Pharmacokinetics of Non-Psychotropic Phytocannabinoids

Pharmaceutics

2025 | journal-article

Unveiling the potential of copper-61 vs. gallium-68 for SSTR PET imaging

European Journal of Nuclear Medicine and Molecular Imaging

2025 | journal-article

Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression

European Journal of Pharmaceutics and Biopharmaceutics

2024 | journal-article

A Novel Bionebulizer Approach to Study the Effects of Natural Mineral Water on a 3D In Vitro Nasal Model from Allergic Rhinitis Patients

Biomedicines

2024 | journal-article

A Review of Natural Polysaccharides: Sources, Characteristics, Properties, Food, and Pharmaceutical Applications

International Journal of Molecular Sciences

2024 | journal-article

A physiological approach to renal clearance: From premature neonates to adults

British Journal of Clinical Pharmacology

2024 | journal-article

Antioxidant activity of the main phenolics found in red fruits: An in vitro and in silico study

Food Chemistry

2024 | journal-article

Differential response of blueberry to the application of bacterial inoculants to improve yield, organoleptic qualities and concentration of bioactive compounds

Microbiological Research

2024 | journal-article

The Effect of Phenolic-Rich Extracts of Rubus fruticosus, R. ulmifolius and Morus nigra on Oxidative Stress and Caco-2 Inhibition Growth

Nutrients

2024 | journal-article

Patients’ Characterization, Pattern of Medication Use, and Factors Associated with Polypharmacy: A Cross-Sectional Study Focused on Eight Units of the Portuguese National Network for Long-Term Integrated Care

Healthcare

2023 | journal-article

Diversity of Culture Microorganisms from Portuguese Sweet Cherries

Life

2023 | journal-article

Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy

Pharmaceutics

2023 | journal-article

Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target Approach

Molecules

2023 | journal-article

Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting

Pharmaceutics

2023 | journal-article

Exploring the Antioxidant, Antidiabetic, and Antimicrobial Capacity of Phenolics from Blueberries and Sweet Cherries

Applied Sciences

2023 | journal-article

Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients

Antibiotics

2023 | journal-article

Artificial Dendritic Cells: A New Era of Promising Antitumor Immunotherapy

Small

2023 | journal-article

Blackberries and Mulberries: Berries with Significant Health-Promoting Properties

International Journal of Molecular Sciences

2023 | journal-article

Fighting Epilepsy with Nanomedicines-Is This the Right Weapon?

Pharmaceutics

2023 | journal-article

Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity

Pharmaceutics

2023 | journal-article

Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications

Pharmaceuticals

2023 | journal-article

Nose-to-brain delivery of perampanel formulated in a self-microemulsifying drug delivery system improves anticonvulsant and anxiolytic activity in mice

International Journal of Pharmaceutics

2023 | journal-article

Synthesis, In Vitro Biological Evaluation of Antiproliferative and Neuroprotective Effects and In Silico Studies of Novel 16E-Arylidene-5 alpha,6 alpha-epoxyepiandrosterone Derivatives

Biomedicines

2023 | journal-article

Under the umbrella of depression and Alzheimer's disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?

Ageing Research Reviews

2023 | journal-article

Anti-Inflammatory and Antimicrobial Activities of Portuguese Prunus avium L. (Sweet Cherry) By-Products Extracts

Nutrients

2022 | journal-article

Employ of Anthocyanins in Nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

Pharmaceutics

2022 | journal-article

Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

2022 | preprint

Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients

Biomedicines

2022 | journal-article

Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration

Pharmaceutics

2022 | journal-article

Effects of Functional Phenolics Dietary Supplementation on Athletes’ Performance and Recovery: A Review

International Journal of Molecular Sciences

2022 | journal-article

C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies

Applied Sciences

2022 | journal-article

Mineral Content and Volatile Profiling of Prunus avium L. (Sweet Cherry) By-Products from Fundão Region (Portugal)

Foods

2022 | journal-article

Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts

Molecules

2022 | journal-article

10 beta-Hydroxyestra-1,4-diene-3,17-dione as potential antiproliferative agent: in vitro biological evaluation and in silico studies

Natural Product Research

2022 | journal-article

⁸⁹Zr-immuno-PET imaging: from liquid target production to imaging

Nuclear Medicine and Biology

2022 | journal-article

Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties

Molecules

2022 | journal-article

Editorial: Intranasal Delivery of Central Nervous System Active Drugs: Opportunities and Challenges

Frontiers in Pharmacology

2022 | journal-article

Employ of Anthocyanins in Nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

Preprints.org

2022 | journal-article

Essential and non-essential elements, and volatile organic compounds for the discrimination of twenty-three sweet cherry cultivars from Fundao, Portugal

Food Chemistry

2022 | journal-article

Evaluation of Raw Cheese as a Novel Source of Biofertilizer with a High Level of Biosecurity for Blueberry

Agronomy

2022 | journal-article

Health Benefits of Prunus avium Plant Parts: An Unexplored Source Rich in Phenolic Compounds

Food Reviews International

2022 | journal-article

Insight into the Taxonomic and Functional Diversity of Bacterial Communities Inhabiting Blueberries in Portugal

Microorganisms

2022 | journal-article

Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel

International Journal of Pharmaceutics

2022 | journal-article

Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies

Molecules

2022 | journal-article

Safety of Non-Steroidal Anti-Inflammatory Drugs in the Elderly: An Analysis of Published Literature and Reports Sent to the Portuguese Pharmacovigilance System

International Journal of Environmental Research and Public Health

2022 | journal-article

Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs

Pharmaceutics

2022 | journal-article

Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model

Toxicology in Vitro

2022 | journal-article

Sweet cherry phenolics revealed to be promising agents in inhibiting P-glycoprotein activity and increasing cellular viability under oxidative stress conditions: in vitro and in silico study

Journal of Food Science

2022 | journal-article

Zimbro (Juniperus communis L.) as a Promising Source of Bioactive Compounds and Biomedical Activities: A Review on Recent Trends

International Journal of Molecular Sciences

2022 | journal-article

Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts

2021 | preprint

Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression

Pharmaceutics

2021 | journal-article

Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)

Foods

2021 | journal-article

Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies

International Journal of Molecular Sciences

2021 | journal-article

Prunus avium L. (Sweet Cherry) By-Products: A Source of Phenolic Compounds with Antioxidant and Anti-Hyperglycemic Properties—A Review

Applied Sciences

2021 | journal-article

Valorisation of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability

Foods

2021 | journal-article

New Estrone Oxime Derivatives: Synthesis, Cytotoxic Evaluation and Docking Studies

Molecules

2021 | journal-article

A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration

International Journal of Pharmaceutics

2021 | journal-article

Adverse drug reactions in elderly: a five-year review of spontaneous reports to the Portuguese pharmacovigilance system

Expert Opinion on Drug Safety

2021 | journal-article

Assessment of suspected adverse drug reactions in elderly patients with diabetes mellitus based on a Portuguese spontaneous reporting database: analysis of reporting from 2008 to 2018

Expert Opinion on Drug Safety

2021 | journal-article

Consumption of Phenolic-Rich Food and Dietary Supplements as a Key Tool in SARS-CoV-19 Infection

Foods

2021 | journal-article

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

Pharmaceuticals

2021 | journal-article

Dietary use of Rosmarinus officinalis and Thymus vulgaris as anticoccidial alternatives in poultry

Animal Feed Science and Technology

2021 | journal-article

Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation

Frontiers in Pharmacology

2021 | journal-article

Highlights on Steroidal Arylidene Derivatives as a Source of Pharmacologically Active Compounds: A Review

Molecules

2021 | journal-article

Intranasal fosphenytoin: The promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs

International Journal of Pharmaceutics

2021 | journal-article

Is intranasal administration an opportunity for direct brain delivery of lacosamide?

European Journal of Pharmaceutical Sciences

2021 | journal-article

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review

Journal of Pharmaceutical Analysis

2021 | journal-article

Methods to improve the immunogenicity of plasmid DNA vaccines

Drug Discovery Today

2021 | journal-article

Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion-formulation development and in vivo pharmacokinetics

European Journal of Pharmaceutical Sciences

2021 | journal-article

Pharmacists' Role in Older Adults' Medication Regimen Complexity: A Systematic Review

International Journal of Environmental Research and Public Health

2021 | journal-article

Physical and phytochemical composition of 23 Portuguese sweet cherries as conditioned by variety (or genotype)

Food Chemistry

2021 | journal-article

Potential Activity of Abrantes Pollen Extract: Biochemical and Cellular Model Studies

Foods

2021 | journal-article

Potentially Inappropriate Medications and Potential Prescribing Omissions in Elderly Patients Receiving Post-Acute and Long-Term Care: Application of Screening Tool of Older People's Prescriptions/Screening Tool to Alert to Right Treatment Criteria

Frontiers in Pharmacology

2021 | journal-article

Serotonin and Melatonin: Plant Sources, Analytical Methods, and Human Health Benefits

Revista Brasileira de Farmacognosia

2021 | journal-article

Cystic fibrosis: Physiopathology and the latest pharmacological treatments

Pharmacological Research

2020 | journal-article

Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy

Pharmaceutics

2020 | journal-article

Clinical pharmacists´ interventions in the management of type 2 diabetes mellitus: a systematic review

Pharmacy Practice

2020 | journal-article

Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics

British Journal of Pharmacology

2020 | journal-article

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

Current Pharmaceutical Design

2020 | journal-article

Authentication of honeys from Caramulo region (Portugal): Pollen spectrum, physicochemical characteristics, mineral content, and phenolic profile

Journal of Food Science

2020 | journal-article

Characterization of a Parkinson's disease rat model using an upgraded paraquat exposure paradigm

European Journal of Neuroscience

2020 | journal-article

Delta(9,11)-Estrone derivatives as potential antiproliferative agents: synthesis, in vitro biological evaluation and docking studies

Comptes Rendus Chimie

2020 | journal-article

Dendritic cell vaccines for cancer immunotherapy: The role of human conventional type 1 dendritic cells

Pharmaceutics

2020 | journal-article

Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma

Journal of Pharmaceutical and Biomedical Analysis

2020 | journal-article

Efficacy and safety of eslicarbazepine acetate as adjunctive therapy for refractory focal-onset seizures in children: A double-blind, randomized, placebo-controlled, parallel-group, multicenter, phase-III clinical trial

Epilepsy and Behavior

2020 | journal-article

HOW DOES THE DEVICE DETERMINE NOSE-TO-BRAIN DRUG DELIVERY TO MICE?

Journal of Aerosol Medicine and Pulmonary Drug Delivery

2020 | journal-article

Medication Evaluation in Portuguese Elderly Patients According to Beers, STOPP/START Criteria and EU(7)-PIM List - An Exploratory Study

Patient Preference and Adherence

2020 | journal-article

Multitarget protection of Pterospartum tridentatum phenolic-rich extracts against a wide range of free radical species, antidiabetic activity and effects on human colon carcinoma (Caco-2) cells

Journal of Food Science

2020 | journal-article

Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration

Pharmaceutical Research

2020 | journal-article

Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders

Pharmacological Research

2020 | journal-article

Salting-out assisted liquid-liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices

Journal of Separation Science

2020 | journal-article

Thymus mastichina: Composition and Biological Properties with a Focus on Antimicrobial Activity

Pharmaceuticals

2020 | journal-article

Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients

BMC Anesthesiology

2019 | journal-article

Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review

Analytica Chimica Acta

2019 | journal-article

Nose-to-brain delivery of levetiracetam after intranasal administration to mice

International Journal of Pharmaceutics

2019 | journal-article

ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches

Pharmacological Research

2019 | journal-article

Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges

Drug Discovery Today

2019 | journal-article

Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy

Journal for ImmunoTherapy of Cancer

2019 | journal-article

Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices

Journal of Pharmaceutical Analysis

2019 | journal-article

Effectiveness of an intervention to improve antibiotic-prescribing behaviour in primary care: A controlled, interrupted time-series study

Journal of Antimicrobial Chemotherapy

2019 | journal-article

First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats – a pharmacokinetics study

The Analyst

2019 | journal-article

Larger dose reductions of vancomycin required in neonates with patent ductus arteriosus receiving indomethacin versus ibuprofen

Antimicrobial Agents and Chemotherapy

2019 | journal-article

Microextraction Techniques in LC-MS Bioanalysis

Sample Preparation in Lc-ms Bioanalysis

2019 | journal-article

Novel bioanalytical method for the quantification of rufinamide in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2019 | journal-article

Pharmacogenetics and Therapeutic Drug Monitoring of Fluoxetine in a Real-World Setting: A PK/PD Analysis of the Influence of (Non-)Genetic Factors

Experimental and Clinical Psychopharmacology

2019 | journal-article

Population Pharmacokinetic-Pharmacodynamic Modeling for Propofol Anesthesia Guided by the Bispectral Index (BIS)

Journal of Clinical Pharmacology

2019 | journal-article

Real-World Clinical Characterization of Subjects With Depression Treated With Antidepressant Drugs Focused on (Non-)Genetic Factors, Pharmacokinetics, and Clinical Outcomes: GnG-PK/PD-AD Study

Experimental and Clinical Psychopharmacology

2019 | journal-article

Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles

International Journal of Pharmaceutics

2019 | journal-article

Short-term effects of Garcinia cambogia extract on the pharmacokinetics of lamotrigine given as a single-dose in Wistar rats

Food and Chemical Toxicology

2019 | journal-article

Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats

Drug and Chemical Toxicology

2019 | journal-article

Sweet Cherry Phenolic Compounds: Identification, Characterization, and Health Benefits

Studies in Natural Products Chemistry

2019 | journal-article

Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3,4-dihydropyrimidin-2-(1H)-thiones

Arabian Journal of Chemistry

2019 | journal-article

In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy

Epilepsy Research

2018 | journal-article

Considerations and pitfalls in selecting the drug vehicles for evaluation of new drug candidates: Focus on in vivo pharmaco-toxicological assays based on the rotarod performance test

Journal of Pharmacy and Pharmaceutical Sciences

2018 | journal-article

Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma

Bioanalysis

2018 | journal-article

Development and validation of an HPLC-FLD technique for colistin quantification and its plasma monitoring in hospitalized patients

Analytical Methods

2018 | journal-article

Effects of Paullinia cupana extract on lamotrigine pharmacokinetics in rats: A herb-drug interaction on the gastrointestinal tract with potential clinical impact

Food and Chemical Toxicology

2018 | journal-article

Evaluation of the effects of Citrus aurantium (bitter orange) extract on lamotrigine pharmacokinetics: Insights from in vivo studies in rats

Food and Chemical Toxicology

2018 | journal-article

Exposure-safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate

Acta Neurologica Scandinavica

2018 | journal-article

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs

Food Research International

2018 | journal-article

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein

European Journal of Pharmaceutical Sciences

2018 | journal-article

Relevance of breast cancer resistance protein to brain distribution and central acting drugs: A pharmacokinetic perspective

Current Drug Metabolism

2018 | journal-article

Safety evidence on the administration of Fucus vesiculosus L. (bladderwrack) extract and lamotrigine: data from pharmacokinetic studies in the rat

Drug and Chemical Toxicology

2018 | journal-article

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat

Neuropharmacology

2017 | journal-article

Calprotectin and the Magnitude of Antibodies to Infliximab in Clinically-stable Ulcerative Colitis Patients are More Relevant Than Infliximab Trough Levels and Pharmacokinetics for Therapeutic Escalation

EBioMedicine

2017 | journal-article

Dendritic cell-based immunotherapy: a basic review and recent advances

Immunologic research

2017 | journal-article

Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native fluorescence and liquid chromatography

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2017 | journal-article

Determination of lamotrigine in human plasma and saliva using microextraction by packed sorbent and high performance liquid chromatography–diode array detection: An innovative bioanalytical tool for therapeutic drug monitoring

Microchemical Journal

2017 | journal-article

Early preclinical evaluation of dihydropyrimidin(thi)ones as potential anticonvulsant drug candidates

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics

British journal of clinical pharmacology

2017 | journal-article

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors

Drug metabolism and disposition: the biological fate of chemicals

2017 | journal-article

In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2017 | journal-article

Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2017 | journal-article

Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study

Pharmaceutical research

2017 | journal-article

Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

On ciprofloxacin concentration in chronic rhinosinusitis

Acta otorrinolaringologica espanola

2017 | journal-article

Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat

Toxicology and applied pharmacology

2017 | journal-article

Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders

Mini reviews in medicinal chemistry

2017 | journal-article

Reliability of body-weight scalars on the assessment of propofol induction dose in obese patients

Acta anaesthesiologica Scandinavica

2017 | journal-article

Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2017 | journal-article

Steroidal oximes: useful compounds with antitumor activities

Current medicinal chemistry

2017 | journal-article

Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction by Packed Sorbent Coupled to Liquid Chromatography

Journal of analytical toxicology

2017 | journal-article

A new PAMPA model using an in-house brain lipid extract for screening the blood–brain barrier permeability of drug candidates

International Journal of Pharmaceutics

2016 | journal-article

A Rapid and Sensitive HPLC-DAD Assay to Quantify Lamotrigine, Phenytoin and Its Main Metabolite in Samples of Cultured HepaRG Cells

Journal of chromatographic science

2016 | journal-article

An easy-to-use liquid chromatography assay for the analysis of lamotrigine in rat plasma and brain samples using microextraction by packed sorbent: Application to a pharmacokinetic study

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2016 | journal-article

Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction Studies?

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2016 | journal-article

Can the CEIBA cocktail designed for human cytochrome P450 enzymes be used in the rat for drug interaction studies?

Journal of Pharmacy and Pharmaceutical Sciences

2016 | journal-article

Determinants of physician antibiotic prescribing behavior: A 3 year cohort study in Portugal

Current Medical Research and Opinion

2016 | journal-article

Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method

European Journal of Pharmaceutical Sciences

2016 | journal-article

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs

Current drug metabolism

2016 | journal-article

Gastrodia elata and epilepsy: Rationale and therapeutic potential

Phytomedicine : international journal of phytotherapy and phytopharmacology

2016 | journal-article

HPLC–DAD Method for the Quantification of Carbamazepine, Oxcarbazepine and their Active Metabolites in HepaRG Cell Culture Samples

Chromatographia

2016 | journal-article

Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology

Phytochemistry Reviews

2016 | journal-article

Pharmacist Interventions in the Management of Type 2 Diabetes Mellitus: A Systematic Review of Randomized Controlled Trials

Journal of managed care & specialty pharmacy

2016 | journal-article

Physicians' attitudes and knowledge concerning antibiotic prescription and resistance: Questionnaire development and reliability

BMC Infectious Diseases

2016 | journal-article

Potential antitumoral 3,4-dihydropyrimidin-2-(1: H)-ones: synthesis, in vitro biological evaluation and QSAR studies

RSC Advances

2016 | journal-article

Treatment with subcutaneous and transdermal fentanyl: Results from a population pharmacokinetic study in cancer patients

European Journal of Clinical Pharmacology

2016 | journal-article

Antitumor dendritic cell-based vaccines: lessons from 20 years of clinical trials and future perspectives.

2015 | journal-article

Effect of three single-dose regimens of opicapone on levodopa pharmacokinetics, catechol- O -methyltransferase activity and motor response in patients with Parkinson's disease

Clinical Pharmacology in Drug Development

2015 | journal-article

Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.

2015 | journal-article

Opicapone pharmacokinetics and pharmacodynamics comparison between healthy Japanese and matched Caucasian subjects

Clinical Pharmacology in Drug Development

2015 | journal-article

A new MEPS/HPLC assay to quantify venlafaxine and its main metabolite in human plasma

International Journal of Clinical Pharmacy

2015 | journal-article

Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I

Journal of affective disorders

2015 | journal-article

Cardiac safety profile of etamicastat, a novel peripheral selective dopamine-β-hydroxylase inhibitor in non-human primates, human young and elderly healthy volunteers and hypertensive patients

IJC Metabolic and Endocrine

2015 | journal-article

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

International journal of pharmaceutics

2015 | journal-article

Effect of opicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity and motor fluctuations in patients with Parkinson's disease

European journal of neurology

2015 | journal-article

Evaluation of opicapone on cardiac repolarization in a thorough QT/QTc study

Clinical Pharmacology in Drug Development

2015 | journal-article

Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology

Phytochemistry Reviews

2015 | journal-article

Medication regimen complexity evaluation in a hypertensive portuguese population

International Journal of Clinical Pharmacy

2015 | journal-article

Pharmacokinetics and bioanalysis to improve drug development

Biomedical Chemistry: Current Trends and Developments

2015 | book-chapter

The pharmacology of simvastatin: From the mechanism of action to new therapeutic applications

Simvastatin Delivery: Challenges and Opportunities

2015 | book

Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: Experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I.

2014 | journal-article

Use of off-label and unlicenced drugs in hospitalised paediatric patients: a systematic review.

2014 | journal-article

Clinical drug-drug interactions: focus on venlafaxine.

2014 | journal-article

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2014 | journal-article

Chiral chromatographic resolution of antiepileptic drugs and their metabolites: a challenge from the optimization to the application

Biomedical chromatography : BMC

2014 | journal-article

Effect of moderate liver impairment on the pharmacokinetics of opicapone

European journal of clinical pharmacology

2014 | journal-article

Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations

European journal of clinical pharmacology

2014 | journal-article

First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma

Bioanalysis

2014 | journal-article

HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction: amiodarone used as a model substance

Toxicology in vitro : an international journal published in association with BIBRA

2014 | journal-article

Herb-drug pharmacokinetic interaction between carica papaya extract and amiodarone in rats

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2014 | journal-article

Herb-drug pharmacokinetic interaction between carica papaya extract and amiodarone in rats

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2014 | journal-article

Herb-drug pharmacokinetic interaction between carica papaya extract and amiodarone in rats

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2014 | journal-article

Herb-drug pharmacokinetic interaction between carica papaya extract and amiodarone in rats

Journal of Pharmacy and Pharmaceutical Sciences

2014 | journal-article

Herb-drug pharmacokinetic interaction between carica papaya extract and amiodarone in rats.

2014 | journal-article

Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2014 | journal-article

Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2014 | journal-article

Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2014 | journal-article

Third and fourth generation fluoroquinolone antibacterials: A systematic review of safety and toxicity profiles

Current Drug Safety

2014 | journal-article

Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles

Current drug safety

2014 | journal-article

Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles.

2014 | journal-article

Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers

Drug metabolism and drug interactions

2014 | journal-article

A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis

Bioanalysis

2013 | journal-article

A rapid HPLC method for the simultaneous determination of amiodarone and its major metabolite in rat plasma and tissues: a useful tool for pharmacokinetic studies

Journal of chromatographic science

2013 | journal-article

Aflatoxin M1 in marketed milk in Portugal: Assessment of human and animal exposure

Food Control

2013 | journal-article

An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma

The Analyst

2013 | journal-article

Bioequivalence of eslicarbazepine acetate from two different sources of its active product ingredient in healthy subjects

Drugs in R&D

2013 | journal-article

Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral contraceptive in healthy women

Epilepsy research

2013 | journal-article

Effect of repeated administration of eslicarbazepine acetate on the pharmacokinetics of simvastatin in healthy subjects

Epilepsy research

2013 | journal-article

Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: integrated analysis of pooled data from double-blind phase III clinical studies

Epilepsia

2013 | journal-article

First HPLC-UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine, carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2013 | journal-article

First liquid chromatographic method for the simultaneous determination of amiodarone and desethylamiodarone in human plasma using microextraction by packed sorbent (MEPS) as sample preparation procedure

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2013 | journal-article

First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2013 | journal-article

Herb-drug interaction of Fucus vesiculosus extract and amiodarone in rats: a potential risk for reduced bioavailability of amiodarone in clinical practice

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2013 | journal-article

Investigating herb-drug interactions: the effect of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2013 | journal-article

Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples--a review

Analytica chimica acta

2013 | journal-article

Long-term safety and efficacy of eslicarbazepine acetate as adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy: results of a 1-year open-label extension study

Epilepsy research

2013 | journal-article

Nose as a route for drug delivery

Nasal Physiology and Pathophysiology of Nasal Disorders

2013 | book

Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

British journal of clinical pharmacology

2013 | journal-article

Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers

Epilepsia

2013 | journal-article

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models

Epilepsy research

2013 | journal-article

Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor

Clinical pharmacokinetics

2013 | journal-article

Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers

Epilepsia

2013 | journal-article

Understanding physician antibiotic prescribing behaviour: a systematic review of qualitative studies

International journal of antimicrobial agents

2013 | journal-article

Workshop- and telephone-based interventions to improve adverse drug reaction reporting: a cluster-randomized trial in Portugal.

2012 | journal-article

A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain

Biomedical chromatography : BMC

2012 | journal-article

Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: a review

Analytical and bioanalytical chemistry

2012 | journal-article

Bioanalysis of small-molecule drugs in nasal and paranasal tissues and secretions: Current status and perspectives

Central European Journal of Chemistry

2012 | journal-article

Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review

Analytica chimica acta

2012 | journal-article

Erratum: Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations by liquid chromatography: A review (Analytical and Bioanalytical Chemistry DOI: 10.1007/s00216-011-5706-8)

Analytical and Bioanalytical Chemistry

2012 | journal-article

Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique

Epilepsia

2012 | journal-article

Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats

Evidence-based Complementary and Alternative Medicine : eCAM

2012 | journal-article

Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz[b,f]azepine-5-carboxamide derivatives

Journal of pharmaceutical sciences

2012 | journal-article

Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analyses

CNS drugs

2012 | journal-article

Single-dose tolerability, pharmacokinetics, and pharmacodynamics of etamicastat (BIA 5-453), a new dopamine β-hydroxylase inhibitor, in healthy subjects

Journal of clinical pharmacology

2012 | journal-article

Workshop- and telephone-based interventions to improve adverse drug reaction reporting: a cluster-randomized trial in Portugal

Drug safety

2012 | journal-article

A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5-carboxamide derivatives in mouse plasma and brain tissue: eslicarbazepine acetate, carbamazepine and main metabolites

Journal of separation science

2011 | journal-article

Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies

Drug Policies, Addiction and Eradication

2011 | book

Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma

Biomedical chromatography : BMC

2011 | journal-article

Effect of food on the pharmacokinetic profile of etamicastat (BIA 5-453)

Drugs in R&D

2011 | journal-article

In vitro and In vivo Relevance of the P-glycoprotein Probe Substrates in Drug Discovery and Development: Focus on Rhodamine 123, Digoxin and Talinolol

JBB

2011 | journal-article

In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs

The Journal of pharmacy and pharmacology

2011 | journal-article

Pharmacokinetics and tolerability of etamicastat following single and repeated administration in elderly versus young healthy male subjects: an open-label, single-center, parallel-group study

Clinical therapeutics

2011 | journal-article

Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures

Epilepsy research

2011 | journal-article

Binding of licarbazepine enantiomers to mouse and human plasma proteins

Biopharmaceutics & drug disposition

2010 | journal-article

Bioanalysis in drug discovery and development: Focus on pharmacokinetic studies

Biomedical Chromatography

2010 | book-chapter

Chronopharmacology of nebicapone, a new catechol-O-methyltransferase inhibitor

Current medical research and opinion

2010 | journal-article

Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

Analytical and bioanalytical chemistry

2010 | journal-article

Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study

Clinical therapeutics

2010 | journal-article

Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study.

Clinical therapeutics

2010 | journal-article

Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine and its metabolites

Therapeutic drug monitoring

2010 | journal-article

Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects

Acta neurologica Scandinavica

2010 | journal-article

Pharmacokinetic interaction study between eslicarbazepine acetate and topiramate in healthy subjects

Current medical research and opinion

2010 | journal-article

Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-β-hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects

Drugs in R&D

2010 | journal-article

Usefulness of factor II and factor X as therapeutic markers in patients under chronic warfarin therapy

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2010 | journal-article

Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects.

2009 | journal-article

Antibiotics in Animal Products

Predictive Modeling and RiskAssessment

2009 | other

Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects

Fundamental & clinical pharmacology

2009 | journal-article

Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects

International journal of clinical pharmacology and therapeutics

2009 | journal-article

Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects

International Journal of Clinical Pharmacology and Therapeutics

2009 | journal-article

Intranasal drug delivery: How, why and what for?

Journal of Pharmacy and Pharmaceutical Sciences

2009 | journal-article

Intranasal drug delivery: how, why and what for?

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2009 | journal-article

Intranasal drug delivery: how, why and what for?

2009 | journal-article

KIDNEY DRUG EXPOSURE AFTER MULTIPLE-DOSE ADMINISTRATION OF S- AND R-LICARBAZEPINE TO MICE

The Journal of Clinical Pharmacology

2009 | journal-article

METABOLISM AND LIVER PHARMACOKINETICS OF S- AND R-LICARBAZEPINE IN MICE AT THE STEADY-STATE

The Journal of Clinical Pharmacology

2009 | journal-article

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

Molecular nutrition & food research

2009 | journal-article

Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects

Clinical therapeutics

2009 | journal-article

Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and young subjects

Journal of clinical pharmacology

2009 | journal-article

The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drugs

Methods and findings in experimental and clinical pharmacology

2009 | journal-article

The Role of Socioeconomic Conditions and Psychological Factors in the Willingness to Volunteer for Phase I Studies

Pharm Med

2008 | journal-article

Personality characteristics of volunteers in Phase 1 studies and likelihood of reporting adverse events.

2008 | journal-article

Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate.

2008 | journal-article

Abstracts from the ASENT 2008 Annual Meeting March 6–8, 2008

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2008 | journal-article

CA-125 AUC as a predictor for epithelial ovarian cancer relapse

Cancer biomarkers : section A of Disease markers

2008 | journal-article

CA-125 AUC as a predictor for epithelial ovarian cancer relapse

Cancer Biomarkers

2008 | journal-article

CA-125 AUC as a predictor for epithelial ovarian cancer relapse.

2008 | journal-article

Disposition of eslicarbazepine acetate in the mouse after oral administration

Fundamental & clinical pharmacology

2008 | journal-article

Dosage form proportionality and food effect of the final tablet formulation of eslicarbazepine acetate: randomized, open-label, crossover, single-centre study in healthy volunteers

Drugs in R&D

2008 | journal-article

Effect of food on the pharmacokinetic profile of trans-resveratrol

International journal of clinical pharmacology and therapeutics

2008 | journal-article

Effect of food on the pharmacokinetic profile of trans-resveratrol

International Journal of Clinical Pharmacology and Therapeutics

2008 | journal-article

Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

European journal of clinical pharmacology

2008 | journal-article

Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate

International journal of clinical pharmacology and therapeutics

2008 | journal-article

Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate

International Journal of Clinical Pharmacology and Therapeutics

2008 | journal-article

Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease

Clinical neuropharmacology

2008 | journal-article

Personality characteristics of volunteers in Phase 1 studies and likelihood of reporting adverse events

International journal of clinical pharmacology and therapeutics

2008 | journal-article

Personality characteristics of volunteers in phase 1 studies and likelihood of reporting adverse events

International Journal of Clinical Pharmacology and Therapeutics

2008 | journal-article

Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in healthy subjects

Drugs in R&D

2008 | journal-article

Pharmacokinetics, efficacy, and tolerability of eslicarbazepine acetate in children and adolescents with epilepsy

Journal of clinical pharmacology

2008 | journal-article

Stereoselective disposition of S- and R-licarbazepine in mice

Chirality

2008 | journal-article

The role of socioeconomic conditions and psychological factors in the willingness to volunteer for phase I studies

Pharmaceutical Medicine

2008 | journal-article

Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimize the oral bioavailability of vinpocetine

Journal of pharmaceutical sciences

2007 | journal-article

Effect of gender on the pharmacokinetics of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker

Biopharmaceutics and Drug Disposition

2007 | journal-article

Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma

Biomedical chromatography : BMC

2007 | journal-article

Performance of gentamicin population kinetic parameters in Portuguese neonates

Pharmacy world & science : PWS

2007 | journal-article

Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine, R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection

Analytica chimica acta

2007 | journal-article

The importance of permeability screening in drug discovery process: PAMPA, Caco-2 and rat everted gut assays

Current Topics in Pharmacology

2007 | journal-article

Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG monitoring

European journal of clinical pharmacology

2006 | journal-article

Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions

Clinical drug investigation

2005 | journal-article

CA 125 half-life breakpoint between a "good" and "poor" prognosis in patients with ovarian cancer

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2005 | journal-article

CA-125 AUC as a new prognostic factor for patients with ovarian cancer

Gynecologic oncology

2005 | journal-article

Effect of food on the pharmacokinetic profile of eslicarbazepine acetate (BIA 2-093)

Drugs in R&D

2005 | journal-article

Eslicarbazepine acetate (BIA 2-093) : relative bioavailability and bioequivalence of 50 mg/mL oral suspension and 200mg and 800mg tablet formulations

Drugs in R&D

2005 | journal-article

Lamotrigine pharmacokinetic/pharmacodynamic modelling in rats

Fundamental & clinical pharmacology

2005 | journal-article

Neuropharmacokinetic characterization of lamotrigine after its acute administration to rats

Methods and findings in experimental and clinical pharmacology

2005 | journal-article

Neuropharmacokinetic characterization of lamotrigine after its acute administration to rats

Methods and Findings in Experimental and Clinical Pharmacology

2005 | journal-article

Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects

Journal of clinical pharmacology

2005 | journal-article

Lamotrigine kidney distribution in male rats following a single intraperitoneal dose

Fundamental & clinical pharmacology

2004 | journal-article

Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/carbidopa

Clinical neuropharmacology

2004 | journal-article

Hydrophilic and hydrophobic cyclodextrins in a new sustained release oral formulation of nicardipine: in vitro evaluation and bioavailability studies in rabbits

Journal of controlled release : official journal of the Controlled Release Society

2003 | journal-article

Monitoring serum levels of gentamicin in neonates,Recém-nascidos e monitorização sérica de gentamicina

Acta Medica Portuguesa

2003 | journal-article

Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide

European journal of clinical pharmacology

2003 | journal-article

Relationship between plasma and brain levels and the anticonvulsant effect of lamotrigine in rats

European journal of pharmacology

2003 | journal-article

[Monitoring serum levels of gentamicin in neonates]

Acta medica portuguesa

2003 | journal-article

[Monitoring serum levels of gentamicin in neonates]

2003 | journal-article

Influence of administration vehicles and drug formulations on the pharmacokinetic profile of lamotrigine in rats

Fundamental & clinical pharmacology

2002 | journal-article

Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2002 | journal-article

Population pharmacokinetics of digoxin in pediatric patients

Therapeutic drug monitoring

2002 | journal-article

Lamotrigine analysis in blood and brain by high-performance liquid chromatography

Journal of chromatography. B, Biomedical sciences and applications

2001 | journal-article

Lamotrigine analysis in blood and brain by high-performance liquid chromatography

Journal of Chromatography B: Biomedical Sciences and Applications

2001 | journal-article

Population kinetics of tobramycin in neonates

Therapeutic drug monitoring

2001 | journal-article

PKBase: A population approach-oriented database [4]

Annals of Pharmacotherapy

2000 | journal-article

PKBase: a population approach-oriented database

The Annals of pharmacotherapy

2000 | journal-article

The kinetic profile of gentamicin in premature neonates

The Journal of pharmacy and pharmacology

2000 | journal-article

The kinetic profile of gentamicin in premature neonates

Journal of Pharmacy and Pharmacology

2000 | journal-article

Theophylline pharmacokinetics with concomitant steroid and gold therapy

Journal of clinical pharmacy and therapeutics

2000 | journal-article

Therapeutic monitoring of warfarin: The appropriate response marker

Journal of Pharmacy and Pharmacology

2000 | journal-article

Therapeutic monitoring of warfarin: the appropriate response marker

The Journal of pharmacy and pharmacology

2000 | journal-article

Predictive capacity of carbamazepine pharmacokinetic parameters in a Portuguese outpatient population

Therapeutic drug monitoring

1999 | journal-article

Kinetic profile of carbamazepine in an adult Portuguese outpatient population

Journal of clinical pharmacy and therapeutics

1998 | journal-article

The kinetic profile of vancomycin in neonates

The Journal of pharmacy and pharmacology

1998 | journal-article

The kinetic profile of vancomycin in neonates

Journal of Pharmacy and Pharmacology

1998 | journal-article

Carbamazepine population pharmacokinetics in children: mixed-effect models

Therapeutic drug monitoring

1997 | journal-article

Population pharmacokinetics of caffeine in premature neonates

European journal of clinical pharmacology

1997 | journal-article

Therapeutic monitoring of theophylline--a real need!

1992 | journal-article

Therapeutic monitoring of theophylline--a real need!

The Annals of pharmacotherapy

1992 | journal-article