the molecular mechanisms of pitavastatin induced glioblastoma death using proteomics

PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences

2023 | conference-poster

Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma

2023 | conference-paper

Decoding the molecular mechanisms of pitavastatin induced glioblastoma death through proteomics

ESN-ISN Neurochemistry School 2023

2023 | conference-poster

Gender Differences During Unpredictable Chronic Mild Stress (UCMS) And Paroxetine Intranasal Administration To Mice

36th ECNP Congress

2023 | conference-poster

Otimização da Entrega de Fármacos com Transportadores Lipídicos Nanoestruturados no Glioblastoma

X Congresso Iberoamericano em Ciências Farmacêuticas

2023 | conference-paper

Ultra High Performance Liquid Chromatography Technique to support Pharmacokinetic Monitoring of Losartan, Irbesartan and Valsartan

X Congresso Iberoamericano de Ciências Farmacêuticas

2023 | conference-poster

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

International Journal of Molecular Sciences

2023 | journal-article

Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics

Journal of Pharmaceutical Investigation

2023 | journal-article

Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?

Ageing Research Reviews

2023 | journal-article

Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability

International Journal of Pharmaceutics

2023 | journal-article

Achieving accurate measurements without breaking the bank: A highly sensitive technique for pitavastatin quantification in human plasma

XXVIII Encontro nacional da Sociedade Portuguesa de Química

2023 | conference-poster

Angiotensin Receptor Blockers as an Alternative Strategy for Addressing Neurodegeneration in a LPS Mice Model

Alzheimer’s Association International Congress

2023 | conference-poster

Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy

Pharmaceutics

2023 | journal-article

Air-liquid interface (ALI) impact on different respiratory cell cultures

European Journal of Pharmaceutics and Biopharmaceutics

2023 | journal-article

High Performance Liquid Chromatography Technique for the Quantification of Cannabigerol, Cannabidiol, Cannabinol and Cannabichromene in human plasma and mice matrix

International Scientific Congress - Clearing the smoke¿.: the importance of the endocannabinoid system in health and disease

2023 | conference-poster

Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients

Antibiotics

2023 | journal-article

Drug and Gene Delivery in Glioblastoma: Friends or Foes?, Delivery of RNA Therapeutics

Delivery of RNA Therapeutics, Final DARTER Meeting

2023 | conference-poster

Physiologically-Based Pharmacokinetic Modeling to Support the Determination of Drug Product Bioequivalence

Time-Proof Perspectives on Bioequivalence

2023 | book-chapter

From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder

Biochemical Pharmacology

2022 | journal-article

Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients

Biomedicines

2022 | journal-article

The quest for better treatments: a novel drug delivery approach to glioblastoma

IX Iberian Meeting on Colloids and Interfaces

2022 | conference-poster

Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel

International Journal of Pharmaceutics

2022 | journal-article

Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model

Toxicology in Vitro

2022 | journal-article

Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma

Molecular Genetics and Genomics

2022 | journal-article

Nose-to-brain delivery of perampanel using a non-toxic self-microemulsion drug delivery system.

52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia

2022 | conference-abstract

A Stepwise Framework for the Systematic Development of Lipid Nanoparticles

Biomolecules

2022 | journal-article

Optimizing nanostructured lipid carriers for the intra nasal administration of paroxetine and escitalopram in the treatment of depression

1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal

2022 | conference-poster

Nasal-PAMPA: a novel in vitro tool for prediction of intranasal drug permeability

Drug Delivery to the Lungs

2022 | conference-abstract

Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug

PBP World Meeting 2022

2022 | conference-poster

New HPLC technology for monitoring neurotransmitters in the brain: a pre-clinical approach for neurological disorders

ternational Multi-Brain Barcelona Congress - Healthy, Pathological and Artificial Brain

2022 | conference-poster

PCT/IB2022/052060 - SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES

2022 | patent

PCT/IB2022/061847 - WO/2023/105415: INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS

2022 | patent

Renin-angiotensin system acting drugs: a possible role in Alzheimer’s disease

International Multi-Brain Barcelona Congress - Healthy, Pathological and Artificial Brain

2022 | conference-poster

Taking the most out of lipids: A systematic design of lipid-based nanoparticles

1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal

2022 | conference-poster

Therapeutic drug monitoring of clozapine on patients with refractory schizophrenia

ESCP 2021 Virtual Symposium- Clinical pharmacy

2021 | conference-poster

DIRECT ORAL ANTICOAGULANTS (DOACS) USE IN PATIENTS WITH CARDIAC IMPLANTABLE DEVICES AND NON-VALVULAR ATRIAL FIBRILLATION: IMPACT OF OFF-LABEL DOSE USE IN SAFETY AND EFFICACY OUTCOMES

ESCP 2021 Symposium: Clinical pharmacy, working collaboratively in mental health care

2021 | conference-poster

The impact of smoking habits and comedicated drugs on clozapine/norclozapine ratios

4º Encontro SPFCS

2021 | conference-poster

The essential oil from the fruits of Peucedanum oreoselinum (L.) Moench (Apiaceae) as a natural source of P-glycoprotein inhibitors

Journal of Herbal Medicine

2021 | journal-article

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review

Journal of Pharmaceutical Analysis

2021 | journal-article

Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach

Chemosensors

2021 | journal-article

Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies

RDD 2021

2021 | conference-poster

In vitro release methodologies for nasal powder testing

PBP World Meeting

2021 | conference-poster

HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring

Journal of Pharmaceutical and Biomedical Analysis

2021 | journal-article

Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications

Life Sciences

2021 | journal-article

Quantification of antiepileptic drugs in human saliva as a new tool of therapeutic monitoring.

33º Nacional Meeting of Epileptology

2021 | conference-poster

Quantificação de fármacos antiepiléticos em saliva humana como uma nova ferramenta de monitorização da terapêutica

 33º Encontro Nacional de Epileptologia

2021 | conference-poster

Is intranasal administration an opportunity for direct brain delivery of lacosamide?

European Journal of Pharmaceutical Sciences

2021 | journal-article

Nose-to-brain delivery of perampanel: a promising therapeutic approach for epilepsy

51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of the Clinical Pharmacology and 20th Meeting of the Toxicology

2021 | conference-abstract

A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration

International Journal of Pharmaceutics

2021 | journal-article

Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients

Journal of Chromatography B

2021 | journal-article

Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: impact of off-label dose use in safety and efficacy outcomes

2021 | other

Benchmarking of particle engineering technologies for nasal powder manufacture

DDL 2020

2020 | conference-poster

Cystic fibrosis: Physiopathology and the latest pharmacological treatments

Pharmacological Research

2020 | journal-article

Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders

Pharmacological Research

2020 | journal-article

Salting-out assisted liquid–liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices

Journal of Separation Science

2020 | journal-article

Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy

Pharmaceutics

2020 | journal-article

Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

British Journal of Pharmacology

2020 | journal-article

Designing Lipid Nanoparticles for Intranasal Delivery of Antidepressants.

Journal of Aerosol Medicine and Pulmonary Drug Delivery

2020 | conference-abstract

Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration

Pharmaceutical Research

2020 | journal-article

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

Current Pharmaceutical Design

2020 | journal-article

Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma

Journal of Pharmaceutical and Biomedical Analysis

2020 | journal-article

Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review

British Journal of Clinical Pharmacology

2020 | journal-article

Avaliação da adesão terapêutica em doentes com epilepsia medicados com levetiracetam recorrendo à monitorização farmacocinética

2020 | other

Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia

2020 | other

Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.

Drug Repurposing in Cancer Therapy: Approaches and Applications

2020 | book-chapter

Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development

Nanotherapy for Brain Tumor Drug Delivery

2020 | book-chapter

Establishing xenograft glioblastoma models for use in preclinical development

Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series

2020 | book-chapter

Nanotechnological approaches in cancer

Drug Repurposing in Cancer Therapy

2020 | book-chapter

Novel Routes to Accessing the Brain: Intranasal Administration

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

PCT/IB2020/061452 - WO/2021/111364A1 : Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy

2020 | patent

QbD-driven development of intranasal lipid nanoparticles for depression treatment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Understanding brain delivery

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

How does the device determine nose-to-brain drug delivery to mice?

Drug Delivery to the Lungs (DDL 2019)

2019 | conference-poster

Nasal powder delivery: a step towards a biorelevant dissolution system

Drug Delivery to the Lungs (DDL2019)

2019 | conference-poster

Application of in vitro nasal model for antidepressant drug permeation studies

1st Annual Meeting in Pharmaceutical Sciences

2019 | conference-poster

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

Pharmaceuticals

2019 | journal-article

Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: the complexity of dose adjustments

48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)

2019 | conference-poster

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review

Analytica Chimica Acta

2019 | journal-article

Pharmacokinetic data model on assessing adherence to levetiracetam

48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)

2019 | conference-poster

Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies

Journal of Chromatography B

2019 | journal-article

Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice

Biomedical Chromatography

2019 | journal-article

Development and validation of the first HPLC method for quantification of perampanel and stiripentol in mouse matrices using an innovator salting-out assisted liquid-liquid extraction procedure optimized by a design of experiments approach

53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI 2019)

2019 | conference-poster

Direct Oral Anticoagulants adjustment in patients with cardiac implantable devices and non-valvular Atrial Fibrillation: A single-centre retrospective study

53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)

2019 | conference-poster

Direct oral anticoagulants (DOACs) adjustment in patients with cardiac implantable devices and non-valvular atrial fibrillation, foccusing on renal adjustment: a single-centre retrospective study

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Nose-to-brain delivery of levetiracetam: preclinical evidence

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Therapeutic drug monitoring of levetiracetam: Pharmacokinetic characterization and compliance assessment of epileptic patients

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Nose-to-brain delivery of levetiracetam after intranasal administration to mice

International Journal of Pharmaceutics

2019 | journal-article

Posters

European Journal of Clinical Investigation

2019 | journal-article

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics and clinical outcomes: GnG-PK/PD-AD study

Experimental and Clinical Psychopharmacology

2019 | journal-article

Silymarin as a Flavonoid-Type P-Glycoprotein Inhibitor with impact on the Pharmacokinetics of Carbamazepine, Oxcarbazepine and Phenytoin in Rats

Drug and Chemical Toxicology

2019 | journal-article

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

Pharmacological Research

2019 | journal-article

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges

Drug Discovery Today

2019 | journal-article

Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia

31º Encontro Nacional de Epileptologia

2019 | conference-poster

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

Journal of Pharmaceutical Analysis

2019 | journal-article

Development and validation of the first HPLC-DAD method for rufinamide quantification in mouse plasma and tissues with focus on future pharmacokinetic studies.

XLIX Reunião da Sociedade Portuguesa de Farmacologia

2019 | conference-abstract

First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study

The Analyst

2019 | journal-article

How does the device determine nose-to-brain drug delivery to mice?

Drug Delivery to the Lungs (DDL 2019)

2019 | conference-paper

Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff

Advances in Processing Technologies for Bio-based Nanosystems in Food

2019 | book-chapter

Real-World Clinical Characterization of Subjects With Depression Treated With Antidepressant Drugs Focused on (Non-)Genetic Factors, Pharmacokinetics, and Clinical Outcomes: GnG-PK/PD-AD Study

Experimental and Clinical Psychopharmacology

2019 | journal-article

Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles

International Journal of Pharmaceutics

2019 | journal-article

Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats

Drug and Chemical Toxicology

2019 | journal-article

Application of pharmacokinetic monitoring of amikacin in its pharmacological effects

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective

Current Drug Metabolism

2018 | journal-article

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.

Epilepsy Res.

2018 | journal-article

ADME-T and pharmacokinetic parameters of antitrypanosomal/antitumoral analogues of licarin A

41ª Reunião Anual da Sociedade Brasileira de Química

2018 | conference-poster

Desenvolvimento e validação de um método para quantificação simultânea de lacosamida, levetiracetam e zonisamida no plasma de doentes epiléticos

Encontro Nacional de Epileptologia

2018 | conference-poster

Desenvolvimento e validação de uma nova metodologia de quantificação simultânea da lacosamida, levetiracetam e zonisamida em plasma de doentes epilépticos

30º Encontro Nacional de Epileptologia

2018 | conference-poster

Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.

Bioanalysis

2018 | journal-article

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2018 | journal-article

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.

Food research international.

2018 | journal-article

Development and validation of an HPLC-FLD technique for colistin quantification and its plasma monitoring in hospitalized patients

Analytical Methods

2018 | journal-article

Evaluation of the pharmacokinetics of amikacin in neutropenic cancer patients: influence of cancer pathology and chemotherapy

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Genetic characterization of the CYP2C9, CYP2C19, CYP2D6 isoenzymes and P-glycoprotein in Portuguese depressive patients

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy

Epilepsy Research

2018 | journal-article

Levetiracetam therapy individualization: predictive performance of three pharmacokinetic models

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Microextraction Techniques in LC-MS Bioanalysis

Sample Preparation in LC-MS Bioanalysis

2018 | book-chapter

Monitoring lacosamide, levetiracetam, zonisamide in plasma of epileptic patients: personalizing the pharmacotherapy of levetiracetam

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-DAD: a tool to perform pharmacokinetic studies.

XIII Annual CICS-UBI Symposium 2018

2018 | conference-abstract

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors.

Drug metabolism and disposition: the biological fate of chemicals

2017 | journal-article

Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study.

Pharmaceutical research

2017 | journal-article

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

Neuropharmacology

2017 | journal-article

Potential of baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin and their dual combinations in reversing the P-glycoprotein-mediated antiepileptic drug resistance

32nd International Epilepsy Congress

2017 | conference-poster

Effects of the silymarin, a P-glycoprotein inhibitor, on the pharmacokinetics of oxcarbazepine and its active metabolite licarbazepine

II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications

2017 | conference-poster

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.

Toxicology and applied pharmacology

2017 | journal-article

Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2017 | journal-article

Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy

Bioequivalence & Bioavailability International Journal.

2017 | journal-article

Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy

Bioequivalence & Bioavailability International Journal

2017 | journal-article

Effect of kidney function on amikacin pharmacokinetics on hospitalized patients: a knowledge to improve therapy

2017 | other

Flavonoid compounds as reversing agents of the P-glycoproteinmediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.

Food Research International.

2017 | magazine-article

High risk of drug-induced phenoconversion and antidepressantdrug interactions at pharmacokinetic level in a naturalistic clinical setting

2017 | other

Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats.

Food and Chemical Toxicology.

2017 | journal-article

Pharmacokinetics of Cymbopogon citratus Infusion in Rats after Single Oral Dose Administration.

SOJ Pharm Pharm Sci.

2017 | journal-article

Flavonoids as potential reversing agents of the pharmacoresistance to antiepileptic drugs mediated by the P-glycoprotein

12th European Congress on Epileptology

2016 | conference-poster

Early results of next-gen cytogenetics implementation in Portugal

European Human Genetics Conference 2016

2016 | conference-paper

P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review.

Natural product communications

2016 | journal-article

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.

International journal of pharmaceutics

2016 | journal-article

Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.

Biomedical chromatography : BMC

2016 | journal-article

Pharmacokinetics of opicapone, a novel catechol-O-methyltransferase inhibitor, in the Wistar rat

Parkinsonism & Related Disorders

2016 | journal-article

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.

International Journal of Pharmaceutics.

2016 | journal-article

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

Current drug metabolism

2016 | journal-article

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

Curr Drug Metab.

2016 | journal-article

Huperzine A from Huperzia serrata: a review os its sources, chemistry, pharmacology and toxicology.

Phytochemistry Reviews.

2016 | journal-article

P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review

Natural product Communications

2016 | journal-article

Amikacin plasma monitoring in treating Portuguese patients infected with Acinetobacter baumannii

44th ESCP Symposium on Clinical Pharmacy Lisbon, Portugal

2015 | conference-poster

Phenytoin in pediatric patients: How important is the AEDs therapeutic drug monitoring?

44th ESCP Symposium on Clinical Pharmacy

2015 | conference-poster

2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development

Biomedical Chemistry

2015 | book-chapter

Development of a liquid chromatography assay for the determination of opicapone and BIA 9–1079 in rat matrices

Biomedical Chromatography

2015 | journal-article

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

International Journal of Pharmaceutics

2015 | journal-article

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

International Journal of Pharmaceutics

2015 | journal-article

Pharmacokinetics and Bioanalysis to Improve Drug Development: focus on pharmacokinetic studies

BIOMEDICAL CHEMISTRY - CURRENT TRENDS AND DEVELOPMENTS

2015 | book-chapter

Pharmacokinetics and bioanalysis to improve drug development

Biomedical Chemistry: Current Trends and Developments

2015 | book

The Pharmacology of Simvastatin: from the mechanism of action to new therapeuticapplications

SIMVASTATIN DELIVERY: CHALLENGES AND OPPORTUNITIES

2015 | book-chapter

The pharmacology of simvastatin: From the mechanism of action to new therapeutic applications

Simvastatin Delivery: Challenges and Opportunities

2015 | book

Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology

Phytochemistry Reviews

2014 | journal-article

Development of a new PAMPA method for the prediction of blood-brain barrier permeation using an in-house brain lipid extract

17th International Symposium on Signal Transduction at the Blood-Brain and Blood-Retina Barriers

2014 | conference-poster

Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting

European Journal of Pharmaceutical Sciences

2014 | journal-article

Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats

Journal of Pharmacy & Pharmaceutical Sciences

2014 | journal-article

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

Phytochemistry Reviews

2014 | journal-article

Avaliação do potencial da via intranasal para a administração de fármacos antiepiléticos: aplicação à carbamazepina

26º Encontro Nacional de Epileptologia

2014 | conference-poster

Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

Current Drug Safety

2014 | journal-article

A new MEPS/HPLC assay to quantify venlafaxine and its main metabolite in human plasma

43rd European Symposium on Clinical Pharmacy

2014 | conference-poster

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Chiral chromatographic resolution of antiepileptic drugs and their metabolites: A challenge from the optimization to the application

Biomedical Chromatography

2014 | journal-article

Direct nose-to-brain delivery of carbamazepine after intranasal administration to mice.

9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

2014 | conference-paper

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

Phytochemistry Reviews

2014 | journal-article

Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats.

Journal of Pharmacy and Pharmaceutical Sciences

2014 | journal-article

Identification of P-glycoprotein inhibitors in Caco 2 cells: An in vitro screening methodology

9th World Meeting on Pharmaceutics

2014 | conference-paper

Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting.

European Journal of Pharmaceutical Sciences

2014 | journal-article

Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules.

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V

2014 | journal-article

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2014 | journal-article

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine.

Journal of Chromatography B,

2014 | journal-article

Medication regimen complexity evaluation in a hypertensive Portuguese population

43rd European Symposium on Clinical Pharmacy

2014 | conference-poster

Third- and Fourth-generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

Current Drug Safety

2014 | journal-article

An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.

The Analyst

2013 | journal-article

A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis

Bioanalysis

2013 | journal-article

First HPLC-UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2013 | journal-article

First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2013 | journal-article

Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples - A review

Analytica Chimica Acta

2013 | journal-article

Nose as a Route for Drug Delivery

Nasal Physiology and Pathophysiology of Nasal Disorders

2013 | book-chapter

Nose as a route for drug delivery

NASAL PHYSIOLOGY AND PATHOPHYSIOLOGY OF NASAL DISORDERS

2013 | book-chapter

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

Epilepsy Research

2013 | journal-article

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.

Epilepsy Research.

2013 | journal-article

In vitro screening and in vivo preclinical models fo r pharmacokinetic evaluation of carbamazepine and derivatives

Conferência Centro de Estudos Farmacêuticos (CEF)

2012 | conference-poster

A new parallel artificial membrane permeability assay for estimation of intestinal absorption and protein binding in drug discovery programs

6th European Congress of Pharmacology, EPHAR 20 12

2012 | conference-poster

Development of an in vitro bidirectional transport model for prediction of human drug absorption and assessment of P-glycoprotein involvement in intestinal drug absorption.

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Fast HPLC-UV method for the simultaneous de termination of carbamazepine, lamotrigine, oxcarbazepine and phenytoin in mouse plasma, brain and liver tissues.

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Influence of plasma protein binding and efflux transport mediated by P-glycoprotein on the enantioselective biodisposition of eslicarbazepine and R-licarbazepine.

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Plasma and brain pharmacokinetic profiles of carbamazepine and nine derivatives after oral administration to mice: implications for selection of drug candidates.

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Quantification of ciprofloxacin in plasma and nasal mucosa matrices by high-performance liquid chromatography with fluorescence detection

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Avaliação farmacométrica in silico, in vitro e in viv o da carbamazepina e análogos estruturais.

24º Encontro Nacional de Epileptologia

2012 | conference-poster

A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain

Biomedical Chromatography

2012 | journal-article

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review

Analytical and Bioanalytical Chemistry

2012 | journal-article

Erratum: Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review (Analytical and Bioanalytical Chemistry DOI: 10.1007/s00216-011-5706-8)

Analytical and Bioanalytical Chemistry

2012 | journal-article

Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique

Epilepsia

2012 | journal-article

Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: Application to dibenz[b,f]azepine-5-carboxamide derivatives

Journal of Pharmaceutical Sciences

2012 | journal-article

Análise farmacométrica de derivados da carbamazepina: avaliação in vitro, in vivo e in silico das suas propriedades farmacológicas

Universidade de Coimbra

2011 | dissertation-thesis

A rapid and robust HPLC-UV method for simultaneous quantification of three generations of anti-epileptic drugs in human plasma: carbamazepine, oxcarbazepine and eslicarbazepine acetate.

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

Assessment of the involvement of P-glycoprotein in intestinal drug absorption during drug discovery

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

Determination of norfloxacin, ciprofloxacin and lemofloxacin in hum an plasma by a simple and rapid liquid chromatographic method.

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

Development of an enantioselective high performance liquid chromatography analysis of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain.

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

Predicting human drug absorption with Parallel Artificial Membrane Permeability Assay.

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites

Journal of Separation Science

2011 | journal-article

Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma

Biomedical Chromatography

2011 | journal-article

In Vitro?In Vivo Correlation (IVIVC): A Strategic Tool in Drug Development

Journal of Bioequivalence & Bioavailability

2011 | journal-article

Novel HPLC-UV method to monitor plasma concentrations of six antiepileptic drugs and three of their main metabolites in patients with epilepsy.

Conferência Ibero-America na de Faculdades de Farmácia

2011 | conference-poster

A rapid and sensitive high-performance liquid chromatographic method to quantify carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.

WorldPharma2010 – 16th IUPHAR World Congress on Basis and Clinical Pharmacology

2010 | conference-poster

BIOMEDICAL CHROMATOGRAPHY - Bioanalysis in drug discovery and development: focus on pharmacokinetic studies.

2010 | book-chapter

Binding of licarbazepine enantiomers to mouse and human plasma proteins

Biopharmaceutics and Drug Disposition

2010 | journal-article

Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies

Biomedical Chromatography

2010 | book

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

Analytical and Bioanalytical Chemistry

2010 | journal-article

Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites

Therapeutic Drug Monitoring

2010 | journal-article

Lack of interference of Carbamazepine and its metabolites in the enantioselective therapeutic drug monitoring of eslicarbazepine acetate

WorldPharma2010 – 16th I UPHAR World Congress on Basis and Clinical Pharmacology

2010 | conference-poster

Morphological evaluation of rat liver tissue after the subcutaneous injection of 1,2-dimethylhydrazine

WorldPharma2010 – 16th IUPHAR World Congress on Basis and Clinical Pharmacology

2010 | conference-poster

Kidney drug exposure after multiple-dose administration of S- and R-licarbazepine to mice

38th American College of Clinical Pharmacology Annual Meeting. San Antonio (Texas)/Estados Unidos da América,

2009 | conference-poster

Plasma-brain distribution of licarbazapine enantiomers in mice on steady-state conditions

38th American College of Clinical Pharmacology Annual Meeting

2009 | conference-poster

Human plasma protein binding of S- and R-licarbazepine

XVIII CONGRESO de la Asociación Latinoamericana de Farmacología; XXX Reunión Anual Socie dad de Farmacología de Chile; XXIII Sociedad Chilena de Ciencias Fisiológicas; III Congreso Iberoamericano de Farmacología.

2009 | conference-poster

Intranasal drug delivery: How, why and what for?

Journal of Pharmacy and Pharmaceutical Sciences

2009 | journal-article

Metabolism and liver pharmacokinetics of S- and R-licarbazepine in mice at the steady-state.

38th American College of Clinical Pharmacology Annual Meeting

2009 | conference-poster

Plasma-brain distribution of licarbazepine enantiomers in mice on steady-state conditions.

38th American College of Clinical Pharmacology Annual Meeting

2009 | conference-poster

Plasma protein binding of licarbazepine enantiomers in human and mouse species.

1st International Epilepsy Colloquium

2008 | conference-poster

Binding of licarbazepine enantiomers to human serum albumin and alpha-1-a cid glycoprotein.

XVIII CONGRESO de la Asociación Latinoamericana de Farmacología; XXX Reunión Anual Socie dad de Farmacología de Chile; XXIII Sociedad Chilena de Ciencias Fisiológicas; III Congreso Iberoamericano de Farmacología.

2008 | conference-poster

Warfarin binding to human plasma proteins

2008 | other

Enantioselective HPLC-UV Assay for Eslicarbazepine Acetate (BIA 2-093) and its metabolites determination in mice plasma and tissues: application to pharmacokinetic studies.

Pharmaceutical Sciences World Congress (PSWC) – 3rd World Congress of the Board of Pharmaceutical Sciences of FIP.

2007 | conference-poster

Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma

Biomedical Chromatography

2007 | journal-article

Lamotrigine in patients submitted to video-electroencephalographic monitoring : effect of co-medication in temporal and extratemporal epilepsy

1st International Epilepsy Colloquium.

2007 | conference-poster

The importance of permeability screening in drug discovery process: PAMPA, Caco-2 and rat everted gut assays

Current Topics in Pharmacology

2007 | journal-article

High-Performance Liquid Chromatography and its Impact in the Development of Chiral Drugs: a Review

Trends in Chromatography

| journal-article

Chronopharmacokinetics of the antidepressant paroxetine: An in vitro and in vivo approach

Neuropharmacology

2025 | journal-article

Population pharmacokinetics of levetiracetam in patients diagnosed with refractory epilepsy: A real‐world study

Epilepsia

2025 | journal-article

A new population pharmacokinetic model for dosing optimization of zonisamide in patients with refractory epilepsy

European Journal of Pharmaceutical Sciences

2025 | journal-article

Pharmacokinetics of Non-Psychotropic Phytocannabinoids

Pharmaceutics

2025 | journal-article

Therapeutic effect of cyclosporine A-loading TPGS micelles on a mouse model of LPS-induced neuroinflammation

European Journal of Pharmaceutical Sciences

2025 | journal-article

Sex-dependent cortical morphometric and neurophysiological alterations in a genetic mouse model of tuberous sclerosis complex 2

3rd Annual Meeting of Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT)

2024 | conference-poster

Are we better together? Addressing a combined treatment of pitavastatin and temozolomide for brain cancer

European Journal of Pharmacology

2024 | journal-article

Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

Biomedicine & Pharmacotherapy

2024 | journal-article

Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan

Biochemical Pharmacology

2024 | journal-article

Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for?

Ageing Research Reviews

2024 | journal-article

Drug–Cannabinoid Interactions in Selected Therapeutics for Symptoms Associated with Epilepsy, Autism Spectrum Disorder, Cancer, Multiple Sclerosis, and Pain

Pharmaceuticals

2024 | journal-article

Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences

Biochemical Pharmacology

2024 | journal-article

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Acta Pharmacologica Sinica

2024 | journal-article

Possible relationship between tryptophan metabolism, serotonergic function and E/I neurotransmitters in Tuberous Sclerosis Complex 2

EMIM 2024

2024 | conference-poster

Enhancing glioblastoma therapy through lipid nanoparticle-mediated drug and gene co-delivery

XVth SPLC-CRS Conference on Controlled Drug Delivery: "New Horizons in Drug Delivery"

2024 | conference-poster

Intranasal irbesartan reverts cognitive decline and activates the PI3K/AKT pathway in an LPS-induced neuroinflammation mice model

International Immunopharmacology

2024 | journal-article

Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression

European Journal of Pharmaceutics and Biopharmaceutics

2024 | journal-article

Cannabinoid Modulation of Monoamine Levels in Mouse Brain: Unveiling Neurochemical Dynamics through an Innovative High-performance Liquid Chromatography-Fluorescence Detection Bioanalysis

Journal of Analysis and Testing

2024 | journal-article

Development and validation of an HPLC-DAD method for the quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene in human plasma and mouse matrices

The Analyst

2024 | journal-article

Intranasal Administration of Irbesartan as a New Strategy for Addressing Neurodegeneration in a Neuroinflammation Mice Model: Pharmacokinetic and Efficacy Evaluation

Congresso do Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra

2024 | conference-poster

The blood brain barrier dysfunction in healthy aging and dementia: why, how, what for?

Ageing Research Reviews

2024 | journal-article

A new bioanalytical tool for neurotransmitter monitoring in central nervous system diseases

2nd Annual Meeting of CIBIT

2023 | conference-poster

Development of a Pharmacokinetic Model for Bayesian Individualization of Oral Levetiracetam in Refractory Epileptic Patients

2nd Annual Meeting of CIBIT

2023 | conference-poster

Negative correlation between cortical tryptophan metabolism and E/I balance in a genetic mouse model of autism spectrum disorders

2nd CIBIT Meeting

2023 | conference-poster

Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol

2023 | preprint

HPLC DAD technique for the quantification of cannabinoids in human plasma and mouse matrices

PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences

2023 | conference-poster

Unveiling the molecular mechanisms of pitavastatin induced glioblastoma death using proteomics

PharmahDay 2023 | Annual Meeting of PhD Students in Pharmaceutical Sciences

2023 | conference-poster

Precision Meets Affordability: A Highly Sensitive HPLC-FLD Technique for Accurate Pitavastatin Quantification in Human Plasma

2023 | conference-paper

Decoding the molecular mechanisms of pitavastatin induced glioblastoma death through proteomics

ESN-ISN Neurochemistry School 2023

2023 | conference-poster

Gender Differences During Unpredictable Chronic Mild Stress (UCMS) And Paroxetine Intranasal Administration To Mice

36th ECNP Congress

2023 | conference-poster

Otimização da Entrega de Fármacos com Transportadores Lipídicos Nanoestruturados no Glioblastoma

X Congresso Iberoamericano em Ciências Farmacêuticas

2023 | conference-paper

Ultra High Performance Liquid Chromatography Technique to support Pharmacokinetic Monitoring of Losartan, Irbesartan and Valsartan

X Congresso Iberoamericano de Ciências Farmacêuticas

2023 | conference-poster

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

International Journal of Molecular Sciences

2023 | journal-article

Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics

Journal of Pharmaceutical Investigation

2023 | journal-article

Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?

Ageing Research Reviews

2023 | journal-article

Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability

International Journal of Pharmaceutics

2023 | journal-article

Achieving accurate measurements without breaking the bank: A highly sensitive technique for pitavastatin quantification in human plasma

XXVIII Encontro nacional da Sociedade Portuguesa de Química

2023 | conference-poster

Angiotensin Receptor Blockers as an Alternative Strategy for Addressing Neurodegeneration in a LPS Mice Model

Alzheimer’s Association International Congress

2023 | conference-poster

Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy

Pharmaceutics

2023 | journal-article

Air-liquid interface (ALI) impact on different respiratory cell cultures

European Journal of Pharmaceutics and Biopharmaceutics

2023 | journal-article

High Performance Liquid Chromatography Technique for the Quantification of Cannabigerol, Cannabidiol, Cannabinol and Cannabichromene in human plasma and mice matrix

International Scientific Congress - Clearing the smoke¿.: the importance of the endocannabinoid system in health and disease

2023 | conference-poster

Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients

Antibiotics

2023 | journal-article

Drug and Gene Delivery in Glioblastoma: Friends or Foes?, Delivery of RNA Therapeutics

Delivery of RNA Therapeutics, Final DARTER Meeting

2023 | conference-poster

Physiologically-Based Pharmacokinetic Modeling to Support the Determination of Drug Product Bioequivalence

Time-Proof Perspectives on Bioequivalence

2023 | book-chapter

From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder

Biochemical Pharmacology

2022 | journal-article

Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients

Biomedicines

2022 | journal-article

The quest for better treatments: a novel drug delivery approach to glioblastoma

IX Iberian Meeting on Colloids and Interfaces

2022 | conference-poster

Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel

International Journal of Pharmaceutics

2022 | journal-article

Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model

Toxicology in Vitro

2022 | journal-article

Deciphering specific miRNAs in brain tumors: a 5-miRNA signature in glioblastoma

Molecular Genetics and Genomics

2022 | journal-article

Nose-to-brain delivery of perampanel using a non-toxic self-microemulsion drug delivery system.

52ª Reunião da Sociedade Portuguesa de Farmacologia, 40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia

2022 | conference-abstract

A Stepwise Framework for the Systematic Development of Lipid Nanoparticles

Biomolecules

2022 | journal-article

Optimizing nanostructured lipid carriers for the intra nasal administration of paroxetine and escitalopram in the treatment of depression

1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal

2022 | conference-poster

Nasal-PAMPA: a novel in vitro tool for prediction of intranasal drug permeability

Drug Delivery to the Lungs

2022 | conference-abstract

Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug

PBP World Meeting 2022

2022 | conference-poster

New HPLC technology for monitoring neurotransmitters in the brain: a pre-clinical approach for neurological disorders

ternational Multi-Brain Barcelona Congress - Healthy, Pathological and Artificial Brain

2022 | conference-poster

PCT/IB2022/052060 - SMALL MOLECULES FOR USE IN PREVENTING AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES

2022 | patent

PCT/IB2022/061847 - WO/2023/105415: INTRANASAL ADMINISTRATION FOR A SUSTAINED BRAIN DELIVERY OF HIGHLY PROTEIN-BOUND DRUGS

2022 | patent

Renin-angiotensin system acting drugs: a possible role in Alzheimer’s disease

International Multi-Brain Barcelona Congress - Healthy, Pathological and Artificial Brain

2022 | conference-poster

Taking the most out of lipids: A systematic design of lipid-based nanoparticles

1st Advances in Polymeric Micelles for Therapeutic Applications, Coimbra, Portugal

2022 | conference-poster

Therapeutic drug monitoring of clozapine on patients with refractory schizophrenia

ESCP 2021 Virtual Symposium- Clinical pharmacy

2021 | conference-poster

DIRECT ORAL ANTICOAGULANTS (DOACS) USE IN PATIENTS WITH CARDIAC IMPLANTABLE DEVICES AND NON-VALVULAR ATRIAL FIBRILLATION: IMPACT OF OFF-LABEL DOSE USE IN SAFETY AND EFFICACY OUTCOMES

ESCP 2021 Symposium: Clinical pharmacy, working collaboratively in mental health care

2021 | conference-poster

The impact of smoking habits and comedicated drugs on clozapine/norclozapine ratios

4º Encontro SPFCS

2021 | conference-poster

The essential oil from the fruits of Peucedanum oreoselinum (L.) Moench (Apiaceae) as a natural source of P-glycoprotein inhibitors

Journal of Herbal Medicine

2021 | journal-article

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review

Journal of Pharmaceutical Analysis

2021 | journal-article

Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach

Chemosensors

2021 | journal-article

Amorphous Solid Dispersions for Nasal Delivery: Development, Characterization and Performance Studies

RDD 2021

2021 | conference-poster

In vitro release methodologies for nasal powder testing

PBP World Meeting

2021 | conference-poster

HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring

Journal of Pharmaceutical and Biomedical Analysis

2021 | journal-article

Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications

Life Sciences

2021 | journal-article

Quantification of antiepileptic drugs in human saliva as a new tool of therapeutic monitoring.

33º Nacional Meeting of Epileptology

2021 | conference-poster

Quantificação de fármacos antiepiléticos em saliva humana como uma nova ferramenta de monitorização da terapêutica

 33º Encontro Nacional de Epileptologia

2021 | conference-poster

Is intranasal administration an opportunity for direct brain delivery of lacosamide?

European Journal of Pharmaceutical Sciences

2021 | journal-article

Nose-to-brain delivery of perampanel: a promising therapeutic approach for epilepsy

51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of the Clinical Pharmacology and 20th Meeting of the Toxicology

2021 | conference-abstract

A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration

International Journal of Pharmaceutics

2021 | journal-article

Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients

Journal of Chromatography B

2021 | journal-article

Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: impact of off-label dose use in safety and efficacy outcomes

2021 | other

Benchmarking of particle engineering technologies for nasal powder manufacture

DDL 2020

2020 | conference-poster

Cystic fibrosis: Physiopathology and the latest pharmacological treatments

Pharmacological Research

2020 | journal-article

Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders

Pharmacological Research

2020 | journal-article

Salting-out assisted liquid–liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices

Journal of Separation Science

2020 | journal-article

Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy

Pharmaceutics

2020 | journal-article

Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

British Journal of Pharmacology

2020 | journal-article

Designing Lipid Nanoparticles for Intranasal Delivery of Antidepressants.

Journal of Aerosol Medicine and Pulmonary Drug Delivery

2020 | conference-abstract

Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration

Pharmaceutical Research

2020 | journal-article

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

Current Pharmaceutical Design

2020 | journal-article

Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma

Journal of Pharmaceutical and Biomedical Analysis

2020 | journal-article

Impact of direct oral anticoagulant off‐label doses on clinical outcomes of atrial fibrillation patients: A systematic review

British Journal of Clinical Pharmacology

2020 | journal-article

Avaliação da adesão terapêutica em doentes com epilepsia medicados com levetiracetam recorrendo à monitorização farmacocinética

2020 | other

Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia

2020 | other

Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.

Drug Repurposing in Cancer Therapy: Approaches and Applications

2020 | book-chapter

Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development

Nanotherapy for Brain Tumor Drug Delivery

2020 | book-chapter

Establishing xenograft glioblastoma models for use in preclinical development

Nanotherapy for Brain Tumor Drug Delivery, Neuromethods Book Series

2020 | book-chapter

Nanotechnological approaches in cancer

Drug Repurposing in Cancer Therapy

2020 | book-chapter

Novel Routes to Accessing the Brain: Intranasal Administration

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

PCT/IB2020/061452 - WO/2021/111364A1 : Dual nanostructured lipid carrier as a multifunctional platform for brain tumor therapy

2020 | patent

QbD-driven development of intranasal lipid nanoparticles for depression treatment

European Journal of Pharmaceutics and Biopharmaceutics

2020 | journal-article

Understanding brain delivery

Nanoparticles for Brain Drug Delivery

2020 | book-chapter

How does the device determine nose-to-brain drug delivery to mice?

Drug Delivery to the Lungs (DDL 2019)

2019 | conference-poster

Nasal powder delivery: a step towards a biorelevant dissolution system

Drug Delivery to the Lungs (DDL2019)

2019 | conference-poster

Application of in vitro nasal model for antidepressant drug permeation studies

1st Annual Meeting in Pharmaceutical Sciences

2019 | conference-poster

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I

Pharmaceuticals

2019 | journal-article

Direct oral anticoagulants (DOACs) use in patients with cardiac implantable devices and non-valvular atrial fibrillation: the complexity of dose adjustments

48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)

2019 | conference-poster

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review

Analytica Chimica Acta

2019 | journal-article

Pharmacokinetic data model on assessing adherence to levetiracetam

48th Symposium of European Society of Clinical Pharmacy (ESCP 2019)

2019 | conference-poster

Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies

Journal of Chromatography B

2019 | journal-article

Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice

Biomedical Chromatography

2019 | journal-article

Development and validation of the first HPLC method for quantification of perampanel and stiripentol in mouse matrices using an innovator salting-out assisted liquid-liquid extraction procedure optimized by a design of experiments approach

53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI 2019)

2019 | conference-poster

Direct Oral Anticoagulants adjustment in patients with cardiac implantable devices and non-valvular Atrial Fibrillation: A single-centre retrospective study

53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)

2019 | conference-poster

Direct oral anticoagulants (DOACs) adjustment in patients with cardiac implantable devices and non-valvular atrial fibrillation, foccusing on renal adjustment: a single-centre retrospective study

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Nose-to-brain delivery of levetiracetam: preclinical evidence

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Therapeutic drug monitoring of levetiracetam: Pharmacokinetic characterization and compliance assessment of epileptic patients

53rd Annual Scientific Meeting of the European Society for Clinical Investigation

2019 | conference-poster

Nose-to-brain delivery of levetiracetam after intranasal administration to mice

International Journal of Pharmaceutics

2019 | journal-article

Posters

European Journal of Clinical Investigation

2019 | journal-article

Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics and clinical outcomes: GnG-PK/PD-AD study

Experimental and Clinical Psychopharmacology

2019 | journal-article

Silymarin as a Flavonoid-Type P-Glycoprotein Inhibitor with impact on the Pharmacokinetics of Carbamazepine, Oxcarbazepine and Phenytoin in Rats

Drug and Chemical Toxicology

2019 | journal-article

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

Pharmacological Research

2019 | journal-article

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges

Drug Discovery Today

2019 | journal-article

Caracterização do perfil farmacocinético do levetiracetam em doentes Portugueses com epilepsia

31º Encontro Nacional de Epileptologia

2019 | conference-poster

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

Journal of Pharmaceutical Analysis

2019 | journal-article

Development and validation of the first HPLC-DAD method for rufinamide quantification in mouse plasma and tissues with focus on future pharmacokinetic studies.

XLIX Reunião da Sociedade Portuguesa de Farmacologia

2019 | conference-abstract

First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study

The Analyst

2019 | journal-article

How does the device determine nose-to-brain drug delivery to mice?

Drug Delivery to the Lungs (DDL 2019)

2019 | conference-paper

Mechanism of Action and Toxicological Profile of Essential Oils in Foodstuff

Advances in Processing Technologies for Bio-based Nanosystems in Food

2019 | book-chapter

Real-World Clinical Characterization of Subjects With Depression Treated With Antidepressant Drugs Focused on (Non-)Genetic Factors, Pharmacokinetics, and Clinical Outcomes: GnG-PK/PD-AD Study

Experimental and Clinical Psychopharmacology

2019 | journal-article

Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles

International Journal of Pharmaceutics

2019 | journal-article

Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats

Drug and Chemical Toxicology

2019 | journal-article

Application of pharmacokinetic monitoring of amikacin in its pharmacological effects

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective

Current Drug Metabolism

2018 | journal-article

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.

Epilepsy Res.

2018 | journal-article

ADME-T and pharmacokinetic parameters of antitrypanosomal/antitumoral analogues of licarin A

41ª Reunião Anual da Sociedade Brasileira de Química

2018 | conference-poster

Desenvolvimento e validação de um método para quantificação simultânea de lacosamida, levetiracetam e zonisamida no plasma de doentes epiléticos

Encontro Nacional de Epileptologia

2018 | conference-poster

Desenvolvimento e validação de uma nova metodologia de quantificação simultânea da lacosamida, levetiracetam e zonisamida em plasma de doentes epilépticos

30º Encontro Nacional de Epileptologia

2018 | conference-poster

Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma.

Bioanalysis

2018 | journal-article

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2018 | journal-article

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.

Food research international.

2018 | journal-article

Development and validation of an HPLC-FLD technique for colistin quantification and its plasma monitoring in hospitalized patients

Analytical Methods

2018 | journal-article

Evaluation of the pharmacokinetics of amikacin in neutropenic cancer patients: influence of cancer pathology and chemotherapy

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Genetic characterization of the CYP2C9, CYP2C19, CYP2D6 isoenzymes and P-glycoprotein in Portuguese depressive patients

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy

Epilepsy Research

2018 | journal-article

Levetiracetam therapy individualization: predictive performance of three pharmacokinetic models

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Microextraction Techniques in LC-MS Bioanalysis

Sample Preparation in LC-MS Bioanalysis

2018 | book-chapter

Monitoring lacosamide, levetiracetam, zonisamide in plasma of epileptic patients: personalizing the pharmacotherapy of levetiracetam

47th ESPC Symposium on Clinical Pharmacy

2018 | conference-poster

Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-DAD: a tool to perform pharmacokinetic studies.

XIII Annual CICS-UBI Symposium 2018

2018 | conference-abstract

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors.

Drug metabolism and disposition: the biological fate of chemicals

2017 | journal-article

Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study.

Pharmaceutical research

2017 | journal-article

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

Neuropharmacology

2017 | journal-article

Potential of baicalein, (-)-epigallocatechin gallate, kaempferol, quercetin and silymarin and their dual combinations in reversing the P-glycoprotein-mediated antiepileptic drug resistance

32nd International Epilepsy Congress

2017 | conference-poster

Effects of the silymarin, a P-glycoprotein inhibitor, on the pharmacokinetics of oxcarbazepine and its active metabolite licarbazepine

II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications

2017 | conference-poster

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.

Toxicology and applied pharmacology

2017 | journal-article

Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2017 | journal-article

Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy

Bioequivalence & Bioavailability International Journal.

2017 | journal-article

Effect of Kidney Function on Amikacin Pharmacokinetics on Hospitalized Patients: Knowledge to Improve Therapy

Bioequivalence & Bioavailability International Journal

2017 | journal-article

Effect of kidney function on amikacin pharmacokinetics on hospitalized patients: a knowledge to improve therapy

2017 | other

Flavonoid compounds as reversing agents of the P-glycoproteinmediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs.

Food Research International.

2017 | magazine-article

High risk of drug-induced phenoconversion and antidepressantdrug interactions at pharmacokinetic level in a naturalistic clinical setting

2017 | other

Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats.

Food and Chemical Toxicology.

2017 | journal-article

Pharmacokinetics of Cymbopogon citratus Infusion in Rats after Single Oral Dose Administration.

SOJ Pharm Pharm Sci.

2017 | journal-article

Flavonoids as potential reversing agents of the pharmacoresistance to antiepileptic drugs mediated by the P-glycoprotein

12th European Congress on Epileptology

2016 | conference-poster

Early results of next-gen cytogenetics implementation in Portugal

European Human Genetics Conference 2016

2016 | conference-paper

P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review.

Natural product communications

2016 | journal-article

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.

International journal of pharmaceutics

2016 | journal-article

Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.

Biomedical chromatography : BMC

2016 | journal-article

Pharmacokinetics of opicapone, a novel catechol-O-methyltransferase inhibitor, in the Wistar rat

Parkinsonism & Related Disorders

2016 | journal-article

A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates.

International Journal of Pharmaceutics.

2016 | journal-article

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

Current drug metabolism

2016 | journal-article

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

Curr Drug Metab.

2016 | journal-article

Huperzine A from Huperzia serrata: a review os its sources, chemistry, pharmacology and toxicology.

Phytochemistry Reviews.

2016 | journal-article

P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review

Natural product Communications

2016 | journal-article

Amikacin plasma monitoring in treating Portuguese patients infected with Acinetobacter baumannii

44th ESCP Symposium on Clinical Pharmacy Lisbon, Portugal

2015 | conference-poster

Phenytoin in pediatric patients: How important is the AEDs therapeutic drug monitoring?

44th ESCP Symposium on Clinical Pharmacy

2015 | conference-poster

2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development

Biomedical Chemistry

2015 | book-chapter

Development of a liquid chromatography assay for the determination of opicapone and BIA 9–1079 in rat matrices

Biomedical Chromatography

2015 | journal-article

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

International Journal of Pharmaceutics

2015 | journal-article

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

International Journal of Pharmaceutics

2015 | journal-article

Pharmacokinetics and Bioanalysis to Improve Drug Development: focus on pharmacokinetic studies

BIOMEDICAL CHEMISTRY - CURRENT TRENDS AND DEVELOPMENTS

2015 | book-chapter

Pharmacokinetics and bioanalysis to improve drug development

Biomedical Chemistry: Current Trends and Developments

2015 | book

The Pharmacology of Simvastatin: from the mechanism of action to new therapeuticapplications

SIMVASTATIN DELIVERY: CHALLENGES AND OPPORTUNITIES

2015 | book-chapter

The pharmacology of simvastatin: From the mechanism of action to new therapeutic applications

Simvastatin Delivery: Challenges and Opportunities

2015 | book

Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology

Phytochemistry Reviews

2014 | journal-article

Development of a new PAMPA method for the prediction of blood-brain barrier permeation using an in-house brain lipid extract

17th International Symposium on Signal Transduction at the Blood-Brain and Blood-Retina Barriers

2014 | conference-poster

Intranasal administration of carbamazepine to mice: A direct delivery pathway for brain targeting

European Journal of Pharmaceutical Sciences

2014 | journal-article

Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats

Journal of Pharmacy & Pharmaceutical Sciences

2014 | journal-article

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

Phytochemistry Reviews

2014 | journal-article

Avaliação do potencial da via intranasal para a administração de fármacos antiepiléticos: aplicação à carbamazepina

26º Encontro Nacional de Epileptologia

2014 | conference-poster

Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

Current Drug Safety

2014 | journal-article

A new MEPS/HPLC assay to quantify venlafaxine and its main metabolite in human plasma

43rd European Symposium on Clinical Pharmacy

2014 | conference-poster

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Chiral chromatographic resolution of antiepileptic drugs and their metabolites: A challenge from the optimization to the application

Biomedical Chromatography

2014 | journal-article

Direct nose-to-brain delivery of carbamazepine after intranasal administration to mice.

9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

2014 | conference-paper

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

Phytochemistry Reviews

2014 | journal-article

Herb-drug Pharmacokinetic Interaction between Carica Papaya Extract and Amiodarone in Rats.

Journal of Pharmacy and Pharmaceutical Sciences

2014 | journal-article

Identification of P-glycoprotein inhibitors in Caco 2 cells: An in vitro screening methodology

9th World Meeting on Pharmaceutics

2014 | conference-paper

Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting.

European Journal of Pharmaceutical Sciences

2014 | journal-article

Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules.

European Journal of Pharmaceutics and Biopharmaceutics

2014 | journal-article

Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V

2014 | journal-article

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2014 | journal-article

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine.

Journal of Chromatography B,

2014 | journal-article

Medication regimen complexity evaluation in a hypertensive Portuguese population

43rd European Symposium on Clinical Pharmacy

2014 | conference-poster

Third- and Fourth-generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

Current Drug Safety

2014 | journal-article

An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.

The Analyst

2013 | journal-article

A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis

Bioanalysis

2013 | journal-article

First HPLC-UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2013 | journal-article

First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2013 | journal-article

Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples - A review

Analytica Chimica Acta

2013 | journal-article

Nose as a Route for Drug Delivery

Nasal Physiology and Pathophysiology of Nasal Disorders

2013 | book-chapter

Nose as a route for drug delivery

NASAL PHYSIOLOGY AND PATHOPHYSIOLOGY OF NASAL DISORDERS

2013 | book-chapter

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

Epilepsy Research

2013 | journal-article

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.

Epilepsy Research.

2013 | journal-article

In vitro screening and in vivo preclinical models fo r pharmacokinetic evaluation of carbamazepine and derivatives

Conferência Centro de Estudos Farmacêuticos (CEF)

2012 | conference-poster

A new parallel artificial membrane permeability assay for estimation of intestinal absorption and protein binding in drug discovery programs

6th European Congress of Pharmacology, EPHAR 20 12

2012 | conference-poster

Development of an in vitro bidirectional transport model for prediction of human drug absorption and assessment of P-glycoprotein involvement in intestinal drug absorption.

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Fast HPLC-UV method for the simultaneous de termination of carbamazepine, lamotrigine, oxcarbazepine and phenytoin in mouse plasma, brain and liver tissues.

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Influence of plasma protein binding and efflux transport mediated by P-glycoprotein on the enantioselective biodisposition of eslicarbazepine and R-licarbazepine.

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Plasma and brain pharmacokinetic profiles of carbamazepine and nine derivatives after oral administration to mice: implications for selection of drug candidates.

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Quantification of ciprofloxacin in plasma and nasal mucosa matrices by high-performance liquid chromatography with fluorescence detection

6th European Congress of Pharmacology, EPHAR

2012 | conference-poster

Avaliação farmacométrica in silico, in vitro e in viv o da carbamazepina e análogos estruturais.

24º Encontro Nacional de Epileptologia

2012 | conference-poster

A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain

Biomedical Chromatography

2012 | journal-article

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review

Analytical and Bioanalytical Chemistry

2012 | journal-article

Erratum: Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review (Analytical and Bioanalytical Chemistry DOI: 10.1007/s00216-011-5706-8)

Analytical and Bioanalytical Chemistry

2012 | journal-article

Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique

Epilepsia

2012 | journal-article

Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: Application to dibenz[b,f]azepine-5-carboxamide derivatives

Journal of Pharmaceutical Sciences

2012 | journal-article

Análise farmacométrica de derivados da carbamazepina: avaliação in vitro, in vivo e in silico das suas propriedades farmacológicas

Universidade de Coimbra

2011 | dissertation-thesis

A rapid and robust HPLC-UV method for simultaneous quantification of three generations of anti-epileptic drugs in human plasma: carbamazepine, oxcarbazepine and eslicarbazepine acetate.

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

Assessment of the involvement of P-glycoprotein in intestinal drug absorption during drug discovery

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

Determination of norfloxacin, ciprofloxacin and lemofloxacin in hum an plasma by a simple and rapid liquid chromatographic method.

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

Development of an enantioselective high performance liquid chromatography analysis of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain.

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

Predicting human drug absorption with Parallel Artificial Membrane Permeability Assay.

Conferência Ibero-Americana de Faculdades de Farmácia

2011 | conference-poster

A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5- carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites

Journal of Separation Science

2011 | journal-article

Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma

Biomedical Chromatography

2011 | journal-article

In Vitro?In Vivo Correlation (IVIVC): A Strategic Tool in Drug Development

Journal of Bioequivalence & Bioavailability

2011 | journal-article

Novel HPLC-UV method to monitor plasma concentrations of six antiepileptic drugs and three of their main metabolites in patients with epilepsy.

Conferência Ibero-America na de Faculdades de Farmácia

2011 | conference-poster

A rapid and sensitive high-performance liquid chromatographic method to quantify carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.

WorldPharma2010 – 16th IUPHAR World Congress on Basis and Clinical Pharmacology

2010 | conference-poster

BIOMEDICAL CHROMATOGRAPHY - Bioanalysis in drug discovery and development: focus on pharmacokinetic studies.

2010 | book-chapter

Binding of licarbazepine enantiomers to mouse and human plasma proteins

Biopharmaceutics and Drug Disposition

2010 | journal-article

Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies

Biomedical Chromatography

2010 | book

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

Analytical and Bioanalytical Chemistry

2010 | journal-article

Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites

Therapeutic Drug Monitoring

2010 | journal-article

Lack of interference of Carbamazepine and its metabolites in the enantioselective therapeutic drug monitoring of eslicarbazepine acetate

WorldPharma2010 – 16th I UPHAR World Congress on Basis and Clinical Pharmacology

2010 | conference-poster

Morphological evaluation of rat liver tissue after the subcutaneous injection of 1,2-dimethylhydrazine

WorldPharma2010 – 16th IUPHAR World Congress on Basis and Clinical Pharmacology

2010 | conference-poster

Kidney drug exposure after multiple-dose administration of S- and R-licarbazepine to mice

38th American College of Clinical Pharmacology Annual Meeting. San Antonio (Texas)/Estados Unidos da América,

2009 | conference-poster

Plasma-brain distribution of licarbazapine enantiomers in mice on steady-state conditions

38th American College of Clinical Pharmacology Annual Meeting

2009 | conference-poster

Human plasma protein binding of S- and R-licarbazepine

XVIII CONGRESO de la Asociación Latinoamericana de Farmacología; XXX Reunión Anual Socie dad de Farmacología de Chile; XXIII Sociedad Chilena de Ciencias Fisiológicas; III Congreso Iberoamericano de Farmacología.

2009 | conference-poster

Intranasal drug delivery: How, why and what for?

Journal of Pharmacy and Pharmaceutical Sciences

2009 | journal-article

Metabolism and liver pharmacokinetics of S- and R-licarbazepine in mice at the steady-state.

38th American College of Clinical Pharmacology Annual Meeting

2009 | conference-poster

Plasma-brain distribution of licarbazepine enantiomers in mice on steady-state conditions.

38th American College of Clinical Pharmacology Annual Meeting

2009 | conference-poster

Plasma protein binding of licarbazepine enantiomers in human and mouse species.

1st International Epilepsy Colloquium

2008 | conference-poster

Binding of licarbazepine enantiomers to human serum albumin and alpha-1-a cid glycoprotein.

XVIII CONGRESO de la Asociación Latinoamericana de Farmacología; XXX Reunión Anual Socie dad de Farmacología de Chile; XXIII Sociedad Chilena de Ciencias Fisiológicas; III Congreso Iberoamericano de Farmacología.

2008 | conference-poster

Warfarin binding to human plasma proteins

2008 | other

Enantioselective HPLC-UV Assay for Eslicarbazepine Acetate (BIA 2-093) and its metabolites determination in mice plasma and tissues: application to pharmacokinetic studies.

Pharmaceutical Sciences World Congress (PSWC) – 3rd World Congress of the Board of Pharmaceutical Sciences of FIP.

2007 | conference-poster

Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma

Biomedical Chromatography

2007 | journal-article

Lamotrigine in patients submitted to video-electroencephalographic monitoring : effect of co-medication in temporal and extratemporal epilepsy

1st International Epilepsy Colloquium.

2007 | conference-poster

The importance of permeability screening in drug discovery process: PAMPA, Caco-2 and rat everted gut assays

Current Topics in Pharmacology

2007 | journal-article

High-Performance Liquid Chromatography and its Impact in the Development of Chiral Drugs: a Review

Trends in Chromatography

| journal-article

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